ANZCTR search results

The purpose is to perform tonometry in HIV-infected adults before and after switching their HIV treatment from Kivexa to Truvada (or from Abacavir to Tenofovir). Hypothesis: that markers of cardiovascular function (as measured by applanation tonometry) will improve in patients switching from ABC-3TC to TDF-FTC.

Aim: A study investigating the bio-efficiency of de-alcoholised red and white wine as an antioxidant in humans using both red and white wine formulas. The study will be split into two 3 week blocks. Each participant will be involved for only 3 consecutive weeks. Recruitment: 8 healthy females are required. Study design: Participants will fast for 10 hours overnight (water allowed) prior to each study day. During the 24 hours prior to each visit, participants will be asked to refrain from consuming foods/drinks that are rich in polyphenolic compounds (a list will be provided to them). In the first week, participants will be randomised to one of 3 treatments. In the second week, participants will be randomised to one of the remaining 2 treatments and in the third week, participants will cross over to the last treatment. Drinks will be blinded to minimise any impact on the outcomes of the research.

The purpose of this study is to investigate whether the effect of selective serotonin reuptake inhibitors seen when used to treat anxiety are related to the drug, or to the fact that the people have an anxiety disorder. We expect that we will see "jitteriness" when healthy volunteers start taking the medication, and that the medication will reduce anxiety brought on by an experimental challenge in people who do not have an anxiety disorder.

Aim: To determine whether an online interactive intervention can improve physical activity and related behaviors in adolescents with cerebral palsy. Methods: Adolescents (11-17 year old) with cerebral palsy were recruited to this randomised controlled trial. Intervention participants used an 8-week online physical activity self-management program which incorporated education, self-reflection, goal setting and positive role modelling. Blinded assessments were undertaken at baseline, 10 weeks and 20 weeks. Outcomes included exercise knowledge, attitudes, intention and self-efficacy scales; self-reported physical and sedentary activity; objective physical activity; and functional capacity. Results: 41 adolescents (mean age 13y 7m: Standard Deviation 1y 8m; males n=26) participated. At the 10-week follow-up, the intervention group showed favourable changes (relative to the control group) approaching statistical significance for exercise knowledge (effect size 0.56, p=0.08) and physical activity behaviour as measured by pedometer (weekly step counts effect size 0.56, p=0.06; weekly moderate-to-vigorous physical activity effect size 0.50, p=0.06; weekly distance effect size 0.96, p=0.05). At the 20-week follow-up similar trends for change were observed but the effect sizes had weakened, suggesting a washout effect. Interpretation: Given the encouraging trends for change, interactive online programs may offer an effective alternative for participants unable to attend face-to-face programs.

We will examine the efficacy of an Internet based education program for improving the mental health of people with depression. Participants will be recruited via a website developed for this Program (www.climateclinic.tv), and a structured diagnostic interview via telephone. Consenting participants will be randomly allocated to an active Education Group, or Wait-List Control Group. Participants will complete six lessons of Cognitive Behaviour Therapy (CBT) based education delivered via the Internet and weekly emails from a clinician, weekly homework, and weekly contact with other participants via an online discussion board. Participants will be assessed at application, prestudy, one week poststudy, and 6 months poststudy. Once the Education Group have completed the lessons the Control Group will be given access to the lessons.

Before service provision models for the management of the complex array of disorders of movement, cognition and autonomic function associated with Parkinson can be comprehensively evaluated, there is a need for preliminary investigations to determine the best measurement tools to quantify therapy outcomes and program costs. Further data are also needed to map disease progression in a sample of people with Parksinon, providing a frame of reference against which inter-disciplinary therapy outcomes can later be evaluated. This study aims to address these needs as the first step in measuring the outcomes and costs of an inter-professional team model for the comprehensive management of people with Parkinson.

The current study aims to investigate the effectiveness of tyrosine (an amino acid found naturally in protein foods) in the treatment of adolescent females with anorexia nervosa. The design of the study is a double-blind randomized control trial (RCT). The design will allow for the investigation of the effects of tyrosine in the study population, the testing of process measures, and exploration of recruitment and loss to follow up in clinical trials in people with anorexia nervosa.

The pain of birthing may be the most severe type of pain a woman will experience in her lifetime. Analgesia in childbirth remains controversial and includes the use of non-pharmacological and pharmacological measures including parenteral (intravenous, intramuscular) opioids (pethidine) and epidural analgesic agents (fentanyl). Intranasal fentanyl is an alternative, non-invasive route of opioid administration and has been shown to be effective in relieving both acute & chronic pain. Patient controlled analgesia has also been shown to effective and safe for women in labour and for post-operative analgesia administration. The primary aim of this study is to assess the safety and efficacy of patient-controlled intranasal fentanyl (PCIF) for analgesia in birthing women. Our secondary objective is to examine patient satisfaction of PCIF within 48 hours of birth. This will be an uncontrolled non-comparative clinical trial. Participants will self-administer intranasal fentanyl for pain during childbirth. Participants will include 50 consenting adult women who present to Sunshine Hospital for childbirth and are being managed within the Caseload Model of Care. Data will be analysed used descriptive statistics.

The study is looking at efficacy of combination of oral vinorelbine and cisplatin with radiation for locally advanced lung cancer. The combination is unique as it combine oral with intravenous treatment.

The primary purpose is to determine the effect of E7080 on the objective response rate (ORR) based on Response Evaluation Criteria in Solid Tumors (RECIST) by independent imaging review (IIR) and determine the pharmacokinetic (PK) profile and pharmacokinetic/ pharmacodynamic (PK/PD) relationships in the patients with medullary thyroid cancer [MTC] or radioiodine (131I) refractory/resistant differentiated thyroid cancer[DTC].