ANZCTR search results

To assess the perioperative analgesic requirements of single dose intraoperative, intravenous methadone versus single dose, intraoperative, intravenous morphine during shoulder arthroscopy.

This study is investigating the effectiveness of new imaging techniques in determining prognosis and treatment response in patients with glioblastoma. Who is it for? You may be eligible to join this study if you are aged 18 years or above and have been newly diagnosed with glioblastoma grade IV, for which your are planned to undergo radiotherapy or combined chemoradiotherapy. Study details All participants in this study will undergo either 2 (group B) or 3 (group A) PET scans, scheduled around their routine radiotherapy, these scans would not normally be part of their routine care. The scans are known as O-(2-[18F]-fluoroethyl)-L-tyrosine Positron Emission Tomography (FET-PET), and involve injection of a radioactive tracer to perform a PET scan. You will need to fast for a minimum of 4 hours before the scan. You will also need to provide a small blood sample when attending for your first PET scan. We will also ask for permission to access tumour tissue samples that were collected during your previous surgery. Participants will be followed up after treatment in order to determine overall survival and disease progression. This information will be used to evaluate the usefulness of the FET-PET scans in predicting prognosis and in identifying treatment-resistant tumours. There are no additional appointments to attend outside your normal treatment visits except for the PET scan visits, which should take approximately one hour. All followup data will be collected from your medical notes when you attend your routine treatment appointments.

This study will determine the effect of a shared care pathway intervention on unplanned presentations to hospital, physical and psychosocial health of chemotherapy outpatients. Who is it for? You may be eligible to join this study if you are aged 18 years or above and have been diagnosed with any cancer (except for haematological cancers) and are commencing the first cycle of chemotherapy as an outpatient. Study details Participants in this study are randomly allocated (by chance) to one of two groups. Participants in one group will receive home visits from a community nurse during the first three cycles of chemotherapy as well as usual care and support from their oncologist and staff at the cancer centre. The community nurse visits will focus on assessment of the patient’s general health, physical and psychosocial wellbeing, with emphasis on chemotherapy-related problems. Participants in the other group will only receive usual care and support from their oncologist and staff at the cancer centre. Participants will be followed up until the end of the third cycle to determine any unplanned hospital presentations, quality of life, physical and other psychosocial health outcomes.

Brown fat, unlike ordinary 'white' fat , functions like generators, burning fat to produce heat and dissipate energy. Brown fat protects animals against cold and from developing obesity. In humans it was previously believed that brown fat disappears after infancy. However, research including our own has shown that brown fat is present in most if not all adult humans and is located mainly around the neck. Brown fat activity in humans is detected by a PET scan based on uptake of glucose that is tagged with a small amount of radioactivity. This is a widely used diagnostic method in medicine. Brown fat is more abundant in lean than in obese individuals. Stimulating its activity may be a simple way of controlling body weight in humans. Apart from the cold exposure, very little is known about what can activate brown fat in humans. Our research aims to identify agents that can activate brown fat in humans. Aldosterone is a mineralocorticoid hormone produced from the adrenal glands. In animals, it was found that aldosterone suppresses the activity of brown fat and blocking aldosterone action by a medication called spironolactone increases brown fat activity. In this study, we will study the regulation of brown fat activity by spironolactone in humans and its metabolic significance

This study tested potential treatments for Australian children who have severe problems learning to read. Some of poor readers find it hard to read via the letter-sound rules (phonics), some find it hard to read whole words by sight (sight-word reading), and many have both of these problems. In this study, one group of poor readers (N = 41) did 8 weeks of specific phonics training (i.e., reading via phonological decoding) and then 8 weeks of specific sight word training (i.e., reading via recognition of irregular words from memory). A second group of poor readers (N = 44) did the reverse order of training. The results showed that both specific sight word training and specific phonics training had large and significant valid treatment effects on trained irregular words, untrained irregular words, and word reading fluency; and that specific phonics training had an additional large and significant valid treatment effect on reading comprehension. These findings demonstrate the reliability of both phonics and sight word training in treating poor readers. This will aid Australia’s efforts to counteract the effects of poor reading in children by revealing how different treatments should be tailored to children with different types of reading impairment.

People with diabetes are vulnerable to diabetic retinopathy (DR); a common complication that damages the blood vessels at the back of the eye. The early stages of DR are asymptomatic; early detection via eye examination and timely treatment are important in reducing the risk of vision loss. National Health and Medical Research Council recommend eye examinations at diabetes diagnosis and minimum every two years thereafter. Some at-risk groups have unacceptably low eye examination rates, including adults with type 2 diabetes (T2DM) who are i) 18-39 years or ii) from rural/regional Victoria (eye exam rates are 50% and 65% respectively). The aim of this project is to develop communication messages designed to increase eye examination rates for people from the two at-risk groups. Presented in leaflet format, the messages will be mailed to eligible registrants on the National Diabetes Services Scheme (NDSS). It is hypothesized that participants who have not previously had an eye examination and who receive a psycho-educational leaflet intervention containing theoretically derived messages demonstrated to correlate with the target behaviour will report: a. Increased intentions to seek eye examinations, and b. Higher rate of eye examinations than control group participants, at follow up.

The purpose of this study is to determine if markers in the airways or blood can predict when someone with mild/moderate or severe asthma is at risk of developing an acute asthma attack associated with a virus infection. This may allow us to better determine who needs treatment to prevent attacks of asthma and for how long.

This project aims to investigate the potential beneficial effect of a natural plant food compound (quercetin), on blood vessel function in adolescents with Familial Hypercholesterolaemia (FH). FH is a common genetic disorder affecting many thousands of children and adolescents throughout Australia, that elevates blood cholesterol from the time of birth, predisposing them to heart disease in early adult life. Untreated, 50% of men and 20% of women will have suffered a fatal or non-fatal cardiovascular event (ie heart attack) by the age of 50. Children with FH have highly compromised blood vessel function. Whilst medications like statins will lower cholesterol levels and can help improve blood vessel function, there is general reluctance among physicians and parents to commence children with FH on statins before the age of 18 years, because of a lack of long-term follow up studies on the use of these medications in younger patients. Thus, a nutrition-based supplement that could improve blood vessel function in children and adolescents with FH prior to them going on long term statin therapy would be of benefit. Using non-invasive ultrasound, we will investigate the effect of consuming a drink containing the natural plant food compound quercetin on how the blood vessel functions in 10 adolescents with FH aged 13-18 years. This will be compared to a placebo drink that contains a harmless sugar compound. We expect that the plant food compound will have a beneficial effect on blood vessel function in this population and lead to a potential new treatment option.

Aspiration pneumonia or pneumonitis is a fatal complication under general anaesthesia. Current fasting guidelines before general anaetshesia recommend 2 hours for clear fluid and 6 hours for light meal. However the guidelines do not account for the fact that some fasted surgical patients may still not have empty stomachs at that time of their surgery. The technique of gastric ultrasound to determine the types of gastric contents and the volume has been well described and standardised. The hypothesis of this study is gastric volume will return to baseline more rapidly after ingestion of clear fluid as compared to a fluid equivalent of a standard meal.

The 'Fit4Two - Usability and initial efficacy testing of a website-delivered behaviour change intervention. The Fit4Two study is a 4 week pilot 2-arm RCT investigating the acceptability, feasibility and preliminary efficacy of a behaviour change intervention designed to promote exercise among women during pregnancy. Participants will be recruited from the Rockhampton region of Australia through collaboration with partnering organisations. The primary outcome is weekly physical activity levels measured using valid and reliable accelerometers. The trial will be conducted and reported according CONSORT guidelines. Participants randomly allocated to the Fit4Two intervention group will receive a web-based intervention, which will provide them with personalised advice based on information derived from an online assessment. Participants randomly allocated to the control group will receive usual care, access to the resources library of the program, but no computer-tailored feedback. The program will be delivered at no cost to participants. Participants will now also receive resources and referrals to other programs, services, and avenues for support. Each program participant will be provided with tailored physical activity advice and feedback to help them make a positive lifestyle change, which inturn might improve their health and the health of their baby and reduce chronic disease. All respondents will be clearly informed that they SHOULD NOT participate in the study if they believe it may be unsafe or unhealthy for them to do so. This screening procedure has been used by similar studies. No adverse events have occurred. There is substantial evidence that increasing physical activity is safe and leads to health benefits rather than health damage in pregnant women. The information provided to participants will be evidence-based and reflect the physical activity guidelines for pregnant women. The trial will be aimed at pregnant women in their second trimester. The benefits (the evaluation of a potentially effective physical activity intervention that might improve health outcomes among pregnant women and their child) of this research largely outweigh the minimal risk to participants. Should there be any unanticipated difficulties, all participants are provided with contact details for the principal researcher.