ANZCTR search results

This trial is the second stage of a two-stage study of the EMVision First Responder Brain Scanner for patients suspected of suffering from an acute stroke in the Melbourne Stroke Unit (MSU). This stage will collect EMVision First Responder scan data matched with stand-of-care ground-truth radiological imaging. Scans are anonymised and enter the EMVision database to support the advancement of stroke-detection algorithms. This study hypothesises that meaningful scan data can be collected in the MSU for the purposes of algorithm advancement.

Paramedics working outside of a hospital do not have access to the same diagnostic and testing equipment that are found in an emergency department, such as x-ray or CT scanner machines. This makes assessing patients more challenging, as there is less information available to aid in determining the severity of illness of a patient. This is particularly problematic for patients with COVID-19, as the condition can vary in its severity. Being able to determine the severity of illness is useful when making a plan for a patient’s ongoing care, such as whether they need to be admitted to hospital or can be cared for in the community. Portable ultrasound devices (known as point-of-care ultrasound, or POCUS) can be used by paramedics to visualise some parts of the lung. As COVID-19 is primarily an infection of the lungs, there are well documented changes to the lung tissues that can be seen on ultrasound. These changes correspond to how severe a COVID-19 infection is. However, ultrasound is a relatively new tool for paramedics and is currently mainly used for assessing patients with traumatic injuries, rather than assessing patients with lung infections. This feasibility project aims to asses if paramedics who have already had training in the use of POCUS can accurately interpret lung ultrasound pictures of patients with COVID-19, when compared to an expert. The results from this study can then be used to inform further research into the development of POCUS as a tool to triage patients with COVID-19, and potentially other lung conditions, in the out-of-hospital environment. This study is being coordinated by a higher degree by research candidate at the Rosemary Bryant AO Research Centre, University of South Australia.

This study will investigate whether a simple urine test, the urinary albumin-to-creatinine ratio (uACR), can help identify intensive care unit (ICU) patients who are developing acute kidney injury (AKI) or whose kidney injury is likely to persist or worsen. Adults admitted to the ICU at Austin Hospital with AKI or at high risk for AKI will have urine samples collected at admission and again at 24 hours. These samples will be tested for uACR and compared with kidney outcomes during the hospital stay. The aim is to determine if uACR can improve early detection and risk stratification of AKI in critically ill patients. Findings may guide future studies and help improve kidney care in the ICU.

Tonsil surgery is one of the most common childhood surgical procedures, however the postoperative recovery is often long and challenging for children and their families. Opioids are a common analgesic following tonsil surgery, and although effective, they have notable side effects including respiratory depression, nausea and vomiting and constipation. This study aims to explore if clonidine can provide comparable, non-opioid pain management to oxycodone for post-operative pain following tonsillotomy.

By estimating the heparin concentration using the relationship between activated clotting time and estimated heparin concentration, it should be possible to improve the ability to reverse heparin at the end of cardiac surgery. The current practice of 1:1 dosing is suboptimal and leads to systematic overdosing. Lower ratios have been shown to provide adequate reversal with reduced bleeding risk. Individualised approaches using point-of-care testing and mathematical models show promise for optimisation, but there are few randomised trials despite widespread clinical use.

This study looks at when beta blockers are given to patients having a CT coronary angiogram (CTCA). Some patients take beta blockers before arriving for their scan, while others receive them once they are in the imaging deparement. The purpose of this study is to compare how these two approaches affect scan preparation and timing. we think that giving beta blockers before arrival will reduce delays and make the process smoother.

This is a Phase 1, four-part clinical trial in healthy adult participants to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of SPT-320, an investigational oral prodrug of agomelatine. Part C is a food-effect crossover study designed to evaluate how a standard meal influences the pharmacokinetics of SPT-320 and Agomelatine.

This study is investigating whether providing different types of information about the costs of a diagnostic test influences ICU doctors’ test-ordering behaviour. You are eligible for this study if you are a registered medical practitioner and have worked in an adult or paediatric ICU in Australia or New Zealand in the previous 24 months. Taking part in this study will involve reading some information about the costs associated with diagnostic testing and a hypothetical scenario describing a patient commonly seen in ICUs. You will then be asked to complete an online questionnaire about which tests you would request for the patient in the scenario and provide some background information about yourself. The findings of this study will inform future projects aiming to improve appropriate testing in the ICU.

This study is investigating whether providing different types of information about the costs of a diagnostic test influences ICU nurses’ test-ordering behaviour. You are eligible for this study if you are a registered nurse and have worked in an adult or paediatric ICU in Australia or New Zealand in the previous 24 months. Taking part in this study will involve reading some information about the costs associated with diagnostic testing and a hypothetical scenario describing a patient commonly seen in ICUs. You will then be asked to complete an online questionnaire about which tests you would request for the patient in the scenario and provide some background information about yourself. The findings of this study will inform future projects aiming to improve appropriate testing in the ICU.

Screen Your Way aims to increase cervical screening participation among under-and never screened Aboriginal and Torres Strait Islander women and people with a cervix. This will be done in partnership with Aboriginal Community Controlled Organisations (ACCHOs) by putting strategies in place to increase self-collection of cervical screening. The ultimate goal is to reduce cervical cancer incidence. The study will work with ACCHOs to co-design ways to increase self-collection, put them into practice, and evaluate how effective they are. The research team will work together with services and their community to develop strategies to support increasing the use of self-collection for cervical screening and other strategies to increase cervical screening. These tailored strategies will be put into practice (implemented) for 12 months. Findings from at least six services in NSW, QLD and NT will be combined and used to inform National scale up of self-collection and help other ACCHOS to roll-out self-collection.