ANZCTR search results

This is a randomised, double-blind, placebo-controlled, ascending dose study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of EMP-012, and how this drug acts in the body in healthy volunteers. EMP-012 may be indicated for use in patients with Chronic Lung Disease, but a trial of the drug in healthy volunteers is needed before trials in Chronic Lung Disease patients can proceed. Who is it for? You may be eligible for this study if you are aged 18 to 65 years and are in good general health without a clinically significant medical history. Study details All healthy volunteer participants who choose to enrol in this study will be assigned by chance to receive either a single dose of EMP-012 or placebo. All participants will have their vital signs checked (heart rate, blood pressure, temperature, etc), and will provide blood and urine samples for testing. It is hoped this research will determine the maximum dose of EMP-012 that can be administered safely without causing severe reactions. Once the dose of EMP-012 has been determined in healthy volunteers, a trial investigating the efficacy of EMP-012 as a treatment for patients with Chronic Lung Disease may proceed.

We propose to test a promising model of care for individuals with persistent LBP that provides immediate access to a psychologically based and internet-delivered pain management intervention in addition to usual care from physiotherapists and chiropractors. While the current study is dedicated to determining feasibility and acceptability of this model of care, we do hypothesise that this approach will broadly be sustainable, scalable, enhance clinical outcomes, economically efficient, improve access to healthcare resources, and increase the capacity of the health system to deliver multi-disciplinary care.

This project aims to develop and then pilot the following: (i) An evidence-based risk stratification algorithm for use by home care staff to identify deteriorating aged care clients who are at high fall-risk, drawing on recently available guidelines, followed by; (ii) A structured mobility and falls assessment, using evidence-based tools, able to be delivered rapidly by a virtual (i.e., telehealth / videoconference enabled) consultation with an AHP aided by a member of the clients’ usual care team being present in the client’s home.

Understanding the effect of intoxication on witnesses is important to the legal system, but there are key gaps in our knowledge in this area. While the research on alcohol and memory is advancing (e.g., see Jores et al., 2019), there is still little known on other substance effects in an eyewitness context. Specifically, there is minimal research on amphetamines and event memory, and no known research on any type of amphetamines and their impact on face recognition in a line-up context. This leaves many remaining questions and gaps which this study aims to fill as itpertains to dosage, timing, expectancy effects (i.e., anticipating potential substance effects that influence performance). Furthermore, many crimes are distressing in nature, however minimal research has explored intoxication and memory in the context of a distressing event. The role of stress must also be addressed because stress hormones are released during amphetamine use. This requires research about whether stress and amphetamine intoxication combine to impact memory. Additionally, it is unclear whether alcohol use will reduce the stress response, or whether stress will lead to a pause in alcohol metabolism, and how either of these may interact with memory. Study hypotheses: it is anticipated that alcohol may impair memory completeness but not accuracy, whereas it is possible that dexamfetamine may improve memory. An exploratory aim is to investigate whether stress impacts drug response (e.g., makes drug effects more or less pronounced and subsequently impacts memory accordingly).

This study aims to explore whether an audiovisual medium is more effective than written information for patients seeking information necessary for informed consent for robotic-assisted radical prostatectomy (RARP). Who is it for? You may be eligible for this study if you are aged 18 years or older, you have been diagnosed with prostate cancer and you have been scheduled to undergo a robotic-assisted radical prostatectomy. Study details All participants who choose to enrol in this study will be randomly allocated by chance (similar to flipping a coin) to one of two groups. Participants allocated to the first group will be asked to watch a 10 minute animated video about the robotic-assisted prostatectomy procedure prior to answering questions about the procedure and the consent process. Participants allocated to the second group will be asked to read an information pamphlet about the robotic-assisted radical prostatectomy via a website prior to answering questions about the procedure and the consent process. It is hoped this research will determine whether presenting prostate cancer patients with audio-visual information about a complex surgical procedure allows patients to develop a greater understanding of the procedure compared to traditional written pamphlets.

Chronic pain is one of the most common, distressing, and burdensome forms of disability in Australia, with around 20% of Australians experiencing chronic pain (>3 months) at any one time. Chronic pain is associated with markedly reduced quality of life, high levels of distress and often co-occurs with depression, anxiety, fatigue, sleep disturbance and relationship strain. Some studies have found an association between a low histamine diet and reduced migraine and other symptoms. This study aims to assess to assess the impact of an exogenous histamine-reducing dietary intervention on pain as measured by the Brief Pain Inventory (BPI) 1 month after commencing the low histamine diet, and the cost effectiveness of the intervention.

ChatGPT is a publicly available AI chatbot that is free, easy to use and gives quick, human-like responses to user questions and requests. However, sometimes the information it gives is incorrect, missing key information, or unsafe. In this online study we want to test two social media interventions to see if they help people use ChatGPT more safely when asking health questions. Participants will be allocated to one of three groups: image carousel (instagram tiles), animation (short video) or control (health eating infographic). After viewing the intervention we will ask participants which kinds of questions they would try asking or avoiding asking ChatGPT.

Surgical insertion of a reversed total shoulder replacement in patients with arthritis and torn muscles and tendons. The use of a wedged base plate in reverse shoulder replacement allows easier positioning of the socket part of the shoulder joint and less removal of bone .

Suicide is the leading cause of death among Australians aged 15-24 . Increasing our understanding of risk factors and developing novel indicated interventions to reduce deaths by suicide is urgently needed. In this project, we aim to develop and test the acceptability, feasibility and safety of a novel psychological intervention for young people with suicidal thoughts, that specifically targets a distressing form of suicidal thoughts that has been underrecognized in both clinical practice and research to date: mental images of suicide. One promising psychological intervention for treating intrusive and distressing mental images is imagery rescripting. Imagery rescripting involves individuals focusing on the content of their intrusive and distressing mental images and then vividly imagining an alternative outcome. This image is generated and rehearsed with a therapist. No previous studies have used imagery rescripting to directly target suicide-related mental images and to assess the effectiveness of this intervention in young people, for whom suicide is the leading cause of death. In this pilot study we aim to examine whether this intervention is acceptable, feasible, and safe in a small pilot study.

This study aims to validate a finger prick test against a peripheral blood test to measure 5-fluorouracil blood levels, so that finger prick testing could be done at home in future. Who is it for? You may be eligible for this study if you are an adult male or female receiving a 46-hour infusion of 5FU as part of your treatment for cancer. Study details Participants will return to hospital on Day 2 of their infusion to have a consecutive finger prick test and a peripheral blood test. Patients can participate in the finger prick and peripheral blood testing for more than 1 cycle of treatment. The correlation between 5-fluorouracil plasma drug level in a finger prick test compared to a peripheral blood test will be measured, and participants will be asked to complete an evaluation of the finger prick instructions. It is hoped that findings from this study will validate finger prick testing to replace peripheral blood testing so that testing can occur at home.