ANZCTR search results

The aim of the project is to determine whether a water-based exercise training program is effective in improving exercise capacity and health related quality of life (HRQoL) in patients with chronic obstructive pulmonary disease (COPD) in whom co-morbidities may affect participation in land-based exercise. Hypothesis: On completion of an eight-week water-based exercise program, subjects with COPD and co-morbid condition/s will demonstrate significant improvements in exercise capacity and HRQoL. These improvements will be comparable to COPD subjects with co-morbid condition/s completing an eight-week land-based exercise program.

The purpose of this study is to evaluate the safety and feasibility ofa new Patent Foramen Ovale (PFO) closure device. The foramen ovale is a hole in the wall that divides the two sides of the heart. It’s present in the heart of a developing fetus, but normally it closes up soon after the baby is born. If it doesn’t close up, it’s known as a patent foramen ovale (PFO).

To determine the clinical efficacy and safety of moxifloxacin (1.0%) in patients treated with bacterial keratitis compared with patients treated with ofloxacin (0.3%) or fortified tobramycin (1.33%)/cephazolin (5%).

This is a randomised placebo-controlled trial of testosterone undecanoate in obese men with obstructive slee apena as adjunctive therapy for a weight loss programme. The aim of the study is to evaluate the additional effect of testosterone replacement on weight loss and motivation in obese (BMI>30kg/m2) men with obstructive sleep apnea undergoing a weight reduction program. The primary endopint is weight loss after 4.5 months with other secondary endpoints including body composition, anthropometry, physical activity, metabolic markers (eg insulin sensitivity, basal metabolic rate) and blood hormone concentrations.

This study aims to examine the effectiveness of group Mindfulness-Based Cognitive Therapy (MBCT) and standard Cognitive Behavioural Therapy (CBT) as treatments for depression as well as examine the mechanisms of change and predictors of change in both groups. Depressed participants will be recruited and randomly assigned to receive one of the group programs. Both programs will run for 2.5 hours a week for eight weeks. Participants will receive a clinical assessment prior to randomisation and will complete a number of questionnaires before and after the group program and at follow-up assessments at 6 and 12 months. The first pilot phase of the study will assess feasibility and likely effectiveness of MBCT, and pending results will be followed by the second main phase of the study.

This project will assess and optimise the use of telemedicine for asthma management in children and young people across the severity range of asthma to regularly provide asthma education, provide appropriate strategies for asthma management based on the asthma management plan and reminders to take regular medication if prescribed. The use of telephone/SMS technology is highly acceptable to young people and families generally and is readily available across most patient groups.

The primary purpose of the Resilient Families intervention is to help students and parents develop knowledge, skills, and support networks to promote adolescent health and wellbeing during the early years of secondary school. The main hypothesis is that students in the Resilient Families schools will show improvements in family relationships and reductions in depression, substance use and antisocial behaviour relative to the control school students.