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The study will measure how safe it is to continue with apricitabine treatment long term in people with HIV-1 infection who previously were treated with apricitabine for a shorter period in a previous study

The primary purpose of the GAS study is to determine whether different types of anaesthesia (Spinal Vs General) given to 660 infants undergoing inguinal hernia repair results in equivalent neurodevelopmental outcomes. The study also aims to describe the incidence of apnoea in the post-operative period after both spinal and general anaesthesia for inguinal hernia repair in infants. This study is important as it will provide the greatest evidence for safety or toxicity of general anaesthesia for human infants.

Purpose of the Study: To assess the effect of omega-3 fatty acids on symptoms of mania and depression in children and adolescents with bipolar disorder. Hypothesis: Supplementation with omega-3 capsules will improve symptoms of mania as measured by the Young Mania Rating Scale and symptoms of depression as measured by the Hamilton Rating Scale for Depression in children and adolescents with bipolar disorder.

The ENAR® therapy device is said to combine Western biofeedback with Eastern energy medicine. It is an emerging technology which uses a varying frequency waveform similar TENS, and it alters its resultant frequency spectra according to areas of greater skin resistance. This pilot study investigates the effects of ENAR, TENS and a Sham protocol on 24 non-complicated, chronic neck pain sufferers is conducted.

People with brain injuries often experience problems with prospective memory. Prospective memory is memory to complete future tasks, such as recalling to pick up milk on the way home, or remembering to keep an appointment. It is common for people with poor prospective memory to use a memory device. With improvements in technology increasing the use of Personal Digital Assistants (PDA) in the non-brain injured population, anecdotal evidence suggests that PDAs would allow people with brain injuries to recall important information. Despite their increasing popularity, no studies have determined the effectiveness of PDAs for promoting prospective memory recall after brain injury. Results of the study will provide clinicians with evidence to support or refute the use of PDAs for the management of memory impairment in adults with brain injury.

The prevalence of type 2 diabetes has almost doubled since 1981 in Australia, which has one of the highest rates recorded anywhere in the world. Diabetes carries with it a great excess of suffering, mortality, and health care costs, particularly in relation to cardiovascular disease. Although diet and aerobic exercise have been advocated as the basis of treatment for type 2 diabetes, many older adults find that losing weight is nearly impossible, and aerobic exercise regimens may be difficult to start or comply with regularly. This is often due to other medical problems such as arthritis, foot pain, walking difficulty, cardiac disease, or shortness of breath, all of which are also common in overweight adults. Therefore, diabetic drug or insulin treatment has become the primary management tool of physicians. Drugs do not typically address these underlying problems of fat, muscle and fitness, however, and therefore do not directly change the disease process or the risk of cardiovascular disease. This study will assess the benefits of weight lifting exercise on health status in older adults with type 2 diabetes. Weight lifting decreases fat and increases muscle, while making the body more sensitive to the action of insulin. Although a few studies strongly suggest that weight lifting exercise is very beneficial for diabetes and its associated conditions, there is a need for well-designed, large, long-term trials of this mode of therapy. This treatment regimen, if successful, could simultaneously improve metabolism of glucose and insulin, physical fitness, blood pressure, cardiovascular disease risk, muscle mass, and fat mass, even without an overall change in body weight. Older adults with diabetes will be randomly assigned to either supervised weight lifting or a very low intensity program with no training effect, for 3 days per week for one year, in addition to their usual health care. Measures of disease control and physical fitness will be assessed at 0, 6 and 12 months in all subjects.

This is a study on the benefits of exercise for women with lymphoedema. Who is it for? You can join this study if you have arm swelling following breast cancer treatment, whether this is induced by surgery or radiotherapy. Trial details Participants will be randomly divided into two groups. One group will attend a 60 minutes exercise program three times a week for 10 weeks, aimed at improving upper limb strength The other group will asked to attend for a 30 minute assessment of their lymphoedema each week for 10 weeks (the control group will not have an exercise program). Both groups will have their lymphoedema assessed each week for 10 weeks. The trial looks at any change in upper limb composition measured using a technique known as multifrequency bio-impedance (which is a way to measure tissue density, particularly the amount of fluid in the arm) and arm circumference at 10 weeks and 6 months following completion of treatment. There is no standard intervention recommended for women with arm swelling. The trial will determine the effects of vigorous supervised resistance training on arm lymphoedema. The trial will document whether women with lymphoedema can use their affected arm in vigorous exercise.

To determine how much the melphalan dose used as conditioning for autologous stem cell transplant can be increased when given with Palifermin, and how many more patients can achieve the best response on this increased dose.

The overall aim of this proposal is to demonstrate that blood sugar elevations are minimized through an even consumption of carbohydrates throughout the day. The study aims to clinically evaluate using an energy balanced diet, the effects of an even distribution of carbohydrate across the day in comparison with an uneven distribution on blood sugar elevations and the subsequent degree of hunger. Evaluation will primarily be based on continuous glucose monitoring using a Minimed continuous glucose monitoring system (CGMS) to provide a very detailed picture of the blood glucose profile.

This study addresses the issue of disability among our ageing population. Preservation of function among our older citizens, and their capacity to live independently, is of significant social, public health and economic benefit. The aims of this study are to (1) test the efficacy of Tai Chi in delaying disability among older people, prior to its onset, (2) investigate the mechanisms by which Tai Chi intervenes in the disability pathway, (3) determine the cost-benefits of Tai Chi for older people. The study will recruit 500 people over 70 years of age and randomly assign them to receive either Tai Chi, or a stretching and relaxation program, for a period of 48 weeks. The groups will then be compared to determine if there is any difference in the development of disability as well as a range of functional outcomes such as strength, balance, depression, arthritic symptoms, life satisfaction, and falls.