ANZCTR search results

This research project is being conducted to investigate the safety and tolerability of a single application of a transdermal drug delivery system containing fingolimod HCl when administered to healthy volunteers.

The purpose of this study is to determine the role of blood molecules and imaging in the detection of early heart damage in women undergoing radiation treatment. Who is it for? You may be eligible for this study if you are over the age of 18 years, have left sided breast cancer and are undergoing radiation therapy at the Olivia Newton John Cancer and Wellness Centre in Melbourne. Study details All participants in this study will have a blood test on day 1 to 5 of the first week of radiation treatment and then on day 1 of each subsequent week. This will be to measure the levels of blood molecules related to heart damage. Participants will also have a heart ultrasound (echocardiogram) before they start treatment and when they finish treatment. The intention of this study is to identify early damage to the heart muscle during radiation therapy. If we can identify those patients with early damage we can follow them into the future to ensure they do not develop symptomatic heart disease.

This study seeks to compare the relative effectiveness of a multiple shared decision making tools (a preparation video alone vs. enablement intervention alone vs. preparation video and enablement intervention) on consumer outcomes. It will also assess whether the level of health literacy will impact the primary outcomes. Pre-intervention, post-intervention and 1 month follow-up surveys will be used to measure change in primary outcomes. Secondary outcomes will be measured at post-intervention and 1 month follow-up surveys.

Our experience with cold calling patients to obtain followup data on their satisfaction with pain management is that some patients were upset by the unexpected cold call. We hypothesized, therefore, that this upset may affect the way that patients respond to the subjective question of satisfaction. We undertook a clinical trial where patients were randomized to consent to participate either in the emergency department or at the start of the cold call. The purpose of the study was to determine if the timing and context of informed consent would confound (impact upon) subjective study endpoints.

This study will evaluate the effectiveness of IMPETUS-D an online simulation training program for staff working in residential aged care facilities (RACF). As the residential aged care workforce is diverse, fragmented and involves shift work, training programs must be engaging and easily accessible. IMPETUS-D aims to reduce transfers to acute hospitals by improving staff knowledge and confidence to deliver end of life or palliative care within the facility, and to enhance consumer satisfaction with palliative care .

Aim: To deliver and evaluate a Mindfulness App (Headspace) in the student population. Study design: This study will be a pilot randomised controlled trial with a waitlist control condition. There will be three measurement occasions: pretest, 6-week post-test, and 3-month follow-up, and they will receive 3 reminder text messages to complete the questionnaires on these 3 occasions. Hypotheses: It is hypothesised that students receiving the Headspace app will have greater reductions in anxiety, depression and stress when compared to the control. App users will also show greater improvements in sleep quality, academic achievement, mindfulness, and self-efficacy.

The study aims to contribute to understanding of the relationship between stress and inflammation. It is thought that, during period of high psychological stress and inflammation, an individual's inner homeostatic system that controls mood and emotional regulation is challenged such that homeostasis is no longer functional. The study will explore whether a mindfulness intervention can aid in the restoration of homeostasis, and, if so, whether this restoration is also associated with a reduction in inflammation, perceived stress levels and symptoms of depression.

Emerging evidence suggests that children get leaner and fitter during the in-school period but become fatter and less fit over the summer holidays. This may occur because of differences in diet and use of time during the holiday period compared with the in-school period (e.g. children may be less active, eat more and have more screen time during the school holidays). However, few studies have tracked diet and use of time across the holiday period. Thus, the focus of the project is to track changes in fitness, fatness, diet and use of time of 9-11 year old children across 3 successive years, and compare rates of change between in-school and summer holiday periods. This study will also assess cross-sectional and longitudinal associations of diet and activity patterns with academic achievement. Findings from this project may inform new, potent avenues for intervention efforts aimed at addressing childhood fitness, fatness and academic achievement.

The aim of this research project is to investigate the effectiveness of the Hunter New England Local Health District (HNELHD) respectful workplace workshops upon creating respectful workplaces for nurses within regional acute care setting. The participants for this study included New graduate nurses, Registered Nurses and Nurse Unit manager in selected hospitals who attended face to face workshops.

This study will determine the efficacy of advanced negative pressure wound therapy compared to a standard dressing protocol in the prevention if surgical wound breakdown following c-section delivery. The benefit of the study is to prevent this complication and improve the health and well-being of the mother following c-section delivery.