ANZCTR search results

The primary objective of the project is to determine the benefit of using multiple physical modalities for treating and preventing contracture in adults with traumatic brain injury. An assessor blinded, multi-centre, randomised controlled study will be conducted. In this study, the ankle is selected as a model to asess if a multi-modality programme (tilt table standing combined with ankle splinting and electrical stimulation) is more effective than usual care (tilt table standing alone). The participants are people with traumatic brain injury admitted to the brain injury rehabilitation units of the Royal Rehabilitation Centre Sydney, Liverpool Hospital and Westmead Hospital.

The process of laparoscopy can result in shoulder pain post-operatively, apart from what is performed surgically. This pain is thought to be from the gas used to inflate the abdomen. We propose to test a manoeuvre, recently reported to be successful for reducing this pain in another patient group, in our obesity surgery patients. The manoeuvre is a series of five manual "breaths" near the end of surgery which may help to expel the inflating gas from the abdomen, and leave less of the gas to irritate the abdominal lining post operatively, which is felt as shoulder pain.

The purpose of this research is to investigate the use of electrical stimulation to support a muscle strengthening program aimed at increasing standing function in individuals with incomplete spinal cord injury (SCI). Specifically, this project will establish whether there are any differences in outcome using a conventional stimulation pattern (low frequency) or a new, higher frequency stimulation pattern. The project will test the hypotheses that, following training using a combined FES-voluntary muscle strengthening program, motor-incomplete SCI individuals will be able: 1. to stand for longer; 2. to perform significantly more repetitions of the sit-to-stand/stand-to-sit activity ; 3. to achieve significantly greater upper limb reach.

This study is an observational study looking at women who cannot contract their pelvic floor muscles. This study applies to all women who have had a pregnancy and includes those delivered by caesarean section.

The primary aim of this randomised controlled trial is to determine whether giving antenatal dexamethasone to women at risk of preterm birth at less than 34 weeks gestation increases the chance of their children surviving free of neurosensory disability at 2 years’ corrected age, compared with women given antenatal betamethasone. The primary hypothesis of the study is that, compared with betamethasone, antenatal dexamethasone given to women at risk of preterm birth (less than 34 weeks gestation) reduces the risk of death or any neurosensory disability, caused by impairments such as cerebral palsy, blindness, deafness or developmental delay, in their children at 2 years’ corrected age. Specific aims are to assess whether dexamethasone has greater short-term benefits than betamethasone (a greater reduction in the risk of intraventricular haemorrhage as suggested by a new systematic review) and whether there are longer-term effects on childhood neurological function, including motor function, cognition and behaviour, as well as body size, blood pressure and general health.

This is a randomised, double-blind placebo controlled trial in the use of Chinese herbal medicine in the management of primary dysmenorrhea in Australia. This investigation seeks to establish whether Chinese herbs offer any beneficial effect in the management of this disorder. Dysmenorrhea is a common gynaecological complaint among adolescent girls and women of reproductive age and refers to the occurrence of painful menstrual cramps of lower abdominal origin. This trial will include the assessment of Chinese herbs in standard and individual formulas against placebo.

Delayed Onset Muscle Soreness (DOMS) and muscle damage are common and expected self-limiting sports training related conditions that can result in a loss of muscle force and significant pain. For athletes required to train and compete in close succession, DOMS can pose an obstacle to optimal performance. At present there are multiple methods for treating DOMS. Methods include; cryotherapy, anti-inflammatory medications, stretching, hypo-baric oxygen therapy, homeopathy, ultrasound, E-stimulation, L-carnitine, rest and light exercise. To date, a sound and consistent treatment for DOMS has not been established. High-quality scientific research into Complementary and Alternative Medicines (CAM) and DOMS is limited despite the increase usage of such products by athletes. This is a randomised, double blind, placebo controlled trial that looks at four selected CAM’s in four sub-studies and their effect on DOMS and muscle damage in sub-elite athletes.

Sleep disorders are a significant public health issue in Australia. The direct ‘health care’ costs of sleep disorders account for only 2% of their estimated economic impact ($10.3 billion) which suggests that there may be too little investment in the prevention and treatment of sleep disorders. In a first of its kind, this project proposes to conduct a screening and awareness program to be run through community pharmacies by specially trained pharmacists. Further, the project aims to conduct a randomised controlled trial to evaluate the effectiveness of two sleep health models in the community pharmacy setting; a basic online screening tool for identification of sleep disorders versus a more comprehensive sleep screening and sleep health program for the diagnosis and reduction of patient risk factor profile for developing sleep disorders. Through the participation of pharmacists, patients with sleep disorders will have improved access to information about the diagnosis, treatment and management of their conditions, especially in rural settings. The increased awareness and education about sleep health amongst pharmacists and the general public will allow for improved identification of sleep disorders and disease management, and lead to cost savings for patients, providers and the health care system. Given previous success of pharmacy based screening and intervention programs by the research team, the project has a high likelihood of success, and will deliver very valuable outcomes. This will be the first project to test the effectiveness of community pharmacies as an alternative health care site for the improvement of sleep health outcomes in Australia, and one of the first globally.

This Phase Ib/II, open-label, multicenter trial is designed to evaluate the safety, pharmacokinetics, and efficacy of Apo2L/TRAIL when combined with rituximab in subjects with follicular, CD20+, B-cell NHL that has progressed following a response of = 6 months duration to a prior rituximab-containing therapy. The multicenter, international, randomized Phase II part of this study will commence only after the safety and available pharmacokinetic data from the Phase Ib part of the study have been evaluated by the Sponsor and have been provided to participating investigators and the FDA.

The objective of this pilot trial is to assess the safety of antibiotic drop instillation compared to a control group using saline drops instead of antibiotic during continuous lens wear.