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Hypertensive disorders of pregnancy (HDP) complicate 1 in 10 Australian pregnancies, and are associated with an increased medium to long term risk of cardiovascular disease and death, including heart attacks and stroke. However, few initiatives currently target women after HDP to improve their long term health. This multicentre study will assess outcomes of 3 interventions in women being managed after an HDP pregnancy: A. Optimised usual care (CONTROL): Follow-up in primary healthcare and supplied written information B. Brief Education Intervention: One-off individualised risk assessment and education “Brief Intervention” at a specialised hospital postpartum clinic C. Extended Lifestyle Intervention: an individualised “Extended Intervention” comprising a 6 month healthy lifestyle program, commencing six months postpartum 480 women will be randomised to one of the 3 interventions 6 months after HDP, with outcome assessment at 12 months (and plan for 2 and 3 year follow-through assessment). Outcomes: 1) Lifestyle behaviour and/or blood pressure (BP) change 2) Cost-effectiveness and patient acceptability 3) Infant growth trajectory 4) Non-invasive maternal measures of vascular structure and function

In patients with large burns, skin grafts are sometimes not available. Even when they are available, they involve the creation of new wounds and provide wound repair that is not like the skin that has been lost. Fourteen years of work at the Royal Adelaide Hospital have permitted the production of two products (BTM and CCS). BTM is applied to the wounds after the burn has been removed and integrates into the wound. At the same time the CCS is being grown in the laboratory from a small sample of the patient's skin. This takes 5 weeks. When ready, the CCS is applied over the BTM and the wound is healed WITHOUT the need for skin grafts.

The Integrating Pharmacists within Aboriginal Community Controlled Health Services (ACCHSs) to improve Chronic Disease Management (IPAC) project is a large project that will see if including a pharmacist as part of the primary health care team leads to improvements in the quality of the care received by Aboriginal and Torres Strait Islander peoples. The project will be conducted in up to 22 ACCHSs in geographically diverse settings in Victoria, Queensland, and the Northern Territory. A pharmacist will work in each service for 15 months. We expect that patients who are managed in this model of care will experience either equivalent or better health outcomes.

This intervention looks to provide the same pain neuroscience education to both groups, while one receives full-body progressive resistance training and the other general calisthenic 'back pain' exercises. The objective is to observe if either intervention better compliments the messages provided with pain education.

The purpose of this study is to assess whether there is a role of non-anaemic iron deficiency in colorectal cancer. Who is it for? You may be eligible for this study if you are an adult who has been diagnosed with colorectal cancer, and are also scheduled to undergo surgery for colorectal cancer. Study details Participants will continue with their current cancer treatment plan, and answer questionnaires in regards to their health over a 3-month period following their surgery. The results of certain blood tests will also be used. These blood tests are taken as part of routine care. You will not be required to have additional blood tests if you are participating in this study. The results of participants with iron deficiency prior to their surgery will be compared to those without iron deficiency. We hope that this study will show that iron replete patients have improved recovery after surgery for colorectal cancer, and enable more widespread research into the role of iron treatments prior to this sort of surgery.

The aim of the study is to assess the efficacy of a natural treatment for the symptoms of the adverse after effects f alcohol. The product Rapid Recovery has been developed based on the scientifically supported rationales using several methods of reducing acetaldehyde ( a major metabolite of alcohol) toxicity which is believed to be a major mediator in the adverse after effects of alcohol consumption. Adverse effects of alcohol consumption will be measured the following day using visual analog scales of validated symptoms. In addition blood alcohol concentrations will be measured prior to commencing the study and at the end of the evening drinking and immediately prior to undertaking visual analog scales. Blood sampling will be performed on the first night of the trial and then on the morning after alcohol has been consumed. There have been reports that that there may be an inflammatory response due to acetaldehyde toxicity.

This project is part of a large program of work involving targeted therapy for obstructive sleep apnoea (OSA) using a novel mandibular advancement split (MAS) in up to 130 participants. The specific goal of arm 2 of this project is to investigate the therapeutic efficacy of mechanism-based targeted therapy (including combination therapy) to treat OSA in people who have an incomplete response to MAS therapy alone (residual apnoea/hypopnoea index [AHI]> 10 events/h sleep). Specifically, we will use sophisticated phenotyping techniques to deliver targeted combination therapy (including oxygen therapy and pharmacotherapy). Accordingly, our goal is to find an individualized treatment solution for all patients. Our goal is to publish the findings from the various study arms including the targeted therapy component throughout the study.

This research project is being conducted to investigate the safety and tolerability of a single application of a transdermal drug delivery system containing memantine HCl when administered to healthy volunteers.

Evidence shows that Vitamin D and probiotic supplementation has a beneficial effect on a child’s immune system. This randomised placebo controlled parallel trial aims to examine the effect of 2-month supplementation with Vitamin D and probiotics on selected physiological and behavioural responses in an infant group at time of their first routine childhood immunisation. This project will assess daily temperature and sleep pattern over two months, and growth, weight at three physician appointments, 4 weeks prior, at the time of vaccination, and 4 weeks after enrolment.

The study aims to examine the relationship between obesity, metabolism, inflammation and the microbiome, and how these are modulated by therapeutic intervention. This will allow identification of outcome predictors pre-intervention. Hypothesis is that obesity, i.e. pathogenesis, clinical phenotype and response to therapy, are driven by dysregulation of metabolic state, gut microbiome and chronic inflammation as well as psychosocial factors.This study will provide novel data in a rigorous, well-characterized large cohort of patients that will enhance our understanding of the function and complex dynamic interplay between the gut microbiome, metabolics, genetics and inflammation.