ANZCTR search results

To find the undiscovered gene or genes responsible for hereditary colorectal cancer, and to understand how the gene(s) cause colorectal cancer.

The project was an open label, forced titration dose response study conducted over 5 weeks in 10 healthy smokers and 10 healthy non-smokers. Twenty-two subjects were enrolled in the study and were similarly treated with the study medication. Data was collected at baseline and then each week for a further 5 weeks.

A follow-up study to determine the efficacy and safety profile of a natural medicine formulation in lowering lipid levels in primary hypercholesteremia over a 6-month period. The study also looked at the effect of the preparation on coenzyme Q10 levels.Study blood parameters were measured every 4 weeks

The purpose of the study is to compare the effects of traditional homeopathic treatment, a generic homeopathic treatment with placebo on symptoms of osteoarthritis of the hip and/or knee.

Tablets were self administered by the participants for 14 days. Blood samples were drawn for laboratory analysis and safety measures (full blood count, liver function tests and serum urea, electrolytes and creatinine). Baseline blood was drawn for laboratory measures of study parameters at day 1, day1+3hours, day 13 and day 14. Blodd measured for Ex vivo blood tests Ex vivo blood analysis includes the assessment of changes in the following lymphocyte subsets: ÿ¿ÿ· Mature T cells ÿ¿ÿ· B cells ÿ¿ÿ· Helper/Inducer T cells ÿ¿ÿ· Suppressor/Cytotoxic T cells ÿ¿ÿ· Natural killer cells Assessment of changes in non-specific immune response includes: ÿ¿ÿ· Phagocytosis of granulocytes ÿ¿ÿ· Respiratory burst of granulocytes Assessment of changes in specific immune response includes: ÿ¿ÿ· Lymphocyte activation ÿ¿ÿ· Production of the following 6 cytokines: o IL-2, INFa and INFg for type 1 immune response o IL-4, IL-5 and IL-10 for type 2 immune response

To investigate whether low-dose lithium is an effective agent in indicated prevention amongst subjects at ultra-high risk of developing a psychotic disorder. This aim will be achieved by treating a high-risk patient population with low-dose lithium (450mg/day) and investigating its effects using clinical, neuropsychological, neuroimaging and cell biological approaches. We will recruit 30 patients considered to be at ultra-high risk of developing a first psychotic episode, currently receiving treatment at the Personal Assessment and Crisis Evaluation (PACE) clinic in Melbourne, Australia. PACE criteria for identifying patients at high risk include subjects with a family history of psychosis and a decrease in functioning (30% GAF) AND/OR attenuated psychotic symptoms AND/OR brief psychotic symptoms (BLIPS) resolving without treatment. Patients who give informed consent will receive treatment with a slow release form of low dose lithium for a period of a year, plus supportive therapy. Patients who do not consent will receive supportive therapy only. Assessments will be conducted at baseline, twelve weeks and one year post-recruitment. Assessments will include cognitive functioning, structural MRI, 1H-MRS at 3Tesla and cell biological parameters (bcl-2, AP-1; NIMH, Washington DC). In addition, all patients will be seen on a monthly basis for a clinical interview, covering psychopathology, global functioning, and quality of life.

A randomised non-blinded study was conducted over 4 weeks using a two-step factorial design aimed at obtaining pilot data on the acute effect of essential oils alone and in combination with a back massage on a range of physiological and psychological parameters. The two factors were essential oil and massage. Four conditions were investigated in each participant: sandalwood oil applied with no massage, tea tree oil applied with no massage, sandalwood oil with massage, and tea tree oil with massage. In all cases 10mL of oil composed of 2.5mL active oil and 7.5mL almond oil were rubbed onto the participantÿ¢ÿ¿ÿ¿s back over a five-minute period. Participants then lay supine or were massaged for 30 minutes after the application of the oil. Waking state was maintained over the duration of the treatment. A convenience sample of 15 healthy subject volunteers between 18 and 65 years was recruited and each subject acted as their own control and was tested on all four conditions. Physiological and psychological outcome measurements were taken pre and post each treatment session. Physiological measurements included change in blood pressure, heart rate, skin temperature, oxygen saturation and galvanic skin response. Psychological outcome measurements comprised a self-assessment of well being using 11 parameters, 6 negative and 5 positive.