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This study aims to test a new way to deliver radiation therapy to people with cancer that has spread to their bones to enhance local control of metastatic lesions while maintaining acceptable toxicity profiles. Who is it for? You may be eligible to join this study if you are aged 18 years and older, are with Pathological diagnosis of a solid tumour, no planned change to main medication on the first day of protocol radiotherapy. You must have a imaging confirmed bone metastases, estimated life expectancy greater than 3 months. Study details All participants who meet the eligibility criteria in this study will be given either: once a day for 5 days over 1 week, or once a day for 10 days over 2 weeks (Monday to Friday, with weekends off unless needed). The treatment includes a standard radiation dose to the affected bone area, along with a more focused, higher-dose boost to the main tumour area using advanced imaging. This boost is designed to better target the cancer while protecting healthy tissue. During and after completion of the treatment participants will be assessed for pain response and patient outcomes using questionnaires, fractures using imaging, and need for reirradiation and salvage surgery to treatment sites through clinical follow-up and medical record review. It is hoped that this research project will help determine if this combined approach is safe, effective, and practical to deliver in routine care to improve pain relief and tumour control while keeping side effects low

Heart failure is one of the most common complications of diabetes. This illness is preventable in the early stages, but few people are detected early enough for prevention to be effective. This trial will identify early stage heart failure using a new Artificial Intelligence (AI) process, and then seek whether exercise training and protective medications can prevent deterioration of function. Hypothesis: The use of exercise training and protective medications in "at risk" patients with diabetes (identified by a new Artificial Intelligence (AI) process) can prevent deterioration of exercise capacity.

This study aims to investigate the feasibility, acceptibility and preliminary effectiveness of a Cognitive Behavioural Therapy for Insomnia smartphone application (called Sleep Ninja®) for improving sleep in autistic adolescents (aged 10 to 16 years) with insomnia. Specifically, we aim to: 1) Evaluate the feasibility of Sleep Ninja through examining recruitment rates, intervention completion rates, reasons for non-adherence and participant retention. 2) Qualitatively assess acceptability, utility, appropriateness and suitability of Sleep Ninja 3) Conduct a preliminary examination of the effects of Sleep Ninja on sleep outcomes including insomnia symptoms, total sleep time, wake after sleep onset, sleep efficiency and time spent in bed, as measured objectively via actigraphy and sleep EEG and subjectively via questionnaires and sleep diaries. It is hypothesised that the digital sleep application (Sleep Ninja) will be a feasible sleep intervention as indicated by high uptake, completion, and retention rates, and that the app will be acceptable to adolescents, and its use will suggest improvement in sleep outcomes.

This study will evaluate whether a structured optometry-led vision assessment and referral pathway (VA-RIS) improves the identification and management of vision impairment in adults admitted for rehabilitation following stroke or falls-related fractures. Participants will be randomly allocated to receive either the VA-RIS intervention or usual care. The intervention includes a comprehensive eye examination during admission and follow-up screening after discharge, with referrals made as needed. The study will assess whether vision problems are more likely to be documented and addressed when the VA-RIS model is used. We hypothesise that the VA-RIS pathway will lead to better identification of vision impairment and improved referral outcomes.

The overall aim of this study is to establish the feasibility of a treatment approach using alternate-weekly dosing of incretin medication for weight maintenance after weight loss.

The primary purpose of this study is to see if titration of statin therapy can improve adherence and therefore outcomes while reducing the known side effects of statin therapy

This study aims to evaluate the feasibility of a mediterranean meal box for people living with Parkinson's disease and their family. It is hypothesised that the meal box will be safe and practical for individuals with Parkinson's disease and their family to use. Furthermore, it is expected that it will promote healthy cooking and eating behaviours and better quality of life.

Polysomnography (PSG) remains as the gold standard for diagnosing sleep-disordered breathing in children as it provides comprehensive monitoring of cardiac, respiratory, musculoskeletal, and neurological functions. However, the procedure’s requirement for overnight hospital stays and skilled personnel poses significant challenges including long wait times, high costs and difficulties in reflecting daily sleep patterns due to the unnatural sleeping environment. Alternatives like smartphone videos and overnight oximetry, though more accessible, lack diagnostic accuracy. This study aims to address these limitations, by introducing a minimally invasive on-mattress device capable of recording body position, acoustic, respiratory and cardiac signals, with oximetry data (via a pulse oximeter) to identify breathing issues during sleep. We hypothesise that this device will simplify and improve the diagnosis of sleep-disordered breathing in children.

Polysomnography (PSG) currently remains the gold standard for diagnosing sleep-disordered breathing in children as it provides comprehensive monitoring of cardiac, respiratory, musculoskeletal, and neurological functions during sleep. However, paediatric PSG requires a 1-night in hospital stay with extensive instrumentation with multiple wires and sensors setup and monitored by skilled personnel. This process poses significant challenges that include long wait times, child and parental distress from the procedures and unnatural sleeping environment, high costs and problems of extrapolating 1-night PSG results to usual sleep at home. Alternatives like smartphone videos and overnight oximetry, though more accessible, lack diagnostic sensitivity, specificity and accuracy. This study aims to address these limitations by introducing a minimally intrusive on-mattress device capable of recording body position, acoustic, respiratory and cardiac signals, along with oximetry data (via a pulse oximeter) to identify breathing issues during sleep in the normal home sleeping environment. Following successful proof-of-concept trials in adults, this study seeks to pilot test the use of this device in children to assess potential clinical utility, feasibility and reliability compared to PSG and overnight oximetry in paediatric sleep medicine care.

The purpose of this study is to determine whether the Growing Screw is a preferable or non-preferable screw compared to the traditional screw in the treatment of Slipped Capital Femoral Epiphysis. Patients will be randomly allocated to each group and will receive the screw through a single surgical procedure. They will then be closely followed-up and information about the two screws will be gathered and statistically compared to determine which is better for long term hip function and pain.