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Limited Institution Study for Treatment of Acute Lymphoblastic Leukamia for Paediatric Patients in Australia,New Zealand and The Netherlands
Expand descriptionMost children with leukaemia are cured, but those with the worst forms do less well. This trial is testing new ways of combining the most effective drugs, and adding a tranplant for children with the worst forms of leukaemia and a suitable donor. This tiral will determine if these new approaches could improve cure rates, and if they could be used more widely.
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The effects of nebulised N-acetylcysteine on sputum quality and diagnostic yield: a randomised, controlled clinical trial
Expand descriptionWe believe that the use of N-acetylcysteine (a known mucolytic) will be useful in improving the diagnostic yield of sputum culture. If this hypothesis is proven, this agent can be recommend for this purpose.
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Multicentre randomised trial of Anterior 90 degree vs Nissen fundoplication for the treatment of patients with gastro-oesophageal reflux
Expand descriptionRandom assignment to either Nissen or anterior 90 degree partial fundoplication. Outcome is reflux control and side effects (especially dysphagia). Trial conducted in 6 cities in Australia and New Zealand
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A multi centre, open label study to evaluate efficacy and safety of 1000 mg of rituximab on day 1 and 15 in patients with idiopathic thrombocytopenic purpura
Expand descriptionReview efficacy of giving rituximab on day 1 and 15 to see if platelet levels recover and how long a response last. Patients will attend regular visits for the collection of blood samples
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“Accelerated BEP” A feasibility study of accelerated BEP as first line chemotherapy for advanced germ cell tumours
Expand descriptionThis is a study on the safety and effectiveness of accelerated treatment with three chemotherapy drugs (bleomycin, etoposide and cisplatin with pegylated G-CSF) known as ‘accelerated BEP’, in treating people with advanced germ cell tumours. Who is it for? You can join this study if you have germ cell cancer that has spread to distant sites and is widespread. Trial details All participants will receive accelerated BEP chemotherapy intravenously over two week cycles. The number of cycles will be determined by the person’s risk of disease and their response to treatment. Accelerated BEP is a more intense treatment than the standard treatment, and may cause more side effects. This clinical trial will investigate the safety and efficacy of the new regimen as well as its impact on lung function, and neurotoxicity as rated by the participants.
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Randomised trial of Ablation vs no Ablation of Barrett's oesophagus with Argon Plasma Coagulation in patients who have not undergone surgery for reflux
Expand descriptionComparison of Argon plasma Coagulation with surveillance for the reversal of Barrett's oesophagus and the prevention of cancer in the oesophagus, in patients who are taking conventional medications for gastroesophageal reflux
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Randomised trial on the efficacy of Ablation vs no Ablation of Barrett's oesophagus with Argon Plasma Coagulation following laparoscopic fundoplication for the reversal of Barrett's oesophagus
Expand descriptionComparison of Argon plasma Coagulation with surveillance for the reversal of Barrett's oesophagus and the prevention of cancer in the oesophagus
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Can singing training can improve voice projection for people with a spinal cord injury?
Expand descriptionRespiratory dysfunction is a major cause of morbidity and mortality in spinal cord injury (SCI). Therapeutic singing exercises have been demonstrated to develop muscle control, expand lung capacity and increase vocal intensity with other clinical populations. This study will be the first to systematically document the physiological effect of singing instruction on respiratory function and voice projection in a quadriplegia population. All subjects will participate in physiological and acoustic assessments whilst vocalising, singing, and speaking. Forty subjects with chronic cervical SCI will be randomised into control and experimental groups. Subjects in the treatment group will participate in twice weekly singing instruction in small groups (n=5), with an additional weekly homepractise session, for a period of 20 weeks. All subjects will repeat the initial assessments after 10 and 20 weeks. Control subjects will participate in the vocal training after 20 weeks. The relevance of this project is indicated by research that shows that respiratory disorders and subsequent diminished vocal projection are common and disabling in the quadriplegia population. Singing training has been shown to improve respiratory capacity and voice projection in other clinical populations. In a health care setting where evidence-based practise is highly valued, the examination of the effect of this innovative therapy on ventilatory function is strongly indicated.
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The effect of a high intensity functional exercise program on physical performance in older adults at discharge from in-patient rehabilitation – A feasibility study
Expand descriptionThe aim of this project is to look at how feasible it is to (1) conduct a functional exercise program in addition to a usual rehabilitation program, and (2) to explore how effective an outcome measure (Physical Performance Test) is at measuring the physical function of people being admitted and discharged from an in-patient rehabilitation program.
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Randomised controlled trial of the effect of mandibular advancement splint (MAS) versus positive airway pressure (PAP) therapy on blood pressure in obstructive sleep apnoea
Expand descriptionThe broad aim of the project is to compare MAS and CPAP treatment in patients with Obstructive Sleep Apnoea to test the hypothesis that these treatments have equivalent health effects in terms of important clinical outcomes as a result of the superior efficacy of CPAP being offset by lower treatment compliance than MAS.