ANZCTR search results

The Holding Hands Program is a parenting program designed to assist parents and carers of young children who are having difficulty parenting. It draws on recent research and treatment evidence about the importance of parent-child relationships and parent emotion regulation for child development. The trial will be delivered at the UTS Family Child Behaviour Clinic within the Graduate School of Health at UTS. The Holding Hands Program will be delivered by provisionally registered UTS Master of Clinical Psychology students in their final year of training. The study will use a within groups design to compare the outcome of treatment as usual with the outcomes from The Holding Hands Program. It is hypothesised that treatment gains will be demonstrated post intervention and at follow-up, and will include statistically and clinically significant change in child and parent functioning. Everyone working on the trial will hold a current NSW Working With Children Check..

Migraine is a significant problem that predominantly affects young women. Hormonal changes associated with menstruation can be a trigger for migraine flares. We are investigating the use of a combined estrogen/progesterone contraceptive pill to see whether it is safe, well-tolerated and effective in treating the symptoms of menstrually-related migraine.

This study explored whether a single-session online Mindfulness-Based Art Therapy Doodling Intervention could support the wellbeing of school teachers in regional Victoria. The two-hour workshop guided participants through mindfulness and creative doodling activities designed to enhance self-awareness, self-compassion, and classroom confidence. The purpose was to evaluate whether this simple, accessible approach could help prevent burnout and strengthen internal coping resources. We hypothesized that teachers would show improvements in mindfulness, self-compassion, and teaching self-efficacy after participating in the session.

This is a Phase 1, open-label, 4-period, period-balanced trial in healthy participants. The trial will investigate the relative bioavailability of 2 formulations (IR tablet and minitablet) of JNT-517 along with the effect of food on the pharmacokinetics of JNT-517. All participants will receive a single dose in a fasted or fed (high fat meal) state.

This study aims to investigate how different amounts of eccentric lunge walking affect physical fitness, muscle strength, balance, mental health, and overall quality of life in adults aged 60 to 80 who are less physically active. We believe that participants who do a higher dose of this exercise will show greater improvements in these health areas compared to those who do a lower dose.

The problem – inpatient harm. Preventable adverse events in Australia’s hospitals are a major safety issue. The magnitude of preventable adverse events coupled with failure to escalate care of deteriorating patients provides strong evidence that existing nursing assessment and management frameworks are not fit-for-purpose. Research is needed to inform the development of an intervention to enhance nursing practice to (a) prevent adverse events, (b) optimise patient experience and (c) improve clinical communication. The aim of this project is to design, implement and evaluate the effect of HIRAID® Inpatient on patient, staff and health service outcomes.HIRAID® Inpatient will be an adaptation of our validated and highly successful emergency nursing framework – HIRAID® (History including Infection risk, Red flags, Assessment, Interventions, Diagnostics, reassessment, and communication).

In this randomised, double-blind, placebo-controlled study, 80 women aged 50 to 70 years experiencing comorbid depressive symptoms and sleep disturbances will be randomly assigned to receive a saffron extract (14mg twice daily) or a placebo for 12 weeks. Changes in depressive symptoms and sleep quality will be examined over time. Moreover, changes in self-evaluations of physical appearance and self-esteem will be examined. Using photos of participants, a skin age application using AI technology will also be used to evaluate changes in facial skin age over time. It is hypothesised that compared to the placebo, saffron supplementation will be associated with greater reductions in depressive symptoms, sleep disturbances, self-esteem and self-evaluations of physical appearance. Moreover, a reduction in facial skin age is also predicted.

This pilot trial will explore the acceptability, feasibility and outcomes of a blended care group program which combines 8 group therapy sessions with a smartphone app, called MyNewWay. The purpose is to evaluate the short-term outcomes of this new blended care intervention for adults with anxiety disorders.

This study aims to evaluate the diagnostic performance of PB-CT in a real-world clinical setting and compare the scans to the standard of care (mammography). Who is it for? You may be eligible to join this study if you are a woman aged 50 - 70 years old, have had a mammogram in the past 6 months with no detected breast cancer and have no metal clips in your breasts. You will need to be able to go to the ANSTO facility in Clayton Victoria and able to lie face-down for a couple of minutes. Study details All participants who meet the eligibility criteria in this study will undergo Propagation-Based Phase-Contrast CT (PB-CT) (intervention) for breast imaging. After the intervention, image quality metrics of the scan will be assessed and participants will be surveyed regarding the comfort of the scan. It is hoped that this research project will help us understand how acceptable this new test is for patients, provide imaging data sets to teach radiologists how to read PB-CT scans, and allow diagnostic quality assessments to be made. Together, this research will help guide future improvements in breast screening and diagnostic imaging for cancer detection and treatment planning.

This study aims to assess the feasibility of a mediterranean meal box for people living with Huntington's disease and their family. We hypothesise the meal box will be safe and feasible for this community. We also expect it to improve cooking behaviours and quality of life.