ANZCTR search results

Following preliminary screening via telephone, potential participants will attend the clinic for an information session and will be required to provide their consent for inclusion in the trial. Consenting participants will undergo a health assessment including lifestyle, current medications and medical history; this data will be used for the comprehensive screening and to provide contextual data for the study. Once enrolled in the trial, participants will be randomly allocated to either one of 2 placebo comparator groups or one of two investigational intervention groups. Prior to treatment, participants will undertake various hair assessments including photographs of scalp (unidentifiable), hair comb/count test, hair tug/pull test, densitometry (haircheck®) and also undertake a blood test. Participants will be asked to consume or apply the allocated product according to the dose prescribed and attend the clinic every month for a repeat of baseline measures excluding the blood test. At week 12 participants will be asked to attend the clinic for a final assessment including all measures undertaken at baseline, a final blood test and an exit interview.

Post-operative ileus (POI) is characterized by impairment of bowel motility and is a common complication after major abdominal surgery in general, and after colorectal surgery in particular. The principal features of POI include nausea and vomiting, inability to tolerate diet, significant abdominal distension and delayed passage of flatus and stool. POI as a complication has the largest overall effect on length of postoperative hospitalization. The purpose of this open-label randomized controlled trial is to determine the effectiveness of stimulant and osmotic laxatives on reducing the duration of postoperative ileus following bowel resection in an optimized Enhanced Recovery After Surgery (ERAS) setting. We hypothesize that in an optimized ERAS setting, using a combination of stimulant and osmotic laxatives post-operatively will result in a reduction in the duration of postoperative Ileus.

The aim of this research project is to evaluate an online mindfulness-based program for people with Multiple Sclerosis. The eight-week program involves five online modules, and mindfulness meditation practice, which will be supplemented by meditation audio-guides and weekly telephone calls with a psychologist. We hypothesize that people with MS who complete this program will improve in symptoms of depression (primary outcome), anxiety, fatigue, and health-related quality of life.

This study aims to test the effectiveness of cognitive behaviour therapy in combination with light therapy compared to relaxation audio. Who is it for? You may be eligible for this study if you are a woman aged over 18, have a diagnosis of primary breast cancer (any stage) and are receiving (or will receive) chemotherapy. Study details Participants will be randomised (by chance) to one of two treatments. One treatment (the Intervention group) is a cognitive behavioural therapy session in addition to use of Light glasses to be worn for 30 minutes each morning. The other group (the Control group) will receive relaxing audio tracks by email. The Control group will receive the information provided to the Intervention group after 3 months. All participants (both groups) will fill out a sleep diary, fill out a questionnaire and wear a watch that measures sleep. It is hoped that this research will help us understand whether a combined behavioural and bright light intervention can reduce sleep disruption and fatigue during chemotherapy for breast cancer and provide a basis for expanding the treatment to people with other types of cancer.

Left ventricular mural thrombus, which is identified in ~5% of patients after anterior ST elevation myocardial infarction, is a major risk factor for stroke. Anti-coagulation with warfarin is the currently recommended treatment. Direct oral anticoagulants (DOACs) such as factor Xa inhibitors apixaban and rivaroxaban, or the direct thrombin inhibitor, dabigatran, have a number of advantages over warfarin, and are an alternative treatment though not currently approved for this indication. There is currently limited randomised evidence to guide management of LV thrombus. This multi-center clinical trial will compare effects of DOACs versus warfarin on LV thrombus resolution and incidence of CV death, stroke, systemic embolism and major bleeding over a 3-month treatment period. Participants will be followed up annually for a period of 3 years to determine long-term health and participant reported outcomes.

The purpose of the study is to investigate the impact that ileostomy site placement has on patient quality of life. This study compares the traditional ileostomy in the right lower quadrant to a minimally invasive ileostomy formed through the umbilicus. The hypothesis is that a minimally invasive ileostomy through the umbilicus is better for the patient as: - There is no damage to the muscle when forming this umbilicus - It's midline position makes it easier for patient's to manage - There is not an extra incision made for this (umbilicus is a common site for port placement during laparoscopic (keyhole) surgery - Patient's are able to sleep on either side due to the midline position

The purpose of this study is to determine whether drowsiness during driving can be detected by using eye blink measures. In particular we are interested in determining whether eye blink measures differ between individuals with sleep apnoea and healthy individuals during their regular driving. Sleep apnoea participants will be matched with healthy participants in respect to age (within 5 years) and gender, It is anticipated that sleep apnoea group will be more tired and this will be demonstrated in their eye blink measures. The study is observational., The main outcome measures are eye blinks, self-reported and measured sleepiness, reaction times and driving habits.

Project GRIT (Growth, Resilience, Insights, Thrive) is a single arm pilot intervention study for children. The program is 12-weeks in length and involves exercise (high intensity interval training), healthy eating and psychological intervention (mindfulness and emotional freedom techniques) for children. The key research question of Project GRIT is: what is the effectiveness of a multidisciplinary intervention involving small-group exercise training and dietary education on metabolic fitness, body composition, cognitive performance, and diet quality in sedentary children aged 9 – 15 years living on the Gold Coast, Australia.

The primary purpose of this study is to validate the quasi-passive knee orthosis' functionality to allow further work It is hypothesized that: - When walking with the quasi-passive knee orthosis, while the leg wearing the orthosis is on the ground, the device will provide bending loads in 2 axes to reduce the loading on the knee. - Hip, knee, and ankle kinematics will remain unchanged. - The quasi-passive knee orthosis will be comfortable for the user to wear for an extended period of time and will have no soreness after use.

The purpose of the study is to investigate the effectiveness of compassion focused therapy as a treatment for body weight shame associated with obesity. Over the course of a 12 week compassion focused therapy program proposed by the Compassion Focused Therapy: Group Therapy manual by Gilbert, Kirby and Petrocchi (in press); participants will be assessed at pre, post and follow up times across primary and secondary outcome measures. Outcome measures are associated with mental health, compassion, relationship with food, physical health, and process variables.