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Acute kidney injury is an increasingly common complication of acute illness in hospitalised patients. In the future, it can lead to chronic kidney disease, end-stage kidney disease, and death. The aim of this study is to investigate whether specialised nephrology follow-up after acute kidney injury is feasible and whether it is effective and reducing the long-term complications of this disease. The specialised nephrology follow-up includes a bundle of care aimed at addressing risk factor for chronic kidney disease and cardiovascular disease.

This study is examining the acceptability of different ways to manage and treat cervical abnormalities diagnosed through the Australian National Cervical Screening Program. Who is it for? You may be eligible for this study if you are aged 25 to 40 years old and are eligible for cervical screening. Study details Participants in this study will complete an online scenario based on a hypothetical doctor visit and cervical screening results. There are four clinical scenarios, and participants will complete one. The scenario will be assigned by chance. The entire exercise takes approximately 20 minutes, and participants will complete a number of questionnaires in the course of the activity. It is hoped this research will inform the development of resources to assist women who are diagnosed with cervical abnormalities to make informed choices with regards to their treatment and management.

Different types of fibre support gut health in different ways. For example, in the large intestine, certain types of fibre are easily broken down by the gut bacteria (through a process called fermentation). Fermentation offers a number of benefits to gut health, but can lead to symptoms in people living with IBS. We have identified several novel types of dietary fibre possessing fermentation characteristics that may be both favourable for gut health and suitable for people living with IBS. The aims of this study are to evaluate the acceptability and tolerability these fibres, the manner that they affect and gut function and whether they are suitable for people living with IBS. To answer these questions, we are asking for both healthy volunteers and those currently living with IBS to participate in a dietary intervention study. This study will involve consuming these novel fibres as part of a regular diet. We aim to recruit a total of 10 participants (5 healthy volunteers; 5 living with IBS). This study will help us better understand how these novel fibres, paving the way for further, clinical trials involving these novel fibres to better understand their potential role in our diets. This study has been initiated by Associate Professor Jane Muir, Head of Translational Nutrition Sciences at the Department of Gastroenterology and will be conducted by Mr. Daniel So as part of his PhD studies.

CodaVax-H1N1, the study drug being researched in this project, is an experimental vaccine being developed by Codagenix, Inc. This means that it is not an approved treatment in Australia, and is not yet approved anywhere else in the world. CodaVax-H1N1 is a vaccine that is intended to prevent influenza. The primary objective of this study is to determine the safety and tolerability of CodaVax-H1N1 influenza vaccine compared to placebo control when administered to healthy adults.

Current recommendations by the Australian and New Zealand College of Anaesthetists professional standards are that quantitative neuromuscular transmission (NMT) monitoring be used in every case of neuromuscular blockade to ensure that the reversal of muscle relaxants is adequate. However, international surveys have demonstrated that as few as 18% of anaesthetists use quantitative neuromuscular transmission (NMT) monitoring routinely. Common (38-64%) and potentially serious complication of general anaesthesia, including respiratory failure, airway collapse, aspiration of gastric contents. Electromyography (EMG) has emerged as the clinical gold standard for NMT monitoring. In particular, Tetragraph is a novel EMG-based monitor that has advantages over older monitors including availability as a stand-alone unit without the need for expensive and specially designed monitors. However, the differences in its electrode design and in-built method for waveform analysis can affect its relative performance to older monitors. Given its recent development, data regarding its relative precision and bias in different muscles of the hand are also lacking. Therefore the hypotheses is that the first dorsal interosseous (FDI) will be more precise and accurate in comparison to the other muscles of the hand and foot and that the Tetragraph, using the train of four ratio (TOF) stimulation of the ulnar nerve under general anaesthesia, will be more precise and accurate compared to the NMT Electrosensor, during spontaneous recovery from non-depolarizing neuromuscular blockade.

This is a randomised, doubleblind, placebo controlled, multicenter study to be conducted across Australia, with an expected study duration of 8 weeks to determine the safety and efficacy of metronidazole ointment. Primary Objective • To determine whether treatment with metronidazole ointment increases healing in subjects presenting with non healing pilonidal disease. Method Patients with non healing pilonoidal sinus wounds will be randomised to one of two treatments or placebo. The wound healing will be measured using percentage improvement in wound size(rate of healing), "PUSH" score and time to healing recorded. Hypothesis Metronidazole ointment increases healing in subjects presenting with non healing pilonidal disease when compared to placebo. The research is a medical / clinical research project which studies the efficacy and safety metronidazole ointment in facilitating resolution of non healing pilonidal sinus.The study design is double blind placebo controlled, randomised control trial.

The aim of this study is to understand the impact of classroom-based active breaks on sitting time, cognitive functioning, brain activity and on-task behaviour in children with neurodevelopmental disorder.

The aim of this study is to understand the impact of cognitively challenging classroom-based active breaks on sitting time, cognitive functioning, brain activity and on-task behaviour in children with typical development.

We plan to determine if, a topical wound gel (Plurogel®), commonly used in chronic wounds and burn wounds, is effective in reducing the amount of bacteria in chronic non-healing diabetic foot wounds, and what effect it may have on the rate of wound healing . By analysing the microbial wound burden prior to treatment start, we will be able to determine what effect the Plurogel has on planktonic (free floating bacteria) and wound biofilm. We will do this using real-time qPCR and 16S rRNA, to identify and quantify the bacterial to human DNA ratio. Scanning electron microscopy will be used to observe the mean amout of biofilm as a reflective marker of intervention efficacy. The most common method to assess infection in a wound is to take a swab of the wound and see what, if any, bacteria grows. The available evidence suggests that taking a tissue sample from a suspected infected wound provides better information about what bacteria is present than taking a wound swab alone. The tissue sample is then provided to a laboratory for them to grow the bacteria. This is currently the standard way that all health care facilities operate. In addition, we also plan to send a piece of the tissue for testing with a new advanced molecular technique, as it has recently been found that trying to grow bacteria in a laboratory may not find all the bacteria that maybe present in a wound. This could explain why some people with high levels of bacteria in their chronic wound do not respond to the standard treatments we provide such as antibiotics and/ or wound care products. Using these new advanced methods will allow us to find all the bacteria in a wound and/or identify certain types of bacteria that don’t grow in laboratories. This may help change the way we treat infections as we can more successfully target particular bacteria, and in turn, this could potentially reduce some of the risks associated with foot infection, like amputation.

This research project will investigate new markers of altered brain structure in various forms of neurodegenerative diseases using 3 Tesla (3T) Magnetic Resonance Imaging (MRI) as well as more highly sensitive 7 Tesla MRI. Each of the neurodegenerative diseases has a characteristic profile (pathology) when the brain is examined under a microscope. Obviously, it is not an option though to remove the brain of a living person for a microscopic examination so we are trying to use MRI brain scans to capture information that could act as indicators for the types of brain pathology that cause these diseases. This is why this project aims to study a range of different degenerative diseases: we predict that the different diseases will be associated with different patterns of change detected with the MRI scans. Standard MRI scans such as those used presently in medical practice cannot make precise diagnoses of specific degenerative brain diseases. In fact, one of the main uses of standard clinical MRI is to rule out non-degenerative diseases such as strokes or tumours. Among the different degenerative diseases themselves, however, standard MRI only provides limited information. In this study, we will utilise a more powerful scanning technology, such as 7T MRI, to provide ultra-high resolution images. This means that we may be able to detect very small tissue changes in the brains that may have not been revealed previously. On the day of MRI scan, participants will be asked to perform some pen and paper tests of their mental abilities (such as memory, thinking, and language) in order to related the scan to their illness stage. MRI scan will take place once these neuropsychological tests are completed. We aim, with this research, to develop new types of MRI scans that may give more information about the precise diagnosis of degenerative brain diseases. As well as improving diagnostic accuracy, we also hope this project may identify new information about how these diseases affect the brain.