ANZCTR search results

Despite huge investments the obesity epidemic persists, treatments are failing and new thinking is urgently needed. Less known is the equally alarming increase in disordered eating – e.g. one in 10 Australians now reports regular binge eating - and the increase in both is more rapid than either alone. Could well-known solutions for disordered eating aid weight loss recidivism? People are known to typically lose weight well to 12 months with the loss plateau commencing thereafter. However, this is the period when intensity of treatment recedes and habitual patterns in maladaptive thinking and behaviours (e.g. binge eating, and emotional overeating) emerge or resurface. We will evaluate outcomes, and their moderators and mediators, following a group-based psycho-behavioural intervention, HAPIFED–M, delivered in this crucial period. This will be embedded in a current service providing opportunities for future partnered translational health care funding. HAPIFED-M incorporates evidence-based treatments for disordered eating as well as a novel cognitive remediation therapy to improve self-efficacy and organizational/problem solving skills. Key outcomes will be improved weight loss maintenance, physical and mental health, adaptive function and reduced health care utilization/costs. Major mediators tested will be reduced eating disorder symptoms and binge eating and an increased capacity for decision making.

The overall aim of the Australian arm of the Seattle Flu Study is to evaluate the accuracy of the flu@home self-test for influenza by recruiting patients who present with an influenza-like illness to a GP or nurse practitioner who is a member of ASPREN for national influenza surveillance activities. Flu@home test results will be compared to PCR test results, which is considered to be the gold-standard for detection of influenza.

Bile acids are increasingly recognised to play a critical role in the regulation of glucose homeostasis. The proposed study extends our novel findings on the effects of exogenous bile acids and capitalises on our capacity to aspirate endogenous bile and target nutrient infusions to specific regions of the small intestine in humans, to define the role of endogenous bile acids in postprandial glucose metabolism in type 2 diabetes (T2DM), and to clarify the relative importance of exposure of different regions of the gut to bile acids. Specifically, we will evaluate the hypothesis that small intestinal exposure to endogenous bile acids will reduce postprandial glycaemic excursions, associated with augmented secretion of glucagon-like peptide-1 (GLP-1) and insulin and suppression of glucagon in patients with T2DM and that these effects will be potentiated by diversion of bile acids from the proximal to the distal small intestine.

The induced blood stage malaria (IBSM) model provides an attractive tool to test the efficacy of vaccines and drugs for non-immune subjects in a rapid and cost effective manner. The purpose of this pilot clinical trial is to characterise the P. falciparum 3D7-GL MCB as a malaria challenge agent for use in future IBSM studies. Another aim of this study is to investigate advanced imaging techniques in malaria infection. Nuclear medicine imaging techniques, particular hybrid PET/CT and PET/MRI have a central role primarily in oncology for assessing the biodistribution and activity of malignancy. The ability of these techniques to detect and locate biological and biochemical changes have more recently been applied to other medical fields including Infectious Diseases, though there are no studies in malaria.

This study will evaluate the safety, feasibility and effectiveness of the YMCA Cancer Survivors’ Program. The program will look at the effects of exercise on cognitive function in patients diagnosed with cancer. Who is it for? You may be eligible to join this study if you are aged 18 years or more, have been diagnosed with cancer (of any type). All participants must have gained medical clearance from doctor with completed medical form. Study details: All participants in the study will receive usual care, which is 12-weeks of waiting performing your normal daily activities. Then all participants will receive a 12-week exercise intervention by a trained YMCA facilitator at a designated YMCA Fitness Centre (current locations: Bowen Hills, Jamboree Heights, Victoria Point). The program will consist of a warm-up, aerobic exercise and resistance based exercise. All exercise interventions will consist of 2 one-hour session per week for 12-weeks in a group-based training session. Cognitive and exercise induced changes will be evaluated through a number of functional assessments, including quality of life questionnaire and physical scans at baseline, post usual care, after the intervention and a follow-up period of 6 and 12-months post intervention. It is hoped that this research will contribute to the growing body of evidence to advocate for all cancer survivors to participate in physical activity. It is hoped that study can assist the YMCA to expand Cancer Survivors’ to other sites and improve the lives of more survivors.

Double blinded randomized controlled trial (RCT) comparing administration of IV albumin versus placebo prior to rescue infliximab in Acute Severe Ulcerative Colitis (ASUC). We hypothesise that administration of intravenous albumin prior to rescue infliximab will increase serum albumin levels and the amount of IFX that is protein-bound, therefore reducing IFX clearance and increasing drug exposure and efficacy.

The induced blood stage malaria (IBSM) model provides an attractive tool to test the efficacy of vaccines and drugs for non-immune subjects in a rapid and cost effective manner. The purpose of this pilot clinical trial is to characterise the P. falciparum 3D7-MBE008 MCB as a malaria challenge agent for use in future IBSM studies.

Study Title Evaluating the translation of an online chronic pain treatment program into clinical practice – can the addition of telephone support improve adherence and outcomes? Objectives Primary: To evaluate the efficacy of the addition of telephone support to the Reboot Online program compared to the usual Reboot Online program treatment in improving adherence to online chronic pain management. Secondary: : To evaluate the efficacy of the addition of telephone support to the Reboot Online program compared to the usual Reboot Online program treatment on outcome measures of chronic pain management. Chronic pain outcome measures will be the Tampa Scale of Kinesiophobia, Brief Pain Inventory, Pain Disability Index, Pain Self-efficacy Questionnaire, International Physical Activity Questionnaire

This prospective single centre randomised, controlled, assessor-blinded study, will investigate the effects of intrapulmonary percussive ventilation (IPV) in non-ventilated patients admitted to intensive care unit (ICU) on their length of stay (LOS), oxygenation and pulmonary complications (mainly pulmonary atelectasis and consolidation) compared to standard chest physiotherapy (CPT). Patients admitted to intensive care unit, who are not ventilated, will be randomised to receive IPV treatment (intervention group) or standard CPT (control group) until discharge from physiotherapy. Outcomes in both the groups will include; number of days in ICU, changes in peripheral oxygen saturation and oxygen requirement pre and one hour post each IPV or CPT session, as well as chest x-rays scores before and after treatment. We hypothesise that participants who receive IPV intervention will have better outcomes compared to participants who receive standard chest physiotherapy.

This randomised controlled mixed methods pilot study aims to 1) compare the relative effectiveness of individualised yoga compared group yoga interventions for reducing depression and anxiety, and 2) to examine how the effectiveness of these two different intervention modalities may be influenced by patient preference.