ANZCTR search results

The study aims to identify the benefits of an exercise program for colorectal cancer survivors and look at the benefits of commencing the program immediately following chemotherapy completion. It is hypothesised that the program will be safe and acceptable to the target population and that the exercise program will improve participants' rehabilitation.

Hepatitis B serology will be measured in children born to hepatitis B carrier mothers. Those with low immunity will be given a booster dose of hepatitis B vaccine and have their immunity measured post vaccination

The purpose of the programme is to investigate whether parents improve their psychological and social functioning after completion of a Group Interpersonal Psychotherapy Program. It is thought that participation will improve parent’s psychosocial functioning, social adjustment and general health and this will result in an increase in the amount/quality of positive parental behaviours they implement. Increased positive parenting behaviours will then produce a decrease in child behaviour problems.

Opioids are commonly used for acute and chronic pain management and as an adjunct to anaesthesia. Prescribed opioid-related deaths account for most of non-illicit drug poisoning deaths in America. Death from opioids is nearly always due to respiratory arrest. However, no study has assessed opioid effects on neural-chemical control of breathing during sleep, when respiratory drives are already naturally blunted and protective voluntary breathing is not possible. The present study may meet this gap in knowledge. In addition, this study may reveal whether the potential abnormalities in neural-chemical drive may progress to sleep-disordered breathing.

Hypotension occurs commonly following spinal anaesthesia. It is has been claimed that the standing posture prior to spinal anaesthesia may help prevent hypotension. The aim of this study is to compare two different postures prior to inducing spinal anaesthesia. One group of women will be lying down and the other group of women will be standing up prior to inducing spinal anaesthesia for caesarean section. We plan to measure any differences in the number of women requiring treatment for low blood pressure in the two groups.

We hypothesise that participants receiving a mechanically tensioned ACL graft have superior knee stability and hence function.

To assess whether nebulised heparin limits the extent of lung injury in patients with, or at risk of the acute respiratory distress syndrome.

People with diabetes and atherogenic dyslipidaemia who are treated with statin medication may still be at increased risk of cardiovascular disease and may require combination lipid regulating therapy to further reduce their risk. Endothelial dysfunction and increased arterial stiffness are present in early diabetic vascular disease and may be useful surrogate endpoints for cardiovascular risk. This 30 week, randomised double-blinded crossover study in 25 participants with diabetes who have endothelial dysfunction despite optimal statin therapy, aims to investigate whether combination therapy with micronised fenofibrate 145mg with no-food-effect orally once daily compared to matching placebo improves endothelial dysfunction.

The purpose of this study is to evaluate the effectiveness and safety of a new outpatient chemotherapy treatment for relapsed or treatment resistant (refractory) lymphoma.

The purpose of this study is to determine if SPL7013 Gel (VivaGel™) is safe when applied topically once a day for seven consecutive days to the shaft and glans of the penis in healthy male volunteers. The study will compare the safety of SPL7013 Gel on the penile epithelium and urethral mucosa to the safety of a placebo gel. The study will also assess the systemic safety of SPL7013 Gel, systemic absorption of the active ingredient of SPL7013 Gel, and the acceptability of the study products to the male volunteers.