ANZCTR search results

To evaluate the on-eye performance of marketed contact lenses and contact lens solutions so as to evaluate which combinations perform best with each other

The aim of the study is to examine the effect of dairy consumption on satiety and certain aspects of cognition in a sample of primary school children aged 10-12 years. It is hypothesized that beverages with a lower glycaemic load and higher dairy composition will be associated with improvements in measures of cognitive function and satiety compared to beverages high in gylcaemic load and containing no dairy food.

The objective of the proposed research is to establish a clinical program to test novel therapeutic interventions for TBI patients with fatigue and/or sleep disturbance. Specifically, the proposed four-year study aims to evaluate, in a randomized controlled trial, the effectiveness of light therapy, administered for 4 weeks in alleviating fatigue, sleep complaints, and cognitive performance following TBI. Our primary hypotheses are that participants receiving blue light therapy daily (active condition) will show reduced self-reported fatigue, reduced daytime sleepiness, improved sleep (assessed subjectively and objectively) and improved cognitive performance 4 weeks after commencement of therapy compared to those receiving the yellow light condition (placebo) and treatment as usual condition.

This study is being undertaken as a masters degree thesis. There is alot of anecdotal evidence of chiropractic care helping children with learning disabilities. The purpose of this research is to use a scientific method to measure if children having difficulty reading can benefit from chiropactic care.

Painful HIV-SN is a neurological complication of HIV infection that can result from either the HIV disease process itself and/or from the use of some of the anti-retroviral medications that are used to treat HIV. There has been considerable research into the treatment of painful HIV-SN neuropathy. However, treatment with currently available pain killing medications rarely renders the patient pain free and the use of medications may be limited by side effects. This current research project is only being offered to the participants who have taken part in the previous research project entitled “A placebo controlled multiple dose research project of Flupirtine for the treatment of painful HIV-SN”. The previous study has the protocol number CNSBio 01/07. “CNSBio 01/07” is investigating the short-term (one week) effectiveness and safety of the pain killing medication Flupirtine when taken in combination with opioids for the treatment of painful HIV-SN. CNSBio 01/07 is not yet completed and the results of this clinical trial are not yet available. The purpose of this research project is to investigate further if the drug Flupirtine is a safe and effective treatment for HIV-SN when taken in combination with opioids for longer than a week (up to one year). Flupirtine is an experimental treatment. This means that currently the drug is not an approved treatment for painful HIV-SN in the United States by the Food and Drug Administration (FDA) or in Australia by the Therapeutic Goods Administration (TGA). It is however approved for the treatment of back pain, muscle stiffness and pain associated with surgery and arthritis in Germany, Russia, Portugal, China and Brazil. CNSBio Pty Ltd is sponsoring the current research project with the aim of developing Flupirtine for the treatment of painful HIV-SN in Australia and America if flupirtine proves to be safe and effective in this context.

The efficacy of Temazepam on sleep disordered breathing in untreated patients with mild to moderate OSA as measured by the Apnea Hypopnea Index (AHI) via standard overnight polysomnography (PSG). The effect of temazepam on OSA will be correlated with awake HVR and HCVR. The hypothesis is that Temazepam reduction of OSA will be correlated with the baseline HVR and HCVR.

This study aims to determine if early intervention for chronic pain problems, provided in the form of physiotherapy triage, improves patient outcomes while they wait for their physiotherapy treatment. Triage involves a brief assessment, with advice about pain management, basic exercises and resource information.

HIV associated painful sensory neuropathy (HIV-SN) is a common and disabling neurological complication of HIV infection, that may result from damage to sensory nerves from either HIV disease itself and/or as a side effect some of the medications used to treat the HIV infection. The damaged sensory nerves develop increased activity and transmit excessive pain signals, even when no pain stimuli are present. Pain in the feet is the most frequent symptom, as well as burning and painful soles and/or numbness usually occurring bilaterally in the extremities. There has been considerable research into the treatment of painful HIV-SN, but current therapies typically afford inadequate relief of symptoms and may have unpleasant side effects. Flupirtine is an orally available, centrally acting non-opioid analgesic that has been used in Germany for the treatment of acute pain, back pain and muscle stiffness since 1984. The purpose of this study is to investigate if the pain relieving drug flupirtine is a safe and effective treatment for painful HIV-SN when used together with opioid medication.