ANZCTR search results

To investigate a commonly used anti-nausea drug, tropisetron, and its application to preventing post-cardiopulmonary bypass delirium.

Too see if perhexilin can decrease the symptoms of chest pain and breathlessness in people who have severe aortic stenosis.

To see by what means or mechanism ACE inhibitors reduce the chance of heart attack or stoke

The replacement of dietary carbohydrate with protein, combined with a low intake of fat, has been shown to induce larger weight loss in overweight participants when compared with conventional high carbohydrate/low fat diets and is an increasingly popular method for weight loss among the general public, suggesting this is a favourable weight loss regime for overweight people. There are concerns over the safety of the use of high protein-red meat diets, as red meat, although controversial, is proposed to increase the risk of colon cancer. Although a high protein-red meat diet may be associated with increasing the risk of colon cancer due to the higher content of meat, such a diet is also associated with weight loss and improved insulin sensitivity, which reduce colon cancer risk. From this it can be suggested that a higher protein dietary pattern used for weight loss that remains low in fat and high in fibre rich foods, in association with moderate exercise may not increase the risk of colon cancer. The impact of long term use of high protein-red meat diets on colon cancer risk has not been assessed. This study will assess the safety of high protein-red meat diets as a method for weight loss in overweight participants. It will also investigate a series of secondary outcomes that impact on total health status.

Radiolabelled antibody treatment of Hodgkin's disease and other lymphomas which have either not responded to conventional chemotherapy and/or radiotherapy, or which have relapsed following initial response to standard treatment.

The COSAQ trial aims to establish the impact on sleep function of using a CPAP nasal mask and pump at night. Continuous positive airway pressure (CPAP) is a nasal/facial mask and machine used at night to treat sleep apnoea. Although CPAP is the usual treatment for sleep apnoea, previous reports suggest that is poorly tolerated in acute quadriplegia. A maximum of 35% of those with chronic quadriplegia are adherent with therapy, with a higher rate of 50% in acute quadriplegia. A range of factors including severe immobility and psychological factors appear to contribute to a low acceptance of CPAP. The SHiQ COSAQ project will examine the impact on sleep function, quality of life and cognition of using CPAP, and establish whether the benefit of using CPAP is outweighed by the inconvenience of using it. People with quadriplegia have extremely high rates of sleep apnoea after injury which is undoubtedly limiting their rehabilitation. Successful treatment may improve acute, sub-acute and community outcomes for this group and demonstrate significant cost-utility.

Rational for project Many studies have investigated the treatment of post operative nausea and vomiting (PONV) However, there is disagreement on both the incidence of PONV and how to prevent it Few studies have investigated the period post discharge Day case gynaecological surgery patients are particularly at risk of PONV There is evidence that total intravenous anaethesia may decrease the incidence of PONV This study sets out to investigate a specific subgroup of high risk patients. This will allow for specific recommendations to be made regarding the management of this subgroup of patients.