ANZCTR search results

This is a study to determine whether using a remote vital sign monitoring application improves the care in patients being treated with highly myelosuppressive chemotherapy at home. Who is it for? You may be eligible to join this study if you aged 18 years or above and are being treated with highly myelosuppressive chemotherapy. Study details Participants in this study will be using the remote vital sign application device at home for during the time when their white cell count is low (usually day 8-14 of the chemotherapy cycle). The remote vital sign application will be attached to the skin by a patch adhesive and it will monitor vital signs such as body temperature and heart rate. During this time, oral thermometer measurements will also be taken manually and recorded on a data sheet. Information from the device and the manual oral measurements will be collated after the white cell count has recovered, and the patch is removed.

The aim of the project is to evaluate the impact of a brief, intensive seminar on positive parenting for parents who are divorced. The seminar is specifically developed to address risk factors and enhance protective factors for parents who are divorced. It aims to enhance parental coping, communication, and conflict management skills as well as reduce dysfunctional parenting styles and parental adjustment issues. The seminar also aims to encourage parents to build skills and competencies in their child that will enable the child to successfully negotiate high-risk environments, and enhancing their child’s resilience.

The planned study is a pilot study performed in order to obtain baseline data for a larger randomised study in which we plan to compare bleeding time, amount of bleeding, local temperature and blood flow over the puncture sites between a hypnotised and non hypnotised arm of the same volunteer.

To assess the visual performance of prototype soft contact lens designs compared to a commercially available contact lens.

Approximately one percent of pregnancies result in a death during the perinatal period, which extends from 20 completed weeks of gestation until 28 days after birth. The causes of unexpected death during this period range from obvious gross structural abnormalities, placental dysfunction and transplacentally-acquired infections, to cases where there is no apparent reason for the early demise of the fetus or neonate. A percentage of these perinatal deaths that have no detectable gross structural abnormalities may, for example, occur due to underlying cardiac channelopathies, cardiomyopathies and potentially, some forms of epilepsy. Such conditions at a development stage may not leave any clinically significant characteristics at autopsy such as histological abnormalities detectable with light microscopy or anatomical changes normally observed with MRI. In essence, this study is an extension to the usual genetic analysis component of our perinatal autopsy protocol, enabled by a new technology that is currently maturing. Thus, the rationale of this trial is to provide more information on the cause of perinatal death and improve the clinical management of families whose babies have died during the perinatal period.

Depressive disorders are highly prevalent and are the leading cause of disability in young people worldwide. While there is an increasing evidence base regarding effective treatments for youth depression, interventions that are recommended by the Australian clinical practice guidelines, such as cognitive behavioural therapy (CBT), are only modestly effective in this age group. There is an urgent need for additional treatment strategies to treat current problems as well as prevent the onset of secondary or comorbid mental disorders and disability. One such strategy that has an emerging evidence-base is physical activity as an augmentation or adjunct treatment. Physical activity is a low-stigma intervention with few side effects, factors that are important to help-seeking young people. This project aims to evaluate the effectiveness of a brief physical activity intervention that is integrated into usual clinical care in reducing depression and increasing engagement in physical activity in help-seeking young people. All allied health professionals at selected headspace centres (enhanced primary care youth mental health services) will be invited to take part in the project and those who participate will be offered training in the delivery of the intervention and a treatment manual. All help-seeking young people aged 12-25 years who present to the selected headspace centres will be screened for eligibility to participate in a cluster randomised controlled trial (RCT). Clinicians will be randomised to be trained in and to deliver either the physical activity intervention (active condition) or the psychoeducation (control condition) in addition to routine clinical care. Young people who consent to take part will be allocated to receive treatment from a clinician who has been randomised to deliver either the physical activity intervention or psychoeducation on physical activity in addition to treatment as usual. The primary hypothesis is that the physical activity intervention will lead to greater reductions in depressive symptoms compared to treatment as usual. The secondary hypothesis is, a) that the physical activity intervention will lead to: i) reduction in anxiety symptoms; and ii) improvements in functioning, when compared to treatment as usual; b) that changes in depressive symptoms will be mediated by increased physical activity.

Research has shown that only few adults with Autism Spectrum Disorder (ASD), particularly those without intellectual disability, participate in the competitive workforce. Many studies have identified the need to develop vocational support programs to enable individuals with ASD to participate in and retain employment. However, there is limited research detailing the impact of workplace environmental factors in employment and the potential successful employment outcomes that may occur from modifying the environment through the use of an ASD specific tool. The overall aim of this research project is to develop the Integrated Employment Success Tool (IEST) which will be used to adapt the workplace environment to facilitate successful employment outcomes for adults with high functioning autism/ Asperger Syndrome.

This study aims to determine whether DHA supplementation during pregnancy enhances child IQ, measured by the Wechsler Abbreviated Scale of Intelligence (WASI II) version II, at 7 years of age. hypthesis: Children who were exposed to a DHA-rich environment during the second half of gestation will have higher IQ scores at 7 years of age than children whose mothers consumed a regular Australian diet typically low in DHA.

This pilot study will provide information regarding effect sizes, distribution of results and the feasibility of comparing two PR approaches: a PR approach in which the MECT is added to the PR assessment to further tailor the intervention and a PR approach that will not require this MECT information. Data from this pilot study will inform the investigators regarding the design of a larger multi-centre RCT to evaluate the effectiveness of both exercise prescription approaches in pulmonary rehabilitation

The current research project aims to investigate the efficacy and acceptability of the Pain Course when delivered via a hardcopy workbook (wCBT) versus in a softcopy format via the internet (iCBT). Importantly, given that many Australians still do not have reliable access to the internet, if efficacious and acceptable, workbook delivery represents another simple, low cost, approach for increasing access to evidence-based treatment for people with chronic pain.