ANZCTR search results

This study plans to measure mild difficulties in thinking (also known as cognitive impairment) in patients undergoing a coronary angiogram (which is an investigation using x-rays to look at the blood vessels in the heart). It will take measurements of thinking ability before and after the test to see if having the test leads to any changes in thinking ability. We will also ask about health problems related to heart disease such as high blood pressure and smoking.Patients who have heart disease are more likely to have problems with thinking compared with other people of similar age. Studies have also shown that having an angiogram may result in the release into the bloodstream of small particles which may be carried to the brain, potentially worsening thinking ability.We plan to ask 50 patients to participate. We will ask patients who are aged 65 years or older whose doctor has recommended that they have an angiogram,. We will use a computer test called Cogstate to test patients before and after the procedure. The computer tests have been shown to be easy and quick - just like playing a computer game. The testing will take 15 min or so and is done while the patients are waiting for the angiogram to be done. The tests will also be done a week after the angiogram to see if there is any change in thinking ability that may have been caused by the angiogram.

Anaesthesia for Caesarean Section is most often performed by an injection of intra-thecal (spinal) or epidural local anaesthetic. This wears after 2-4 hours after which pain needs to be controlled with other agents. The principal class of drugs used for this analgesia are the opioid drugs (eg. oxycodone, codeine or morphine), all of which cause side effects such as nausea, vomiting, itch and sedation. Bilateral ilio-inguinal blocks (superficial injections on each side of the abdominal wall) have been shown to be effective after general anaesthetic in reducing opioid requirements after Caesarean Section. They are also used routinely for procedures such as inguinal hernia repair. We propose to recruit 120 patients undergoing elective Caesarean Section and randomise them to receive ilio-inguinal blocks with either ropivacaine (a long acting local anaesthetic) or saline (placebo). Those who receive placebo blocks will be given subcutaneous morphine at the end of the procedure (the current standard care). We will review patients at 6 and 24 hours seeking a decrease in pain scores, opioid requirements and opioid side effects.

This study is for patients who have newly diagnosed myeloma to check how effective and safe is velcade.

This trial was abandoned. The original protocol is not available so a brief summary is not available.

The medical, social and economic consequences of dysmenorrhoea are substantial and the prevalence studies emphasise dysmenorrhoea is an important women's health issue. The growing use of unproven complementary and alternative therapies by consumers highlights the need for scientifically rigorous research to identify those complementary and alternative therapies that are effective and safe. The Cochrane systematic review and small controlled trials suggest acupuncture may have a role in alleviating dysmenorrhoea. There is clearly a need for a large, pragmatic, well designed, randomised controlled trial to determine the effectiveness of acupuncture on dysmenorrhoea. The primary hypotheses of this study are that the use of acupuncture in women with dysmenorrhoea compared with sham acupuncture will 1. be effective at reducing their symptoms of dysmenorrhoea as measured by: a) reduced pain and duration of pain, b) reduced need for pain relief, c) an overall improvement in their symptoms, 2. improve their quality of life, as measured by a) improved quality of life indices, b) reduced time off work or from school, c) less restriction on daily life activities, d) less side effects from treatment, The secondary hypotheses of the study are the use of acupuncture in women with dysmenorrhoea compared with sham acupuncture will 1. be effective at meeting women’s expectations as measured by a) acceptability of treatment options for the treatment of dysmenorrhoea.

This randomised clinical trial will assess whether a slower, compared with the standard infusion rate of the loading dose of magnesium sulphate, given to women at risk of very preterm birth at less than 30 weeks gestation for fetal neuroprotection, is effective in reducing maternal adverse effects of treatment.

These data were not published because the quality of the EEG data was very poor. This was due to equipment malfunction.