ANZCTR search results

This study aims to compare the effects of Betadine Sore Throat Gargle in decolonising nasal S. aureus, as well as to quantify the decrease in S. aureus numbers and the length of time it has an effect. This will be investigated in a healthy individual population who have persistent nasal colonisation with S. aureus. Three treatments will be compared. A control treatment with nasal application of saline. Mupirocin Nasal Ointment which is currently used for pre operative nasal decolonisation, and nasal application of Betadine Sore Throat Gargle. This is a crossover study design which means that each of the participants will receive all the three treatments. The outcomes examined in this study include to determine the efficacy of nasal application of Betadine Sore Throat Gargle in decolonising nasal S. aureus. To quantify the decrease in colony numbers. To determine the length of time Betadine sore throat gargle has an effect, and to see if it can provide absolute removal of nasal S. aureus. The findings of this study may help establish an alternative method of pre-operative nasal decolonisation of S. aureus.

This is a 2 stage study consisting of an initial open label study in ten (10) healthy volunteers to assess safety and iodine adsorption followed by a randomised, double blind, placebo controlled efficacy study in 258 participants exhibiting the common cold.

The primary purpose of this study is to test the test-retest reliability ad validity of a new scale created to measure the variety support received by students in their PE classes.

The proposed study has as its focus, the important shared role patients can have in determining the outcomes of their healthcare in the context of postoperative recovery after orthopaedic surgery, specifically, total hip replacement (THR). The research program has two major aims: 1) to test a multimedia intervention to improve patients’ participation in their postoperative care; and 2) to model various patient processes of care and system factors that may impact on patients’ overall experience and satisfaction with hospital care after surgery. A nurse-led, multimedia intervention expected to increase both the capability (through information) and opportunity (through facilitation) of patients to participate in their goals of care will be introduced during the immediate postoperative period after elective THR surgery. Advances in information technology, hand held devices and multimedia techniques provide innovative ways to embed nurse-led approaches into the processes of care that can facilitate patients’ participation in their care. A cluster randomised, crossover designed study will be implemented in conjunction with mixed-methods data collection and analysis. The setting will be orthopaedic wards located at a major, private, metropolitan hospital. Patients undergoing primary THR surgery and able to provide consent will be recruited to the study, patients in the cross over groups will receive usual care as per the THR pathway. The intervention will be the application of the nurse-led, multimedia goals of care education package designed to be delivered daily to patients at the bedside by nurses in order to improve patient participation during their recovery. Data collection methods will include patient interviews and patient questionnaires.

This study aims to compare two treatments for the management of Dupuytren's disease of the hand. The two treatments can both be performed in the surgeons rooms without requiring a major surgical procedure. The two treatments are 1) the use of a needle to divide the tissue causing the contracture, and 2) the use of a chemical substance to break down the tissue causing the contracture. The hypothesis of this study is that the use of needle is as effective as the use of a chemical substance, and less expensive.

This research project is being conducted to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of a single 90 mg dose of FlecIH-101 when administered in healthy adult subjects via oral inhalation.

The purpose of this study is to determined how well standard-dose combination chemotherapy works compared to high-dose combination chemotherapy and stem cell transplants in patients with germ cell tumours. Who is it for? You may be eligible for this study if you are 14 years and older and have a germ cell tumour that have either improved or not responded to treatment. Study details Participants will be randomised to one of two treatments: 1. Standard dose chemotherapy: included 4 cycles of chemotherapy every 21 days (including paclitaxel, ifosfamide, cisplatin and pegylated G-CSF). 2. High dose chemotherapy and stem cell transplants: including 2 cycles of chemotherapy (including paclitaxel, ifosfamide and pegylated G-CSF) and 3 cycles of chemotherapy (including carboplantin, etoposide and pegylated G-CSF) plus stem cell therapy. Drugs used in chemotherapy such as those used in this study work in different ways to stop the growth of tumour cells, either by killing the cells, by stopping them from dividing or by stopping them spreading. Those in the high dose group will also be receiving stem cell transplants which should replace the blood-forming cells destroyed in chemotherapy. Blood tests and other physical examinations will be conducted throughout the trial. It is hoped that this research will determine whether high dose combination chemotherapy and stem cell transplants are more effective than standard dose combination chemotherapy in patients with refractory or relapsed germ cell tumours.

The aim of this study is to investigate children's short-term responses to increases and decreases in physical activity above and below usual levels. Children will participate in three, one-off experimental sessions at school. These are: a) Indoor seated play: Children will participate in indoor play activities usually done during wet weather recess and lunchtime; b) Standing lesson: Children will participate in a standing lesson during class time; and c) Sports class: Children will participate in active sport and play activities during class time. The REACT Study will explore whether children ‘compensate’ for being more or less active than they would usually be by being more or less active later on in the day or the next day.

The purpose of this study is to determine the impact of a standardised weaning protocol for high flow O2. The primary outcome measure is the proportion of participants successfully weaned from high to low flow oxygen therapy. The secondary outcome is to determine whether weaning high flow oxygen leads to improved comfort and dyspnoea.

The purpose of the study is to investigate the effectiveness of compassion focused therapy as a treatment for body weight shame associated with obesity. Over the course of a 12 week compassion focused therapy program proposed by the Compassion Focused Therapy: Group Therapy manual by Gilbert, Kirby and Petrocchi (in press); participants will be assessed at pre, post and follow up times across primary and secondary outcome measures. Outcome measures are associated with mental health, compassion, relationship with food, physical health, and process variables.