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EPISODE II: Prevention of relapse following early psychosis
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COMPARISON OF INTRANASAL CORTICOSTEROIDS WITH ALLERGEN AVOIDANCE FOR THE MANAGEMENT OF PERSISTENT RHINITIS
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Phase 1/2 Pharmacokinetic and Safety Study of Oral Phenoxodiol in Patients with Hormone-Refractory Prostatic Adenocarcinoma
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Multicenter Australian Capsule Endoscopy in patients with suspected Crohn's disease Study
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A Phase I/II trial to evaluate gefitinib and concurrent postoperative chemoradiation in patients with advanced resectable head and neck cancer
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Gemcitabine and carboplatin induction chemotherapy followed by concurrent cisplatin and IMRT for locally advanced nasopharyngeal cancer
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Defining interactions between anabolic and peptide hormones: requirement for a robust test for growth hormone doping.
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Can routine N-of-1 studies improve net benefits and reduce costs by better targeting chronic therapy?
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Improving informed consent to clinical trials: Evaluating a decision aid for women invited to participate in a breast cancer prevention trial (IBIS-II).
Expand descriptionThis trial looks at the effectiveness of a 'decision aid' as a means of improving informed consent for women invited to participate in a breast cancer prevention trial (IBIS-II). Who is it for? You can join this study if you are a woman who has had ductal carcinoma in situ (DCIS) or if you have a strong family history of breast cancer, and are considering joining the IBIS-II trial. (This is a study evaluating the role of anastrozole - a drug designed to reduce the hormone oestrogen in the body, in order to reduce the risk of developing invasive breast cancer.) Trial details Participants will be randomly divided into two groups. One group will receive a decision aid plus the standard information sheet, and the other group will receive the standard information sheet alone. The aim of the study is to discover whether a purpose-designed decision aid will increase women's understanding, and make it easier for them to make a decision which fits with their beliefs and values. Standard information includes clear factual information about the disease. A decision aid also provides clear factual information but adds more graphs and pictures and leads the woman through a process of weighing up the pros and cons of trial participation. If this study is successful, decision aids may be used more widely to help people decide whether or not to join a clinical trial.
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The STEAL Study
Expand descriptionCombination antiretroviral therapy for the treatment of HIV has a high pill burden. Two dual-tablets, abacavir-lamivudine and tenofovir-emtricitabine, are now licensed in the United States and will be available in Australia in December 2005. Data available suggest that the potency of these tablets are similar in controlling replication of the HIV virus, but not have not been directly compared in regard to clinically significant toxicities. We therefore aim to compare the overall safety and efficacy of the two dual-tablets over a 2 year period in HIV infected adults. We hypothesise that the two dual-NRTI treatments will be similar in efficacy and safety.