ANZCTR search results

The primary purpose of this study is to investigate the hypothesis that a multifactorial, multidisciplinary falls prevention programme can prevent falls in an acute hospital setting.

The study aims to evaluate the diagnostic accuracy of a new cellular imaging device for identifying endometriosis lesions during surgery which require treatment or removal.

Overall, there were two key aims of the current study. First, to assess the effectiveness of perfectionism and media literacy programs compared to control classes, in attempting to reduce eating disorder risk factors. Outcomes were examined with the targeted variables (perfectionism, media internalization and perceived pressure to be thin) as well as other eating disorder risk factors (e.g., shape and weight concern, dietary restraint, depression, self-esteem etc). Second, to qualitatively assess students’ perceived value and enjoyment of the respective programs. This was the first time an eating disorder prevention program targeting perfectionism had been evaluated.

This study will evaluate the safety (i.e. incidence and type of adverse events) and efficacy (i.e. change from baseline in the 4 symptom nasal score for the entire double-blind treatment period) of CMP administered three times daily intranasally over a four week period to people with seasonal allergic rhinitis (SAR) as compared to placebo.

The aim of this clinical study is to determine how well a new prolonged release oxycodone/naloxone combination tablet works in reducing constipation whilst still giving the patient the required amount of pain relief in patients suffering from cancer pain.

The primary purpose of this study is to determine whether PES is an effective treatment choice for people with osteoarthritis of the knee. The hypothesis is that PES will produce a clinically important and sustained improvement in pain, function, patient global assessment, quality of life and physical activity when compared with placebo treatment in individuals with osteoarthritis of the knee.

The primary purpose of the study is to investigate the effects of vibration platform training on bone health in postmenopausal women. The primary hypothesis is that vibration training will be associated with an increase in blood borne markers of bone metabolism after 8 weeks.

There is no update to the original ethics submission

The purpose of the study is to determine whether the act of measuring and providing feedback on adherence will result in a change in adherence with preventive medication and as a secondary outcome disease control. Subjects who are aware that their use of medication is being monitored may change their behaviour. Providing feedback may provide them and thier physician with additional information which may improve the accuracy and quality of clinical decisions that are made.

Polysomnography (PSG) is a clinical test that is used to diagnose breathing disorders that occur during sleep. The most common of this type of disorder is Obstructive Sleep Apnoea (OSA). People with OSA experience periods of partial or complete obstruction of the throat during sleep. It is a serious disorder when severe, with good treatments available. Accurate diagnostic tests are therefore very important. The main outcome measures from the PSG test are the number of obstructions per hour of sleep, the number of arousals from sleep and the amount and quality of sleep. Scoring these features from PSG recordings relies heavily on visual pattern recognition by trained observers applying pre-defined rules. The recognition of features and application of the rules is therefore subject to interpretation by individual scorers and this has the potential to affect measurement reliability. Inter-scorer variations in PSG outcome measures may affect the accuracy of clinical evaluation of individual patients and also decrease statistical power in research studies, particularly multicentre research studies. Several studies have examined the reliability of scoring PSGs. All have demonstrated significant variability in scoring of PSGs and there is therefore a strong incentive to investigate sources of inter-scorer variability and to develop methods aimed at achieving improvements. Our group has recently developed methods that allow measurement of PSG scoring reliability to be assessed and potentially improved through external proficiency testing (EPT). They rely on distributing test PSGs to participating laboratories and determining the consistency of scoring using a purpose-written computer application. However, there are no studies that evaluate whether applying the principles of EPT to PSG scoring is effective in improving scoring consistency. If EPT proves to be ineffective, then it is likely that an active process that aims to align scorer technique will be necessary. The purposes of this study are therefore to: 1. Evaluate whether a program of EPT improves scorer consistency 2. Evaluate whether an active process for identifying and correcting causes of discordance (alignment process) in addition to EPT further improves scorer consistency The demonstration of effective methods for improving scorer consistency will have important benefits for both patient care and research.