ANZCTR search results

The purpose of this study is to determine the effectiveness of concentrated intranasal naloxone compared to intramuscular naloxone for treatment by paramedics of respiratory depression due to suspected opiate overdose in the pre-hospital setting. Subjects are unconscious prior to study enrolment, and consent from individuals for study participation is not required.

TENS is a therapeutic non-invasive modality mainly used for pain relief by electrically stimulating nerves via skin surface electrodes. TENS with electrodes over the lower back have also been used successfully to treat the overactive bladder to improve frequency and urgency of urination in patients. The association of treatment for faecal incontinence and urinary incontinence is evident in Sacral Nerve Stimulation (SNS). Based on clinical observation of effect of stimulation on the function of the anus and rectum in urology patients, SNS has been applied in patients with faecal incontinence. The concept is to enhance the activity of the anal muscles via the electrical stimulation of their nerve supply. The usefulness of SNS in faecal incontinence has been confirmed in a number of studies. However, SNS is an invasive procedure. It requires surgery under general anaesthesia to implant a permanent impulse generator under the skin. TENS with electrodes stimulating the same sacral nerves may result in similar benefits. Our hypothesis is that the use of TENS in patients with faecal incontinence may have a therapeutic effect. The advantage of this technique is that it is non-invasive, simple, and cost-effective and has minimal side effects.

The purpose of this study is find out whether zileuton helps to improve the symptoms of children with SLS in terms of skin symptoms (itch), neurology and motor function. patients, parents, investigators and asessors blinded - only central pharmacy will be aware of whether the patient is on placebo or treatment at the time (open label period excepted).

Preterm infants are at high risk of respiratory distress syndrome (RDS) as a consequence of immature lung development. RDS is the principle cause of early mortality and contributes significantly to the high costs of neonatal care. Prenatal corticosteroids substantially reduce the risk of RDS in babies born within 7 days of maternal treatment. Hence, in clinical practice, there has been a tendency to repeat the dose after 7 days in women who remain at risk of preterm birth. However, no formal policy exists. This trial seeks to evaluate the beneficial and adverse effects of repeat doses of prenatal steroids as they may provide a simple, inexpensive way to improve health outcomes for preterm infants. Multi-centre, placebo controlled, double-blind trial. All participants, caregivers, researchers and data analyst are blinded until all prespecified analyses completed. The corticosteroid and saline placebo syringes were identically labelled and the contents masked.

A number of key risk factors for negative outcomes for children following divorce have been identified including enduring co-parental conflcit, poor communication, a decline in ineffective parenting practices.and stress. Family Transitions Triple P is a behavioural family intervention designed to reduce these risk factors. The aim of this study is to evaluate the effectiveness of Family Transitions Triple P . Group facilitators are blind to participant condition.

This study is designed to compare the efficacy of sorafenib in combination with paclitaxel and carboplatin versus placebo in combination with paclitaxel and carboplatin for patients with NSCLC Stage IV or Stage IIIB with pleural or pericardial effusion. Treatments will be blinded to both the investigator and the patient. Double-blinding will be assured by having identical packaging of the sorafenib treatment and the placebo. An interactive voice response system will be used to accomplish allocation of treatment group.

This study is designed to determine whether men with androgen deficiency prefer a long acting injection that requires administration each three months or whether they prefer subcutaneously implanted testosterone pellets administered approximately each 6 months.

This trial is a randomized, double-blind (investigator and patient), multi-center, 2 arm, parallel design study of aprotinin (Trasylol) versus placebo in subjects undergoing selected surgeries on the lung consisting of planned complete primary pneumonectomy or other pulmonary resection with high likelihood of blood transfusion, completion pneumonectomy or decortication for lung cancer, or undergoing esophagectomy (by transthoracic or transhiatal approach) for esophageal cancer. The aprotinin or placebo will be given by intravenous infusion until the end of the surgery.

To determine whether videotelephony is an effective means of improving support during paediatric bone marrow transplantation at a metropolitan hospital

To determine whether videotelephony is an effective means of improving the support provided to regional and remote families receiving paediatric oncology palliative care from a metropolitan hospital