ANZCTR search results

The purpose of this trial is to determine the effect of high-dose vitamin C on muscle strength, nerve function, gross motor coordination and health-related quality of life in children with Charcot-Marie-Tooth disease type 1A. We hypothesise that muscle strength, nerve function, gross motor coordination and health-related quality of life will be greater in children with Charcot-Marie-Tooth disease type 1A who receive dietary vitamin C supplementation compared to children receiving the placebo.

This study aims to find out if giving a single dose of parecoxib intravenously in theatre improves pain relief following surgery for dilatation and curettage with or without hysteroscopy.

This project aims to work with the NSW Stroke Recovery Association's Stroke Club network to establish and evaluate community -based sustainable exercise programs for stroke survivors. We hypothesis that the experimental intervention ( weekly exercise class and home program for 12 months) will prevent falls and enhance mobility and increase habitual physical activity levels among people following stroke.

Abstract Objective To determine whether giving mothers in Neonatal Intensive Care Unit (NICU) audiorecordings of their conversations with neonatologists improved maternal recall of information and psychological wellbeing. Design: Randomised, clinician - blinded trial with mothers in a NICU either receiving or not receiving audiotapes of their conversations with neonatologists. Participants 200 mothers of babies in a tertiary NICU in North Queensland, Australia Null hypothesis: Providing mothers with an audiotaping of their conversation with neonatologists does not improvetheir recall of infromation about their babies nor the parental well being. Outcome measures: Outcomes (at ten days, four months and 12 months) included recall of information, attitudes towards and use of the audiotape, satisfaction with conversations, post natal depression, parental anxiety, general health and parenting stress. The information conveyed by the neonatologists was coded from transcripts of the audiotapes and matched against the mothers’ recall of the information as measured by interview. All analyses were by intention to treat.

Rifampicin increases bilirubin level in blood, in a small proportion of individual. This is because of deficiency of an enzyme called UGT (uridine diphosphate (UDP)-glucuronosyl-transferase ). The same enzyme metabolizes the chemotherapy drug called Irinotecan. If somebody has the deficiency of the UGT enzyme, they will be at increase risk of toxicity from irinotecan treatment. In this study we are trying to do the same. We will give rifampicin tablets and check whether bilirubin increases or not. Then the irinotecan treatment as scheduled will be given. The side effects from the treatment will be noted. We will try to find if by doing a simple blood test, one can predict if a particular patient is at risk of irinotecan toxicity.

We propose to conduct a randomised controlled trial to compare the effect of eggs to a similar amount of protein and kilojoules from meat fish and chicken in the context of a high protein energy restricted dietary pattern. Primary outcome variables are LDL cholesterol and other cardiovascular risk factors. Our hypothesis is that daily consumption of 400mg dietary cholesterol as 2 eggs compared to an equivalent protein source low in saturated fat and low in cholesterol a kilojoule restricted diet will not adversely affect these outcomes We also propose to opportunistically compare the impact of these dietary patterns on post prandial glucose metabolism, cognitive function and satiety.

Phototherapy is effective in reducing total serum bilirubin (TSB) levels in preterm infants with physiologic hyperbilirubinemia. There is a clear relationship between the dose of phototherapy and the decline in the TSB level. To maximise the dose at a given irradiance, preterm infants are routinely nursed naked whilst receiving conventional overhead phototherapy. It is unclear if efforts to maximise the efficacy of phototherapy by increasing skin exposure achieve an optimal therapeutic response with a minimum of side effects. Conventional phototherapy lights are effective in reducing TSB but not without potential side-effects including increased insensible water loss, persistent patent ductus arteriosus, blunted post-prandial increase in mesenteric blood flow and the possibility of increased cerebral blood-flow velocity. Reports of poor infant regulation and disorganised behavior, early discontinuation of breastfeeding and parental anxiety may be more common side-effects with consequences extending beyond the neonatal period. Such concerns have led clinicians to consider a "kinder, gentler" approach to managing physiologic hyperbilirubinemia in the preterm infant, which includes supporting early positive parent-infant interactions. Providing a supportive environment may facilitate well-regulated infant behavior and positive interactions with parents without prolonging physiologic hyperbilirubinemia and phototherapy treatment. We undertook this study to assess the effect of different skin surface area exposed to conventional overhead phototherapy on TSB levels at 24-hours of treatment. An additional purpose of the study was to obtain information on the incidence of episodes of rebound jaundice, duration of phototherapy, parent-infant interaction and parental stress as well as mean TSB percentage change of infants who continued to require phototherapy treatment after the initial 24-hour period.

The study aims to clarify whether patients on the first cycle of chemotherapy receiving anti-emetics recommended by international anti-emetic guidelines experience a change in mood (especially anxiety and depression) or sleep disturbance. We would also like to determine if there is a difference between anxiety and depression levels and level of sleep disturbance in patients with different cancer types; particularly breast cancer versus non-breast cancer patients. The final aim is to confirm prescribing compliance with international anti-emetic guidelines and assess the control of both acute (first 24 hours after chemotherapy) and delayed (2-5 days after chemotherapy) nausea and vomiting.

Studies in the United Kingdom have shown the feasibility of collecting a standardised core of data with specific criteria for defining disability in children born very preterm at two years of age from questionnaires completed by parents and health care clinicians. Evaluation of outcomes for children born very preterm by questionnaires are very important for the purpose of providing global and epidemiologic information on outcomes, and for planning of services. However, most of the available questionnaires are a subjective assessment of the child and liable to bias. We are proposing the use of questionnaires to collect late morbidity and disability data from the primary health sector in children born very preterm with the support of a structured preterm clinical pathway for screening and surveillance. The pathway has been designed to ensure standardised data collection providing a more objective and valid assessment of late morbidity and disability. It is not designed to replace specialist assessment of a child.

The OVATURE study will compare the investigational drug Phenoxodiol combined with the chemotherapy drug Carboplatin against a placebo combined with Carboplatin. It is hypothesised that Phenoxodiol will reverse chemo-resistance to platinum drugs in late stage ovarian, fallopian and primary peritoneal cancers. For more information on the study and sponsor go to http://www.marshalledwardsinc.com/ or www.phenoxodiol.com