ANZCTR search results

The primary purpose of the study is to test whether a supplement containing a specific component of cocoa (called flavanol) will decrease blood pressure, improve the function of the lining of blood vessels and increase sensitivity to insulin if consumed for 24 weeks.

This is a TROG multicentre feasibility study of APBI using 3D CRT in selected women with node-negative breast cancer treated by breast conserving surgery with negative margins. This is a one-arm feasibility study in which the primary endpoint is the feasibility rate for APBI using 3D CRT. This is defined as the proportion of eligible patients treated without a major protocol deviation. Secondary endpoints include radiation toxicity, cosmetic outcome, quality of life, time to ipsilateral breast recurrence, disease-free survival and overall survival. Primary objectives: To evaluate the technical feasibility and reproducibility of APBI limited to the region of the tumour bed using 3D CRT following breast conserving surgery. Secondary objectives: - To assess the acute and long term toxicity of APBI using 3D CRT. - To examine the cosmetic outcome of women with breast cancer treated by breast conserving surgery and APBI using 3D CRT. - To determine the time to ipsilateral breast recurrence, disease free survival and overall survival of women with node-negative breast cancer completely resected by breast conserving surgery followed by APBI using 3D CRT. - To assess the quality of life of women with node-negative breast cancer treated by breast conserving surgery and APBI using 3D CRT

This trial is designed primarily to determine whether maximal androgen deprivation, prior to and during radiation therapy, reduces the rate of local failure and appearance of metastases that takes place after radiation therapy. A secondary aim is to determine whether a short period of androgen deprivation (3 months) is as effective as a longer period (6 months). A tertiary aim to see whether the tumour shrinkage caused by androgen deprivation prior to radiation therapy leads to any noticeable reduction in the long-term side-effects of subsequent radiation therapy. By defining the tolerability of and compliance with the regimens used, the final objective is to determine whether androgen deprivation as produced in this study is applicable for widespread use outside of the randomised clinical trial setting.

This study examines the effect of a high energy intake on inflammation in asthma. We hypothesise that a high energy diet will cause an increase in both systemic and airway inflammation. Subjects are randomly assigned to a high energy or low energy diet for 24 hours. Systemic and airway inflammation will be assessed at 0, 4 and 24 hours.

We will examine the efficacy of an Internet based education program for improving the mental health of people with social phobia. Participants will be recruited via a website developed for this Program (www.shyness.tv), and a structured diagnostic interview via telephone. Consenting participants will be randomly allocated to an active Education Group, or Wait-List Control Group. Participants will complete six lessons of CBT based education delivered via the Internet and weekly emails from a clinician, weekly homework, and weekly contact with other participants via an online discussion board. Participants will be assessed at application, prestudy, one week poststudy, and 6 months poststudy. Once the Education Group have completed the lessons the Control Group will be given access to the lessons.

ProsCan will follow men with prostate cancer from the time of diagnosis to five years post-treatment to better understand their patterns of care and the resulting impact of diagnosis and treatment on their psychosocial, physical functioning and quality of life outcomes. In addition, the genetic biomarkers of prostate cancer will be investigated with particular emphasis on the relationship between biomarkers and clinical/medical outcomes. The project will evaluate whether there are subgroups of men who have better or worse outcomes based on the analysis of psychosocial and prognostic markers. Men with localised cancer will be offered the opportunity to participate in a randomised-controlled trial evaluating a telephone-based nurse-delivered, broad reach supportive care intervention. The intervention will provide support for treatment decision-making, managing the side effects of treatment, and stress management with the goal of improving quality of life. This is one of the first Australian large-scale longitudinal studies to track men with prostate cancer from the point of diagnosis and to follow them over time, and the first study internationally to assess this type of supportive care intervention.

It is known that transition from paediatric to adult care in Type 1 dibetes mellitus is often difficult. Young people are anxious about leaving a familiar service. In adult health care they are 'diluted' where Type 2 diabetes mellitus predominates. Australian figures suggest that up to 50% of young adults with Type 1 diabetes are not in specialist care. Failure to engage with specialist care means poor diabetes care and control, and the risk of medium and long term poor health outcomes. We hypothesise that a comprehensive transition program involving communication, mentoring and health professional support will improvement engagement with adult health care better than current clinic practice.This study aims to determine what resources and support are needed to ensure that successful transition occurs. The literature suggest that it is not enough that young people arrive at their first appointment to an adult service; they need to stay engaged and hence the reason for the longer term nature of the study, following young people for up to 18 months after discharge from paediatric servcies

This is a pilot study designed to gather data pertinent to the development of a large scale clinical trial, The study is an open label trial to be conducted over 12 weeks in otherwise healthy individuals. The study will compare baseline Comprehensive Osteoarthritis Test (COAT) measurements with end of study outcomes

The purpose of the study is to determine the efficacy of Evogen® Topical gel in relieving pain in participants with diagnosed osteoarthritis of the knee. The study hypothesies that the application of Evogen® Topical gel four times a day for 1 week will produce a 50% reduction in pain level.

Stem cell transplant recipients will receive an infusion of donor cells at least one month post transplant. Cells will have been stimulated in the laboratory so that they specifically recognise and kill parts of the viruses known as cytomegalovirus and adenovirus.