ANZCTR search results

This intervention looks to provide the same pain neuroscience education to both groups, while one receives full-body progressive resistance training and the other general calisthenic 'back pain' exercises. The objective is to observe if either intervention better compliments the messages provided with pain education.

The purpose of this study is to assess whether there is a role of non-anaemic iron deficiency in colorectal cancer. Who is it for? You may be eligible for this study if you are an adult who has been diagnosed with colorectal cancer, and are also scheduled to undergo surgery for colorectal cancer. Study details Participants will continue with their current cancer treatment plan, and answer questionnaires in regards to their health over a 3-month period following their surgery. The results of certain blood tests will also be used. These blood tests are taken as part of routine care. You will not be required to have additional blood tests if you are participating in this study. The results of participants with iron deficiency prior to their surgery will be compared to those without iron deficiency. We hope that this study will show that iron replete patients have improved recovery after surgery for colorectal cancer, and enable more widespread research into the role of iron treatments prior to this sort of surgery.

The aim of the study is to assess the efficacy of a natural treatment for the symptoms of the adverse after effects f alcohol. The product Rapid Recovery has been developed based on the scientifically supported rationales using several methods of reducing acetaldehyde ( a major metabolite of alcohol) toxicity which is believed to be a major mediator in the adverse after effects of alcohol consumption. Adverse effects of alcohol consumption will be measured the following day using visual analog scales of validated symptoms. In addition blood alcohol concentrations will be measured prior to commencing the study and at the end of the evening drinking and immediately prior to undertaking visual analog scales. Blood sampling will be performed on the first night of the trial and then on the morning after alcohol has been consumed. There have been reports that that there may be an inflammatory response due to acetaldehyde toxicity.

This project is part of a large program of work involving targeted therapy for obstructive sleep apnoea (OSA) using a novel mandibular advancement split (MAS) in up to 130 participants. The specific goal of arm 2 of this project is to investigate the therapeutic efficacy of mechanism-based targeted therapy (including combination therapy) to treat OSA in people who have an incomplete response to MAS therapy alone (residual apnoea/hypopnoea index [AHI]> 10 events/h sleep). Specifically, we will use sophisticated phenotyping techniques to deliver targeted combination therapy (including oxygen therapy and pharmacotherapy). Accordingly, our goal is to find an individualized treatment solution for all patients. Our goal is to publish the findings from the various study arms including the targeted therapy component throughout the study.

This research project is being conducted to investigate the safety and tolerability of a single application of a transdermal drug delivery system containing memantine HCl when administered to healthy volunteers.

Evidence shows that Vitamin D and probiotic supplementation has a beneficial effect on a child’s immune system. This randomised placebo controlled parallel trial aims to examine the effect of 2-month supplementation with Vitamin D and probiotics on selected physiological and behavioural responses in an infant group at time of their first routine childhood immunisation. This project will assess daily temperature and sleep pattern over two months, and growth, weight at three physician appointments, 4 weeks prior, at the time of vaccination, and 4 weeks after enrolment.

The study aims to examine the relationship between obesity, metabolism, inflammation and the microbiome, and how these are modulated by therapeutic intervention. This will allow identification of outcome predictors pre-intervention. Hypothesis is that obesity, i.e. pathogenesis, clinical phenotype and response to therapy, are driven by dysregulation of metabolic state, gut microbiome and chronic inflammation as well as psychosocial factors.This study will provide novel data in a rigorous, well-characterized large cohort of patients that will enhance our understanding of the function and complex dynamic interplay between the gut microbiome, metabolics, genetics and inflammation.

The EarlyNuts study will recruit a population-based sample of 2.000 12-month-old infants in Melbourne, Australia, to: 1) Measure the current prevalence of challenge-proven peanut, cashew, egg and cow's milk allergy; 2) Measure current practices around introduction of allergenic foods (peanut, egg, tree nuts and cow’s milk) to infants in the population; and 3) Measure the association between age at introduction of allergenic foods and the development of allergy to these foods.

This study is designed to assess the safety and tolerability, pharmacokinetics (how the drug is absorbed by the body) and pharmacodynamics (the effect the drug has on the body) of CT-868 when administered as single and multiple ascending doses in overweight/obese (otherwise healthy) participants and as multiple doses in patient with type 2 diabetes mellitus. The study will start with a low single dose and safety information will be reviewed by a safety review committee to confirm if higher doses can be given to sequential cohorts before giving multiple doses.

The purpose of the research is to investigate young and adult people’s acceptability and satisfaction with a self-management program that aims to help make it easier for people to take their oral cancer tablets and is delivered via smartphone text messages. Who is it for? You may be eligible for this study if you are between 16-75 years old, own a smartphone, and are in either active or maintenance treatment with oral chemotherapy. Study details All participants in this study will receive daily text messages, information on their chemotherapy and information on symptom management, over a 10-week period. Participants will also be asked to complete surveys at the beginning and the end of the 10 week period. This study will help us plan a follow-up study and could help future young and adult cancer patients to more accurately follow their oral cancer treatment, as prescribed by their doctors.