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This study is testing whether a fluoride treatment called Silver Diamine Fluoride (SDF) works better when it is followed by a short burst of light from a dental LED lamp. The treatment will be used on weakened (hypomineralised) molars in children that are planned for removal. We will assess whether using the light reduces sensitivity more than that without the light.

The study is testing a new drug called Tinodasertib to see if it is safe and well tolerated when taken by people who are overweight or obese. The drug is being looked at as a potential treatment to help with weight management. The study will take place at one location and include 64 participants, who will be randomly assigned to one of four groups. One group will get a placebo (a pill with no active drug), the other 3 groups will get either 10mg, 20mg or 30mg of Tinodasertib once a day. Everyone will take their assigned pill daily for 12 weeks, and all participants will also get advice on healthy eating and exercise throughout the study. Before starting the treatment, there is a 3-week screening period to check if people qualify. After the 12-week treatment there is a 3 week follow/up period to monitor participants health.

Health literacy is recognised by the WHO as “a critical determinant of health”. Poor health literacy is known to be associated with a wide range of adverse outcomes, including increased hospitalisation rates and emergency presentations, lower uptake of vaccinations, poor health, and higher risk of death among older people. We validated the HLS-Child-Q15 in English in our VITAL study (RGS5719, ACTRN12622001499774, manuscript in preparation). In the OSTRICH study we want to assess whether a child’s health literacy score as assessed by the HLS-Child-Q15 can predict outcomes after surgery. If outcomes can be predicted by a child’s health literacy score, then the routine assessment of health literacy may be useful in the perioperative management of children and to guide clinical practice when discharging children home after surgery.

This project aims to effectively and sustainably implement midline catheters across Australian paediatric settings and develop a toolkit that is scalable for national implementation. Our vision is to stop unnecessary PIVC pain, complications and reinsertion for children. Over a four-year period, this three-phase project will first co-design an implementation approach, then implement and evaluate it, and finally utilise the findings to develop a national toolkit for change. Phase 1 Co-design of implementation approach to adapt implementation and operational strategies locally, Phase 2 stepped wedge RCT of implementation across regional and tertiary paediatric hospital/wards (study included in this registration), Phase 3 will develop and disseminate a national toolkit for change.

To determine whether acetic acid chromoendoscopy improves the detection rate of sessile serrated lesions during screening colonoscopy in average-risk patients. This outcome is measured by the proportion of colonoscopies that detect histologically confirmed sessile serrated lesion (SSL-DR).

The purpose of this research is to define and identify “consumer-navigation stress” and satisfaction of clinical communication experienced by individuals with Inflammatory Bowel Disease (IBD) as they navigate healthcare systems. By identifying and addressing consumer-navigation stress and assessing communication satisfaction, this research seeks to assess whether the availability of a mobile app can augment care, reduce friction to accessing care, and ultimately improve health outcomes for individuals with IBD. This study will use an IBD-centric consumer designed digital application to improve care navigation, leveraging Crohn's Colitis Care, a bespoke IBD electronic medical record system current in use for over 15,000 patients with IBD across Australia and New Zealand.

This study is testing a new service called the Integrated Peer-Supported Physical Health Service (IPPHS), designed to help improve the physical health of adults living with long-term mental health conditions of schizophrenia, psychosis and bipolar disorder. The service will be offered at adult community mental health clinics in south eastern Sydney and Tasmania and includes support from peer workers, physical health checks with a primary care provider, and a mobile app for health tracking and home exercise. The service for better physical health for people living with persistent mental illness by increasing the number of consumers offered, taking up, and continuing with recommended physical health care.

This is a multi-centre retrospective data collection collaboration with Monash University acting as the co- ordinating organisation. People with epilepsy will be assessed for eligibility through screening of seizure clinic attendance lists and hospital medical records by their recruiting organisations. The recruiting organisations will enter the structured clinical information of their people with epilepsy into the cohort dataset. The data will be de-identified before being provided to Monash University for storage in the data warehouse.

Self-harm is a major threat to health and wellbeing, substantially increasing a person’s risk of suicide. Concerningly, rates of self-harm amongst those under the age of 14 have been increasing rapidly over the last five years. As such, it is becoming increasingly important to target prevention efforts in mid- to late-childhood, before self-harm behaviours emerge. Universal prevention programs are needed to reach all children, regardless of risk. However, no effective universal prevention programs targeting self-harm in young people currently exist. To address this gap, we have developed a new universal, primary school-based self-harm prevention program for students in Years 3-6, called Bridge to Better (B2B). The aim of this study is to evaluate the effectiveness and implementation of the B2B program in reducing self-harm and improving psychological wellbeing amongst students. Up to 6,500 students in Years 3-6 from 72 schools will participate in a cluster-randomised trial to assess the efficacy of the program. Additionally, implementation outcomes will be assessed to determine program adoption and fidelity. It is expected that B2B will reduce the onset of self-harm behaviours and improve wellbeing among students following the delivery of the intervention, and at follow-up. It is also hypothesised that risks for self-harm, including emotional reactivity, depression, negative affect, and bullying will decrease as a result of improved emotion regulation skills and social connectedness among students. If successful, B2B will provide the first Australian evidence-based self-harm prevention program for primary schools.

This study will test whether BRP-180 can improve wakefulness or reduce cataplexy in people with narcolepsy. Participants will be randomly assigned to receive either a low dose, high dose, or placebo, taken once daily for eight weeks. The trial includes a screening and observation period, a treatment phase, and a follow-up to monitor effects. Researchers hypothesize that BRP-180 will significantly improve symptoms compared to a placebo.