ANZCTR search results

This study aims to explore if a telehealth rehabilitation consultation is useful to follow up patients with injury from road accidents after hospital discharge. All patients will receive a telehealth consultation with a rehabilitation physician and allied health professional (1-3 weeks after discharge), to identify rehabilitation needs and receive referral to community-based rehabilitation services. Patients will be followed up at 1 month and 3 months to see how many had rehabilitation needs identified during telehealth consultation and their levels of acceptance/satisfaction with the telehealth consultation.

This feasibility pilot study will compare two methods of delivery, facilitated by a Neuropsychologist or completed independently, for an evidence-based, structured Healthy Brain Ageing (HBA) cognitive training (CT) and psychoeducation program, designed to improve cognitive and psychosocial functioning in people with Subjective Cognitive Impairment (SCI), Mild Cognitive Impairment (MCI) or Parkinson’s Disease (PD). While the program has been shown to be successful in over 350 participants to-date, it has previously only been offered in-person in group-based sessions, which has limited translational capacity. We now seek to evaluate other delivery methods with a view to more readily providing this program to individuals in the community in the future, pending trial outcomes.

This study is testing a combination of a medication called Ibrutinib and infusions of EBV-specific immune cells in the treatment of lymphoma. Who is it for? You may be eligible for this study if you are aged 18 or over and have confirmed EBV positive lymphoma, including Hodgkin-, non Hodgkin-, Systemic, central nervous system and ocular lymphomas. Study details All participants will take orally tablets of the medication Ibrutinib daily for 78 weeks (about one and a half years). In addition to this medication, participants will have 4 infusions, via needle, of virus-specific immune cells. Throughout the study various standard tests will be conducted including blood tests, radiographic imaging and questionnaires. It is hoped this research will demonstrate that these infusions in combination with Ibrutinib will be a safe and effective therapy for lymphoma patients with compromised immune systems.

Fungal infections after receiving a bone marrow transplant is lethal and requires costly anti-fungal treatment . This study will give immune cells to transplant patients to fight the infection. We hope that these immune cells will shorten the amount of anti-fungal drugs required and improve patient outcomes.

This study is a Randomised Controlled trial (RCT) of an online, schools-based, mental health service called Smooth Sailing. This study will evaluate the effectiveness of Smooth Sailing in comparison to a waitlist control group. Smooth Sailing is a service designed to screen and assess the levels of depression and anxiety among secondary high school students. Using a website, students register to the service and then complete an assessment of their mental health symptoms which consists of brief, clinically validated questionnaires. The service then allocates each student to one of five steps for which different online activities are prescribed. The school counsellor is automatically notified by the service when students are allocated to the highest steps, which indicate the most severe symptoms or if or if they report thoughts that they would be better off dead or harming themselves In some way. The school counsellor then follows up with these students in person. This 12-week trial aims to evaluate the effectiveness of the Smooth Sailing service for improving help-seeking as well as reducing symptoms of depression, anxiety, and distress among secondary school students. It is hypothesised students receiving the Smooth Sailing service will report improved help-seeking, reduced distress, depression, and anxiety, when compared to the waitlist control.

This is a commercial study, to assess the effectiveness and dose response of Testofen on muscle strength, endurance and stress markers in exercising females.

The aim of this study is to determine whether midwives can contribute to the provision of contraception, particularly the insertion of Implanon NXT®, in the Australian hospital setting in the immediate postpartum period.. Participating midwives will be provided with training regarding contraceptive counselling, Implanon NXT® insertion, and how to implement this in the postpartum setting. It is standard practice for midwives to insert contraceptive implants in the postpartum period in other countries, however this is most commonly done by medical officers in NSW hospitals, and is not current practice by midwives. It is hypothesised that providing contraceptive training will increase provision of contraception in this setting, and improve confidence of midwives in providing contraceptive counselling and implant insertions. Providing this training to midwives may influence attitudes to contraception provision in this setting, but it is not possible to hypothesise the direction of this change.

This study aims to determine the repeatability of two investigational instruments ( the Lenstar LS 900 and the Triton Swept-source OCT). The instruments are used in optometric research to assess the length of the eye and the thickness of the vascular layer of the eye ( the choroid). To achieve this we wish to take measurements using the instruments over two separate days. The study sample will include a minimum of 15 participants to up to 40 participants with or without refractive errors, we wish to assess the repeatability of the instruments by taking two sets of measurements on two different days.

Preliminary findings suggest aspirin may slow or reduce the rise in core temperature during exercise, improving exercise capacity in individuals with multiple sclerosis (MS). These findings are questionable as the mechanism of action of aspirin does not play any role in active heat production. Cooling interventions like cold water immersion prior to exercise can mitigate heat-related reductions in exercise capacity in individuals with MS. However, many of these interventions are impractical. This project aims to assess the effectiveness of aspirin and skin cooling with a cold water spray on exercise capacity and postural sway in the heat in individuals with MS. It is hypothesised that in individuals with MS, cooling the skin with a cold water spray during exercise, but not ingesting aspirin prior to exercise, will improve exercise capacity and reduce postural sway in the heat.

Heart attack is a major cause of death within the Australian community. Cholesterol blockages in the coronary arteries (the vessels supplying oxygen & nutrients to the heart muscle) are typically responsible for the heart attacks and best seen on a specialized X-ray test that involves injecting dye into these arteries (coronary angiography). Surprisingly, in approximately 10% of heart attack patients, angiography does not show any significant cholesterol blockages. This group of patients is referred to as MINOCA (Myocardial Infarction with NonObstructive Coronary Arteries). The question then arises as to what caused the heart attack in these MINOCA patients? Potential causes include cholesterol plaque rupture, coronary artery spasm or abnormal constriction of the coronary microscopic vessels (coronary microvascular dysfunction). The aim of this study is to determine how often patients with MINOCA have evidence of cholesterol plaques or coronary microvascular dysfunction. Understanding how often these occur and their relationship to heart muscle damages (as seen on cardiac MRI) and symptoms will assist us in developing future treatments for this condition. The microvascular dysfunction assessments and plaque composition assessments will be performed following the standard coronary angiogram procedure and cardiac MRI will be performed within 5 days of the initial admission. All participants will be given informed consent prior to the study participation.