ANZCTR search results

These search results are from the Australian New Zealand Clinical Trials Registry (ANZCTR).

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33024 results sorted by trial registration date.
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  • Study to Evaluate Efficacy and Safety of Romosozumab Compared With Bisphosphonates in Children and Adolescents With Osteogenesis Imperfecta

    The primary objective of this study is to evaluate the effect of romosozumab treatment for 12-months compared with bisphosphonate(s) on the number of clinical fractures at 12-months; the number of any fractures at 12-months and change in lumbar spine bone mineral density (BMD) Z-score at 6-months.

    Registration number:
    NCT05972551
    Broad health category:
    • Osteogenesis Imperfecta
    Specific health category:
    • Not specified
    Trial focus:
    • Treatment
    Recruitment status:
    • Recruiting
    Recruitment sites:
    • VIC
    • WA
    • Not specified
    Gender:
    • All

  • Pilot Study of ZetaFuse™ Bone Graft for the Treatment of Cervical Degenerative Disc Disease

    The goal of this pilot clinical trial is to test the safety and preliminary performance of the ZetaFuse Bone Graft in patient requiring fusion of the C3-C7 vertebral bones due to pain or loss of neurological function. Participants will be treated with ZetaFuse during surgical intervention to reduce pain and the loss of neurological function.

    Registration number:
    NCT05971329
    Broad health category:
    • Radiculopathy, Cervical
    • Myelopathy Cervical
    • Neurological Abnormality
    • Disc Disease
    • Disc Degeneration
    Specific health category:
    • Not specified
    Trial focus:
    • Other
    Recruitment status:
    • Recruiting
    Recruitment sites:
    • NSW
    • Not specified
    Gender:
    • All

  • Investigate the Efficacy and Safety of BRII-835 (VIR-2218) and PEG-IFNa Combination Therapy in Chronic HBV Patients

    This study will evaluate the efficacy and safety of PEG-IFNa alone or in combination with different dose levels of BRII-835 (VIR-2218) in participants with chronic hepatitis B virus (HBV) infection.

    Registration number:
    NCT05970289
    Broad health category:
    • Chronic Hepatitis B Virus Infection
    Specific health category:
    • Not specified
    Trial focus:
    • Treatment
    Recruitment status:
    • Active, not recruiting
    Recruitment sites:
    • NSW
    • QLD
    • VIC
    • Not specified
    Gender:
    • All

  • A Study of MDI-1228_mesylate Ophthalmic Solution in Healthy Adults

    The main goal of this clinical trial is to evaluate the safety, tolerability and pharmacokinetics (PK) profiles\* of MDI-1228_mesylate Ophthalmic Solution in healthy adult participants. Participants will receive either of the following treatment: * MDI-1228_mesylate Ophthalmic Solution, or * Placebo\*\* Researchers will observe any changes in health (if any) in participants receiving the study treatment to evaluate the safety and tolerability\*\*\* of the study drug. Researchers will also collect several blood samples from participants to study PK profiles of the drug. Note: \*PK profiles: how the drug interacts with the body. \*\*placebo: a harmless substance that contains no active agents. \*\*\*tolerability: how well you can tolerate the drug.

    Registration number:
    NCT05969236
    Broad health category:
    • Allergic Conjunctivitis
    Specific health category:
    • Not specified
    Trial focus:
    • Treatment
    Recruitment status:
    • Completed
    Recruitment sites:
    • SA
    • Not specified
    Gender:
    • All

  • Study of MT-302 in Adults With Advanced or Metastatic Epithelial Tumors

    MYE Symphony is a multicenter, open-label, Phase 1 first-in-human study to assess the safety, tolerability, and define the RP2D of MT-302 in participants with advanced epithelial cancer.

    Registration number:
    NCT05969041
    Broad health category:
    • Epithelial Tumors, Malignant
    Specific health category:
    • Not specified
    Trial focus:
    • Treatment
    Recruitment status:
    • Recruiting
    Recruitment sites:
    • NSW
    • SA
    • VIC
    • WA
    • Not specified
    Gender:
    • All

  • Open-Label Extension (OLE) Study to Assess Safety, Efficacy, and Tolerability of Lorundrostat in Subjects With Hypertension

    This study is to evaluate the long-term safety, efficacy and tolerability of lorundrostat (an aldosterone synthase inhibitor) in subjects with hypertension

    Registration number:
    NCT05968430
    Broad health category:
    • Hypertension
    Specific health category:
    • Not specified
    Trial focus:
    • Treatment
    Recruitment status:
    • Active, not recruiting
    Recruitment sites:
    • NSW
    • Not specified
    Gender:
    • All

  • A Study of Zipalertinib in Patients With Advanced Non-Small Cell Lung Cancer With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions or Other Uncommon Mutation.

    The purpose of this study is to evaluate the safety, efficacy and pharmacokinetics (PK) of zipalertinib in participants with locally advanced or metastatic Non-Small Cell Lung Cancer (NSCLC) harboring EGFR ex20ins mutations and other mutations.

    Registration number:
    NCT05967689
    Broad health category:
    • Advanced or Metastatic NSCLC Harboring Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion (ex20ins) Mutations
    Specific health category:
    • Not specified
    Trial focus:
    • Treatment
    Recruitment status:
    • Recruiting
    Recruitment sites:
    • NSW
    • WA
    • Not specified
    Gender:
    • All

  • Laryngoscopy for Neonatal and Infant Airway Management wIth Supplemental Oxygen at Different Flow Rates (OPTIMISE-2)

    This study aims to investigate the optimal oxygen flow rate needed during tracheal intubation with the C-MAC video laryngoscope (Karl Storz, Tuttlingen, Germany) using Miller-blade or Macintosh-blade size No. 0 or No. 1 in the operating room or intensive care unit. The investigators hypothesize that the difference between low-flow and high-flow supplemental oxygen is negligible.

    Registration number:
    NCT05967507
    Broad health category:
    • Airway Management
    Specific health category:
    • Not specified
    Trial focus:
    • Prevention
    Recruitment status:
    • Recruiting
    Recruitment sites:
    • WA
    • Not specified
    Gender:
    • All

  • Ryme Medical TLD Pilot Study

    Targeted lung denervation (TLD) with the Ryme Medical Lung Denervation System in patients with chronic obstructive pulmonary disease (COPD) - Ryme Medical TLD Pilot Study

    Registration number:
    NCT05967091
    Broad health category:
    • Chronic Obstructive Pulmonary Disease
    Specific health category:
    • Not specified
    Trial focus:
    • Treatment
    Recruitment status:
    • Active, not recruiting
    Recruitment sites:
    • Not specified
    Gender:
    • All

  • Phase III Trial to Investigate Efficacy and Safety of Vilobelimab in Ulcerative Pyoderma Gangrenosum

    A randomized, double-blind, placebo-controlled, multicenter, adaptive phase III trial to investigate efficacy and safety of vilobelimab in the treatment of ulcerative pyoderma gangrenosum

    Registration number:
    NCT05964413
    Broad health category:
    • Pyoderma Gangrenosum
    Specific health category:
    • Not specified
    Trial focus:
    • Treatment
    Recruitment status:
    • Stopped early
    Recruitment sites:
    • VIC
    • Not specified
    Gender:
    • All
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