ANZCTR search results

Safe and effective regional anaesthesia requires local anaesthetics to be placed in close proximity to nerves without injury to the target nerves or adjacent structures. A promising approach to the provision of postoperative analgesia after abdominal surgery is to block the sensory nerve supply to the anterior abdominal wall. Ultrasound guidance allows accurate identification of target tissue planes whilst avoiding adjacent structures. Ultrasound guidance also allows spread of local anaesthetic to be monitored in real time during the injection. We therefore anticipate improved safety and efficacy when utilising ultrasound guided TAP block when compared to standard care. Standard care for laparascopic appendicectomy involves general anaesthesia and endotracheal intubation, intravenous opiate and local anaesthetic infiltration of laparascopic port sites by the surgeon. In this study we will add to standard care bilateral ultrasound guided TAP block.

This project aims to assist culturally and linguistically diverse consumers safely manage their complex medication regimens for the co-existing comorbidities of cardiovascular disease (CVD), diabetes and chronic kidney disease (CKD). Taking medicines as prescribed is critical for well-managed chronic diseases. Approximately 40% of Victorians with CVD, diabetes and CKD speak a language other than English at home, most commonly Greek, Italian, and Vietnamese, which increases the likelihood of medicine-related problems. A language-specific medication intervention to enhance medication self-efficacy will be developed and tested. Better medicine self-efficacy results in improved general wellbeing, medication safety and reduced healthcare costs. Null hypothesis: 1. Compared to patients receiving standard care, patients who receive the intervention will show no change in medication self-efficacy

AIMS: The primary aim of this project is to determine if a simple intervention (a personalised postcard, sent monthly) improves psychosocial outcomes in patients with a recent stroke. The secondary aim is to determine appropriate outcome measures and potential mechanisms of action for a large, multi-centre, randomized controlled trial in patients surviving stroke. RESEARCH PLAN: This is a single-centre (Gosford Hospital Stroke Service), randomized, double-blind pilot/proof of concept trial of a simple intervention to improve psychosocial outcomes in patients with a recent (within 8 weeks) stroke.

The aim was to study whether indigo carmine dye spray colonoscopy increases a detection rate of colorectal polyp including flat adenoma in an Australian population.

The primary purpose of the study is to determine the effectiveness of dynamic splints applied for two months on wrist stiffness and patient restrictions following wrist fractures.

The aim of the project is to test whether giving a medication called desferrioxamine (commonly used in patients with iron-overload conditions such as beta-thalassaemia) in the setting of a heart attack can reduce the amount of heart muscle injury. We hypothesise that that this medication may therefore improve the outlook for people following heart attacks. This medication has been used safely in adults and children with beta thalassaemia at even higher doses. This drug has been shown in experimental, animal and a few human studies to reduce the “oxidative stress” (that is, acts as an “antioxidant”) of tissues which have had their blood supply compromised (as in the case of a heart attack). Some of the animal studies have also shown that it reduces the size of heart attacks.

Prospective, randomised, 28-week trial in 40 patients. The first step: forty (40) eligible, consented participants will switch from existing PI or NNRTI and commence ritonavir-boosted lopinavir at week 0 (2 tablets twice-daily). The second step: patients on lopinavir/r will be randomised to initiate study therapy at week 4 (4 weeks after initiation of lopinavir/r) for 24 weeks. Eligible subjects will be randomised equally (10 patients per group) to: 1. uridine (36g tid for 10 days per month) 2. pravastatin (40 mg nocte) 3. uridine (36g tid for 10 days per month) + pravastatin (40 mg nocte) 4. delayed treatment arm (DTA) All patients will be offered the combination of pravastatin and uridine for 24 weeks from week 28.

Beneficial effects of moderate- to high- injtensity resistance exercise have been reported in Type 2 diabetes but there is little information available regarding the effects of resistance exercise in Type 1 diabetes. Therefore the purpose of this study is to examine the effects of an acute bout of moderate- to high- intensity resistance exercise on 48-hour blood glucose profiles in Type 1 diabetes using continuous glucose monitoring.

This project will develop a simple questionnaire to allow health care professionals to identify features contributing to poor asthma control, in patients who are currently using inhaled corticosteroid/long-acting b2-agonist combination inhaler.

We aim to trial dexmedetomidine as a sedating agent for awake diagnostic fibreoptic bronchoscopy. It has a number of unique properties which we feel would be useful - sedating, reduces discomfort and stress during potentially uncomfortable procedures. We would be monitoring for any problems or adverse events during this trial.