ANZCTR search results

The primary aim of this 18-month randomised, double-blind, placebo-controlled clinical trial is to establish whether vitamin D supplementation can delay progression of cognitive decline amongst older adults with Mild Cognitive Impairment (MCI) who have low vitamin D concentrations (between 12.5 and 50 nmol/L). The main hypothesis of this study is that older adults with MCI randomised to a 18-month treatment with vitamin D will experience significantly less cognitive decline (as measured with the CAMCOG) at the end of the 18-months follow-up than subjects with MCI randomised to placebo. Secondary outcomes of interest for this study include quality of life, gait, balance and muscle strength.

Main purpose of this study is to identify whether a single injection of Avastin, in addition to the current antiscarring treatment 5 FU, improves the outcome from trabeculectomy surgery.

The purpose of the study is to find out whether the addition of an attention re-training component to our best-practice treatment program can provide a significantly greater treatment effect, and enhance the maintenance of effects. This will inform the development of future programs to help people suffering from social phobia.

This study looks at the disclosure of information indicating a genetic risk of cancer. Who is it for? You can join this study if you attend a Victorian Familial Cancer Centre and you are the first person in your family to have a genetic (mutation) test for breast, ovarian or colorectal cancer and your test is positive (that is, you have a gene that predisposes you to cancer). Trial details Participants will be randomly divided into two groups. Participants in one group (the treatment group) will be encouraged to tell their relatives about the result of their genetic test, and a Risk Notification Letter will also be sent to their relatives from the Familial Cancer Centre. This process is called ‘active disclosure’. Participants in the other group (the control group) will be encouraged to tell their relatives the result of their genetic test, but a letter will not be sent from the Familial Cancer Centre. This process is called ‘passive disclosure’. The number of relatives from both groups who contact the Familial Cancer Centre during the next year will be recorded. The number of relatives who have genetic tests and the acceptability of the process to participants and their relatives will also be measured. The aim of the study is to test whether active disclosure may be a more effective and acceptable way of providing information to people who may have a genetic predisposition to cancer.

Macular oedema, or swelling around the macula, results in decreased vision. It is termed "refractory" when it does not adequately respond to the usual treatment methods. It can occur with conditions like diabetic retinopathy or uveitis. Without effective treatment, vision loss can progress and become permanent. Early studies have suggested that a new treatment called Avastin (Bevacizumab) may be effective in treating this type of macular oedema, however further research is required to confirm this. Choroidal neovascularisation (CNV) is a condition where abnormal blood vessels grow in the back of the eye and causes blurred or distorted vision. Without treatment, vision loss may be quick and severe. There are many causes of CNV, the most common being Age Related Macular Degeneration. Uveitis can also cause this condition. As Avastin (Bevacizumab) has been found to be useful in the treatment of CNV due to AMD, it is expected that it will be useful in cases of CNV from uveitis. The purpose of this project is to assess whether Avastin (Bevacizumab) is both safe and effective in the treatment of the above conditions, namely: 1. Macular oedema due to diabetic retinopathy 2. Macular oedema due to uveitis 3. Choroidal neovascularisation due to uveitis

This RCT is designed to test weather the CLIMATE Schools Alcohol and Cannabis program is more successful in preventing Alcohol and cannabis use and related harms, compared to the current programs

Intubation is the insertion of an endotracheal tube into the trachea of an anaesthetized patient for airway management during surgery. Intubation is traditionally achieved by inserting a laryngoscope into the anaesthetized patient’s mouth, moving the tongue out of the way and inserting the endotracheal tube through the vocal cords if they can be seen. In the last decade there has been growing interest in a new type of intubating device called optical stylet. Optical stylets incorporate fiberoptic imaging elements in an intubation stylet design. Their appearance is of a thin semi-rigid telescope which an endotracheal tube is threaded over. While any patient may be intubated using a stylet, they have been particularly reccomended for difficult intubations, which occur with an incidence of between 1:300 and 1:3000 (rising with conditions such as obesity and sleep apnoea). The proposed study compares the ease of use and intubation success of the 2 optical stylets, the Bonfils (Storz, Germany) and the Levitan (Clarus, USA) (pictures) amongst specialist anaesthetists whose only experience with them was basic training with the device on airway mannikins. Both devices will be used according to their approved application for device entry at the Therapeutic Goods Administration.

Spinal Cord Injury (SCI) is a sudden and traumatic event causing permanent paralysis and ongoing disability. Respiratory dysfunction is a major cause of morbidity and mortality in SCI, causing reduced lung volumes and air flow rates. Some people living with quadriplegia (the loss of function in both arms and legs) are able to sing far more effectively than would be predicted on the basis of their injury level and severity alone. This study aims to determine the mechanisms by which these individuals achieve such impressive functional outcomes. Ten chronic cervical SCI subjects and 10 matched controls will be assessed during singing and speech using standardised phrases. Physiological tests including spirometry and EMG analysis will be utilised in addition to acoustic analysis of vocal amplitude. It is expected that in order to achieve the increased respiratory support required when singing, patients with quadriplegia will use innovative muscle recruitment and control strategies. The results of this investigation have important implications for therapeutic singing interventions during rehabilitation. Given that respiratory dysfunction is a major cause of morbidity and mortality after SCI, the effect of singing on respiratory function warrants further, rigorous investigation.

Random assignment to either Nissen or anterior 90 degree partial fundoplication. Outcome is reflux control and side effects (especially dysphagia)

Random assignment to either Nissen or anterior partial fundoplication. Outcome is relfux control and side effects (especially dysphagia)