ANZCTR search results

This study is designed to examine the feasibility of Continuous Positive Airway Pressure (CPAP) treatment for Obstructive Sleep Apnoea (OSA) in acute tetraplegia. This pilot study will examine how well CPAP is tolerated and if treatment is feasible prior to the commencement of any randomised, controlled trial of therapy.

Assessing the impact of exercise (one hour, 3 times weekly on dialysis) using a bicycle ergometer for 3 months, on arterial stiffness (and therefore cardiovascular health) in patients on haemodialysis. Using pulse wave velocity (non invasive applanation tonometry) to measure the changes in degree of arterial siffness

This is a non-randomized cohort study. The purpose of this trial is to compare the side effect profile and their effects on patients treated with 3 different techniques of delivery of curative radiotherapy for localized prostate cancer.We will collect a series of patient-based urinary, bowel, and sexual function scores using validated assessment tools before treatment, 6 weeks and then at intervals after treatment and correlate the results of that with objective, quantitative measurement of patients’ bladder and bowel function using physiologic laboratory tools. This will help us to determine comparative functional effects and understand whether there is a mechanical / physiological explanation for patients’ side effects.

This is a prospective randomised, double blind, placebo controlled trial comparing vaginal prostaglandins E2 gel with an oral synthetic prostaglandin E2 analogue (misoprostol) in the induction of labour at term. Both agents are thought to be equally effective in inducing labour. The main outcomes assessed in this study will be the rate of caesarean section, the number of women who remain undelivered after 24 hours, and uterine hyperstimulation with associated changes in the fetal heart rate. Women, caregivers and outcome assessors (MILO trial) are blinded. For the timing of induction component, it is not possible for women or caregivers to be blinded.

Many small babies <30 weeks gestational age have a very immature respiratory system and require respiratory support for a limited period of time until they mature and can breath by themselves. Continuous positive airway pressure (CPAP) is one such method by which support can be given to these immature babies to allow them to breath without being put on a ventilator or breathing machine. When these babies have matured a little the CPAP is weaned in order to allow the babies to breath without support. This trial will look at 3 methods of weaning CPAP to see which method is most efficient in allowing the babies to breath on their own. The trial has started at Westmead Hospital and we hope to include other Hospitals to increase our numbers in the trial.

To study the pharmacokinetics of DG17 absorption. DG17 is a novel protease inhibitor for the treatment of HIV.

The study hypothesis is that inhibition of cholesterol absorption complements the effects of weight loss on lipid and lipoprotein transport in obese subjects. Specifically , the study aims to elucidate the mechanisms of action of a new therapeutic regimen (weight loss plus ezetimibe) for regulating lipid and lipoprotein transport in these subjects.

The aim of this study is to compare the efficacy of two commonly used clinical exercise interventions for patients with chronic low pain; Swiss ball exercise and floor-based exercise. We hypothesise that there will be no difference between the two exercise programs in terms of improving trunk muscle endurance and lumbopelvic posture.

This study is being conducted in order to see if JetSkins™ reduce ankle swelling associated with flying. There have been other studies on garments very similar to JetSkins™ (compression garments) that show you can significantly reduce swelling in your ankles if you wear these garments during long haul flights (over 5 hours).

Hypothesis: Zinc deficiency potentiates airway inflammation in asthma. This study is to determine if oral zinc supplementation will improve asthma control to enable a reduction in the maintenance dose of inhaled steroids. Blinding is for subjects & assessors.