ANZCTR search results

Participants accessed the website from a link provided in the SONA PArticipants pool for 1st year Psychology students at Macquarie University; OR accessed the link from a skin condition related FaceBook site: OR from a paper-based invitation on view at a Sydney-base dermatology clinic. Once accessing the study website interested participants provided informed consent (online) and were then taken directly to complete the online pre-survey. Immediately after completion of the survey, participants were randomly assigned to either the online self-compassion writing condition or the online control expressive writing condition. Each writing activity took 30mins maximum. Immediately following completion of the assigned writing condition, participants then completed the online post-survey.

The aim of this present randomised controlled trial is to assess the possible effects of 16-week consumption of A2 dairy products, versus conventional dairy products, on symptoms of psychological distress in 90 women with low mood. Secondary aims of this study are to assess possible effects from consumption of these two dairy products on symptoms of depression, anxiety and stress; gut symptoms; gut microbiota; body composition; cognition; well-being; health-related quality of life; and biomarkers of inflammation and oxidative stress. Participants will be randomised to receive either the A2 dairy products (A2 skim milk and full fat cheddar cheese) or conventional dairy products (conventional skim milk and full fat cheddar cheese). Participants are to replace their existing dairy products with the study products and consume at least 250ml of the study milk each day. All other dairy products are to be excluded for the duration of the intervention. Participants will complete in-clinic assessments at week 0,4 and 16 and fortnightly online questionnaires at home. It is hypothesised that 16-week consumption of A2 dairy products will be associated with the reduction of psychological distress in women with low mood at the completion of intervention phase, compared to the consumption of conventional dairy products.

This study will compare two types of thermoplastic retainer materials in terms of their survival rate over a 6month period. It is hypothesised that one of these materials will show an improved survival rate when compared with the other. Secondary outcomes to be assessed include occlusal stability and occlusal settling. These outcomes will be assessed for two different wear regimes (ie; Full time vs Full time; Night time vs Night time) to see whether this significantly impacts on the results. If the retainer types deliver similar occlusal stability and occlusal settling results regardless of the wear regime (as previous research has suggested), then it is hypothesised that survival rate may be improved by only having a night time only wear regime. This would then enable the thermoplastic retainers to have a longer lifespan resulting in less cost for patients/practitioners.

Neurofibromatosis Type 1 (NF1) is a genetic disorder that affects around 1:3000 individuals worldwide. Individuals with NF1 present with a number of different clinical features including a high tumour burden, skeletal abnormalities and learning difficulties. However, low muscle tone, muscle weakness and fatigue associated with NF1 are being increasingly appreciated as major burdens of disease. These can lead to significant functional impairment and reduced quality of life in children, particularly when combined with other features of NF1 such as learning and behavioural difficulties. A 2006 study showed that approximately 30% of all children with NF1 had low self-concept for physical abilities, which continued into adolescence. There is strong preclinical evidence and anecdotal patient reports to suggest that daily L-carnitine will lead to significant improvements in muscle function (particularly fatiguability) and quality of life in individuals with NF1. While tumor burden and risk of malignancy can be devastating for affected individuals, musculoskeletal complications such as muscle weakness, scoliosis, and learning difficulties are the most common quality of life burdens in a pediatric setting. L-carnitine supplementation represents a low impact, low cost intervention that could yield major quality of life improvements in a large number of individuals. The hypothesis to be tested is ‘low dose daily L-carnitine supplementation (1000mg, two divided doses) consumed for 12 weeks is safe and feasible, and will improve muscle strength and endurance in children with NF1.

The purpose of this study is to test if supportive text messages help improve women’s mental and physical health after breast cancer treatments compared to not receiving any messages. Who is it for? You may be eligible for this study if you are aged 18 years or older, have been diagnosed with breast cancer and have completed cancer treatments within the past 18 months. Study details Participants in this study will be randomised (by chance) into two groups. One group of participants will receive four text messages per week at random times and days in addition to their usual care for 6 months. The other group will receive usual care alone for the 6-month period, and will be offered the text message program after that time. A small percentage of participants from each group will also wear an accelerometer on their wrist for 7 days. All participants will complete a number of questionnaires before and after the 6-month period. It is hoped this program will ease women’s transition to managing their health independently after treatments.

The purpose of this study is to determine if physical activity can be safely prescribed for women with metastatic breast cancer. Who is it for? You may be eligible for this study if you are an adult female who has been diagnosed with metastatic breast cancer. Study details Participants in this study will be randomly allocated to one of two treatment groups: 1) Group one will continue with their usual care and be monitored by researchers over a period of 4 months. 2) Group two will take part in an 8-week physical activity program consisting of 2 supervised sessions per week plus a walking program. All participants will also complete a few fitness assessments and questionnaires. Physical activity may be beneficial for improving quality of life and symptom burden. This study will examine whether a supervised physical activity program is safe and feasible for women living with metastatic breast cancer.

Falls are the primary cause of injury for older Australians and cataract, a very common age-related eye condition, increases risk of having a fall. In the BRIGhT study we will comprehensively evaluate integrated surgical and refractive management through public hospital eye clinics to restore vision and prevent falls. This important project will inform the development of new pathways to access cataract surgery and investment in services for the many older people waiting for cataract surgery.

This research project is being conducted to investigate the safety and tolerability of a single application of a transdermal drug delivery system containing fingolimod HCl when administered to healthy volunteers.

The purpose of this study is to determine the role of blood molecules and imaging in the detection of early heart damage in women undergoing radiation treatment. Who is it for? You may be eligible for this study if you are over the age of 18 years, have left sided breast cancer and are undergoing radiation therapy at the Olivia Newton John Cancer and Wellness Centre in Melbourne. Study details All participants in this study will have a blood test on day 1 to 5 of the first week of radiation treatment and then on day 1 of each subsequent week. This will be to measure the levels of blood molecules related to heart damage. Participants will also have a heart ultrasound (echocardiogram) before they start treatment and when they finish treatment. The intention of this study is to identify early damage to the heart muscle during radiation therapy. If we can identify those patients with early damage we can follow them into the future to ensure they do not develop symptomatic heart disease.

This study seeks to compare the relative effectiveness of a multiple shared decision making tools (a preparation video alone vs. enablement intervention alone vs. preparation video and enablement intervention) on consumer outcomes. It will also assess whether the level of health literacy will impact the primary outcomes. Pre-intervention, post-intervention and 1 month follow-up surveys will be used to measure change in primary outcomes. Secondary outcomes will be measured at post-intervention and 1 month follow-up surveys.