ANZCTR search results

Investigation of infra-red oculography-generated drowsiness feedback as a fatigue mitigation tool for drivers

Cardiovascular Disease (CVD) and Major Depressive Disorder (MDD) are the two leading causes of disease burden in developed countries. Both conditions are highly prevalent amongst older Australians, and frequently co-occur. In patients with comorbid CVD and depression, treatment for depression is effective in improving depressive and cardiac symptoms, as well as reducing mortality risks. The current study aims to determine whether a novel internet-delivered treatment for major depression, which is cost-effective and amenable to widespread dissemination, is similarly effective. The current study will also be the first to explore the causal pathways underlying reductions in cardiac events and mortality risk following treatment for depression. In order to address these aims, older (>50 years) individuals with comorbid CVD and depression will be recruited from the St Vincent’s Hospital Heart and Lung Outpatients Clinic. Participants will be randomly assigned to receive clinician-assisted internet-delivered cognitive behavioural therapy (iCBT) for depression (n=50) or treatment as usual (n=50). Relative reductions in depressive and cardiac symptoms between the intervention group and control group will be compared immediately post-treatment, whilst 6 month follow up of the intervention group will establish longer term benefits of the intervention.

This study will aim to observe the short- and medium-term effects of a broccoli-enriched diet on the activity of CYP1A2, CYP2C19, CYP2C9, CYP2D6 and CYP3A4 in men of European and South Asian ancestry. It has been hypothesised that the broccoli-enriched diet will initially reduce the activity of these CYP-isoforms and increase their activity after 6 days of consumption.

The purpose of this study is to demonstrate that neurostimulation increases tear production and improves symptoms of dry eye disease over baseline measurements.

This project will investigate the efficacy of a manualised theoretically driven oral narrative programme. Intervention will involve explicitly teaching macrostructure to 12 Pre-Primary children with narrative difficulties in small groups in a mainstream school. Multiple baseline repeated measures single-case design will be used to evaluate changes. Measures will include narrative macrostructure, microstructure and quality. The relationship between vocabulary and memory and response to intervention will also be investigated. This study has practical and theoretical significance as it will add to evidence for narrative intervention focusing on macrostructure and investigate the influence on vocabulary and sentence development.

This project will design, develop and investigate efficacy of a manualised theoretically driven oral narrative programme. Intervention will involve explicitly teaching macrostructure to 12 Pre-Primary children with narrative difficulties in small groups in a mainstream school. Multiple baseline repeated measures single-case design will be used to evaluate changes. Measures will include narrative macrostructure, microstructure and quality. The relationship between vocabulary and memory and response to intervention will also be investigated. This study has practical and theoretical significance as it will add to evidence for narrative intervention focusing on macrostructure and investigate the influence on vocabulary and sentence development.

The purpose of this study is to examine the effects of nightly administration of a standard dose of a common sleeping pill (sedative) zopiclone, over one month, on sleep apnoea severity, symptoms of daytime sleepiness, and measures of alertness in sleep apnoea patients

This study is evaluating whether mailing a human papillomavirus (HPV) self-sampling kit will increase participation in cervical screening. Who is it for? You may be eligible to join this study if you are a Victorian woman aged between 30-69 years with no record of a Pap test in the Victorian Pap Test Registry (never screened) or the last recorded Pap test was at least 5 years ago (underscreened). Study details: The National Cervical Screening Program based on conventional Pap test has substantially reduced deaths from cervical cancer; however, some women are missing out on the benefit because they do not have regular Pap tests. A new method of screening has recently become available. This is based on testing for human papillomavirus (HPV), which is the virus that causes cervical cancer. Because women can obtain their own HPV sample at home, this test has the potential to overcome some of the reasons why women don’t have Pap tests. Participants in this study will be randomly (by chance) allocated to one of two groups. Participants in one group will be mailed an invitation letter and a testing kit, which includes an information brochure, HPV self-sampling kit, instruction sheet, pathology information form and a reply paid envelope. Participants in the other group will receive a reminder letter to attend for a Pap test, which is standard practice in Victoria. We will evaluate the proportion of women in each group who participate in screening, the proportion of women with a positive screening test who undergo appropriate further investigation, and women’s experiences with self-sampling over a period of 12 months.

Hospitals and health systems spend millions of dollars each year on dressings to secure Central Venous Access Devices (CVADs) to patients’ skin. Nurses and doctors spend hours applying and maintaining them; yet 20-40% of CVADs fail prior to treatment being complete, including many that partially or wholly ‘fall out’, become occluded or infect the bloodstream. The proposed study is a randomised control trial, designed to (i) identify clinical, cost-effective methods to prevent CVAD failure due to infection, occlusion, migration and accidental removal; (ii) to compare usual care dressings, with three novel methods; and (iii) to evaluate the acceptability of these devices to patients and health professionals.

Assess the intraocular pressure (IOP) reduction induced by the STARflo glaucoma implant in eyes with open angle glaucoma. Absolute success is defined as an IOP < 21mmHg and > 5mmHg with a minimum 20% IOP reduction from baseline without the need for glaucoma medication. Qualified success is defined as an IOP < 21mmHg and > 5mmHg with a minimum 20% IOP reduction from baseline with the concomitant use of glaucoma medication. This is a prospective, single centre study of the CE marked and TGA approved STARflo glaucoma implant. Patients with open angle glaucoma requiring surgical reduction of IOP will be screened for suitability for inclusion in the study. Following implantation of the STARflo, participants will be followed for a minimum 12-months.