ANZCTR search results

These search results are from the Australian New Zealand Clinical Trials Registry (ANZCTR).

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32707 results sorted by trial registration date.
  • Does a moderate dose fish oil intervention improve outcomes in older adults recovering from hip fracture?

    The anti-inflammatory properties of fish oil are well documented. Hip fracture is common and patients suffer significant unintentional weight and muscle loss leading to poor outcomes. An inflammatory response to the injury is a plausible mechanism for the lack of response observed in these patients when provided with best practice nutrition. This study aims to reduce the weight loss suffered by hip fracture patients by prescribing an intervention of individualised nutrition support and fish oil.

  • 2009 Cheese & Sterols Study. A 15 week randomised study investigating the effects of phytosterol-rich cheese products on cardiovascular markers on people with hypercholesterolaemia.

  • Observational study of an oral volume restriction device for slowing eating and achieving weight loss in overweight and obese individuals

    The purpose of this study is to explore the efficacy, acceptability and compliance associated with using the SMART device for weight loss in overweight and obese adults, and to gain experience with this device in Australia. Hypothesis: The use of the device will reduce oral food intake and lead to a substantial weight loss when combined with dietary advice and a physical activity program

  • Omega-3 oil and bone health

    Omega-3 oils are known to have benefits for joints, skin and the circulation. There are reasons to believe that they may help improve bone health in people with low bone density. This study aims to examine the safety, effectiveness and acceptability of an omega-3 oil, docosohexanoic acid (DHA) when given for 1 year in combination with calcium and vitamin D.

  • Evaluative Study of Quality of Life in pre-menopausal women with low-risk early breast cancer (Goserelin Study)

    This is a prospective study looking at treatment preferences, decision making, decision regret, patient preferences, side effects and disease outcome in pre-menopausal women under 47 years with low-risk early breast cancer. Recruitment is over 24-months at multiple sites in Australia and patients with "low risk" breast cancer will be invited to participate after they have chosen their treatment.

  • Randomised trial comparing controlled oxygen therapy with high-flow oxygen therapy in the treatment of patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) in the pre-hospital setting

    Purpose to determine if different oxygen therapies for patients having AECOPD in the pre-hospital setting have different outcomes (ie. Mortality, length of hospital stay, requirement for ventilation, difference ABGs)

  • Fremantle Primary Prevention study in general practice – a pilot study of risk factor modification for cardiovascular disease

    Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in 40+ year olds in Australia and much care is directed at dealing with the consequences of the disease at an advanced stage. Many of the risk factors (high cholesterol, high blood sugar, hypertension, obesity, inactivity, cigarette smoking) though modifiable are often undiagnosed and hence untreated. Even when diagnosed and when a treatment plan is in place, patient adherence to the treatment guidelines may not be as rigorously followed as expected. For many, the general practitioner (GP) is usually the point of first contact with the health system. GPs are well positioned to offer positive health messages and treatment options that can influence the health of their patients. This can be achieved through a combination of involving patients more in their own risk factor management and providing greater primary care support (GP and practice nurse) thereby stimulating the motivation for patients to increase their adherence to clinical guidelines. In light of this we undertook the “Fremantle Primary Prevention Study” over the last 18 months, in 1200 men and women aged 40-80 years recruited through 3 general practices in Perth. This study aims to show that while a significant proportion of the community are already known to have cardiovacular risk factors, GPs and their practice staff are ideally positioned to assess the extent of this potential morbibity and institute treatment modalities and exercise programs to reverse and modify them.

  • Improving Self Efficacy: Better outcomes for youth with depressive disorders.

    The purpose of this study is to test the feasibility of Self-Efficacy Focused Cognitive Behavioural Therapy (SEFCBT) for adolescents with depressive disorders and demonstrate that SEFCBT improves self-efficacy as well as depressive symptoms. It is hypothesized that study participants receiving SEFCBT will experience significant reductions in depressive symptoms.

  • A Single-Dose Safety and Tolerability Placebo Controlled Study of Subcutaneous SCH 900222 in Healthy Volunteers

    This study will evaluate the safety, tolerability, & pharmacokinetic response to SCH 900222 subcutaneous fixed dose in healthy subjects.

  • Bacterial adhesion to unworn and worn silicone hydrogel lenses

    To determine differences in the adhesion of various microorganisms on various silicone hydrogel lens materials and to determine whether lens wear modulates this adhesion.

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