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Tenofovir versus Adefovir for the treatment of HBeAg negative chronic hepatitis B
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Tenofovir versus Adefovir for the treatment of HBeAg positive chronic hepatitis B
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A randomised trial of artificial insemination and IVF
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Phase II study of fixed dose rate Gemcitabine-Oxaliplatin Integrated with concomitant 5FU and 3-D Conformal Radiotherapy for the treatment of localised pancreatic cancer: GOFURTGO
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The MAX study
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G-CSF for the prevention of mortality from severe melioidosis in Ubon Ratchathani, Thailand
Expand descriptionRecruitment ongoing at Sappasithiprasong Hospital, Ubon Ratchathani, Thailand
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Glucose normalization Effects on Echo and Novel vascular markers in Acute myocardial infarction
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Effects of natural seaweed extract (GFS) on mobilisation of human bone marrow stem cells and immune system activation
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Text-messages to communicate with young people involved in primary care research: a randomised controlled trial
Expand descriptionTo assess whether text-messaging on mobile phones can be used to communicate with young patients involved in primary care research without affecting the response rate that would be expected from using more traditional research methods such filling out a card and dropping it into a box placed in the practice
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A comparison of two models of spirometry in general practice in the identification and prevention of COPD.
Expand descriptionTo increase recognition of airflow obstruction in primary care, two models of spirometry delivery in a target group at risk of chronic obstructive pulmonary disease (COPD) were compared in a qualitative/quantitative cluster randomised study in eight practices over 6 months; opportunistic spirometry by ‘‘visiting trained nurses’’ (TN) and optimised ‘‘usual care’’ (UC). In the eligible target population of smokers and ex-smokers aged over 35 years, 531/904 (59%) patients underwent spirometry in the TN model and 87/ 1130 (8%) patients in the UC model (p,0.0001). ATS spirometry standards for acceptability and reproducibility were met by 76% and 44% of tests in the TN and UC models, respectively (p,0.0001). GPs valued high quality spirometry and increased testing of patients at risk of COPD in the TN model. They identified limitations, including the need for better systematic follow-up of abnormal spirometry and support with interpretation, which may explain persisting underdiagnosis of COPD in practice records. Conclusions: Although opportunistic testing by visiting trained nurses substantially increased and improved spirometry performance compared with usual care, translating increased detection of airflow obstruction into diagnosis of COPD requires further support.