ANZCTR search results

This study is looking at a new experimental approach for transferring patients from methadone to CAM2038. The purpose of the study is to test if patients with opioid dependence who are treated with a methadone dose of above 30 mg per day to 100 mg per day can be transferred to CAM2038 without reducing the dose of methadone before they start CAM2038. After starting CAM2038 treatment, the methadone dose is then reduced over several days. The main outcome of the study is to see how many participants that proceed to the standard treatment dosing with CAM2038 after one week of treatment with both CAM2038 and methadone. The study hypothesis is that patients can start treatment with CAM2038 without having to reduce their methadone dose below 30 mg before the first dose of CAM2038.

This will be a multicentre (4 Australian HITH services) prospective cohort study where the patient population will be Hospital in the Home (HITH) patients prescribed short term (<2 weeks) continuous antibiotics as an infusion via a Peripheral Intravenous Cannula (PIVC). Patient demographics and comorbidities will be recorded along with prospective data collection on initial PIVC insertion reason and process details, with PIVC and patient outcomes recorded until the time of PIVC removal. A written, short patient survey will also be conducted to establish patient perception and satisfaction of this type of treatment. This means of continuous intravenous antibiotic infusion via a PIVC will be compared to anticipated PIVC complication rates generally (PIVC inserted for any reason) as reported in the literature and to anticipated Peripherally Inserted Central Catheter (PICC) complication rates.

This research study is looking at the ability of the Roche Diagnostics cobas Liat device to reliably and accurately detect Group A Strep (GAS) infection in skin sores. Currently, this device is approved for testing of GAS throat infections. Throat and skin infection with GAS bacteria is common in childhood, but repeated infections can lead to Acute Rheumatic Fever (ARF) and Rheumatic Heart Disease (RHD). Early diagnosis and therefore treatment of GAS infections are key to preventing ARF and RHD, particularly in places with high rates of infections. Analysed and deidentified results from this study will be shared with the study collaborator to support their submission of an application to the Therapeutic Goods Administration to obtain approval for this test to be implemented in clinics for detecting skin infections across Australia.

This study will evaluate a novel intervention designed to help people with a brain tumour better manage their fatigue. Who is it for? You may be eligible for this study if you are an adult with a confirmed diagnosis of a malignant primary brain tumour. Study details Participants will be randomly assigned to either an online program addressing cancer-related fatigue, or an online relaxation program. Both programs will consist of six 30-minutes sessions designed to be completed over 12 weeks. Participants will be asked to complete questionnaires and interviews focused on fatigue self-management and quality of life. It is hoped that findings from this study will contribute towards designing evidence-based interventions to address cancer-related fatigue for people living with a primary brain tumour.

This study aims to test the feasibility of implementing and evaluating blood conservation strategies in blood cancer patients admitted to hospital. Who is it for? You may be eligible for this study if you are an adult inpatient with a haemotological malignancy commencing a chemotherapy protocol. Study details Participants will be randomly allocated to either receive blood conservation strategies (including smaller discard and blood collection volumes) when blood samples are obtained from their Central Venous Access Device (CVAD), or standard of care blood sampling protocols. Questionnaires assessing feasibility and clinical data regarding markers of anaemia will be collected. It is hoped that findings from this study will help determine the impact of hospital-acquired anaemia on patients’ anaemic status and symptoms and will lead to a larger, definitive trial of this.

This pilot trial aims to measure feasibility, accessibility, and efficacy of mindfulness-integrated cognitive behavioural therapy (MiCBT) for adults with ADHD who are experiencing depression and/ or depression. The therapy will be delivered in weekly group sessions and participants will be asked to practice seated meditations twice per day. The guided meditations aim to increase participants' ability to mindfully observe and not react to physical sensations that arise from thoughts and emotions, and then to apply this skill to stressful situations in their own lives, and in line with their own therapy goals.

Inclusion Body Myositis (IBM) is a rare, inflammatory myopathy characterised by progressive weakness primarily in the quadriceps and deep finger flexor muscles. There are currently no disease modifying drugs available to treat IBM. Current therapy is centred around symptomatic management, with exercise a mainstay of the treatment approach. However, information and evidence related to hand exercise is minimal, despite hand grip and finger strength being impacted significantly. This study aims to determine the effectiveness of a 12-week intensive ‘at-home’ hand therapy program using TheraPutty® on hand strength and function for people with IBM. This is a single arm study, with all enrolled participants undertaking the same 12-week hand exercise program. The study will evaluate the impact on strength and function as well as the tolerability and acceptability of the intervention for participants.

This pilot feasibility study will assess delivery of high dose motor retraining through the use of a novel exoskeleton device. The use of robotic technologies can improve upper limb outcomes post stroke, providing stroke survivors with repetitive and task-specific motor retraining. Additionally, robotic technologies can provide opportunities for active practice for stroke survivors with severe upper limb weakness and provide immediate feedback to stroke survivors and clinicians on motor performance, supporting engagement in therapy and providing opportunities to personalise intervention. This study will also provide information on the feasibility and acceptability of the use of this particular technology, which will be used to inform a larger, fully powered clinical trial.

This study is a prospective, single-blinded, randomised controlled trial (RCT) designed to evaluate the efficacy of the ArthroFlex dermal allograft patch augmentation in the surgical repair of large (>2.5 cm) to massive rotator cuff tears. Participants will be randomized (1:1) into two groups: standard repair (control) or repair with ArthroFlex augmentation (intervention). Outcome measures, including MRI-based structural integrity, functional scores and strength analysis, will be assessed at 6-, 12-, and 24-months. Patients and outcome assessors will be blinded to group allocation, while the surgical team performing the procedure will not be blinded due to the nature of the intervention. The primary hypothesis is that patients receiving ArthroFlex augmentation will demonstrate superior pain and functional outcomes, compared to standard repair technique.

The current study seeks to assess if the XPERIENCE® Advanced Surgical Irrigation (XASI) wash can reduce the incidence of Cutibacterium acnes (C. Acnes) pathogen contamination in shoulder arthroplasty surgery. XASI is an antibacterial irrigant employed at the time of surgery, and is currently in use in arthroplasty cases at Hollywood Private Hospital. Recruited patients will be randomized into two groups: 1) specimen swabs taken before receiving 500ml of XASI (Group 1), or 2) receiving 500ml of XASI before specimen swabs are taken (Group 2). Swabs will be taken from six different sites from around the skin incision and surgeon’s instruments. Swabs will then be transported to a single microbiology processing centre for analysis of C. Acnes antibacterial load. It is hypothesized that the XASI wash will reduce the incidence of bacterial contamination of C. acnes in the surgical field of patients undergoing primary shoulder arthroplasty.