ANZCTR search results

This study sought to test the feasibility and limited efficacy of using textured insoles in children with motor coordination concerns following 4 weeks of use. Outcomes suggest there is support for running a larger trial with non-statistically significant trends showing greater improvements in balance outcomes for the insole group and greater endurance outcomes from the shoe alone group. The project was conducted in line with the protocol as approved by the University of South Australia HREC

Smoking is the leading cause of preventable death in people with severe mental illness (SMI). Although smokers with SMI want to quit, tailored interventions are rarely delivered in practice. This pilot feasibility study will assess the acceptability of the QuitPick intervention for smoking cessation among individuals living with severe mental illness. 30 participants who are accessing any treatment, support or care service for a mental health condition from Mind Australia Limited in Victoria will be recruited. All participants will receive the QuitPick intervention. Participants will be contacted by Quitline and offered a targeted smoking cessation counselling intervention with a choice of pharmacotherapy (NRT or NVP) and peer support over a 12-week period. Assessments will be conducted at baseline, 3 months (end of treatment), and 6 months (3 months post-treatment). After completing the QuitPick intervention, one-on-one semi-structured interviews will be conducted with 20 participants to investigate the experience of participants and understand acceptability of the intervention, with a focus on further enhancing engagement with the intervention.

Dialectical behavior therapy (DBT) is one of few evidence-based interventions for disorders of recurrent binge eating, yet few have access to this specialized approach. Translating DBT content for delivery via a smartphone application presents a scalable solution, yet no existing DBT app for recurrent binge eating exists. The aim of this trial is to test the efficacy of the Resilience application in individuals with recurrent binge eating. It is hypothesized that Resilience will produce greater improvements in all primary and secondary outcomes than the control condition.

This study aims to understand whether different types of knee sounds are associated with knee issues. We also would like to understand perceptions that people have regarding their creaky knees and usefulness of an Exercise Physiology assessment session for their knee function and health. The study will ask people, with/without knee osteoarthritis, to attend a 1-hour knee assessment session at the University of Sydney. In this session knee health will be assessed, knee sounds recorded, and exercise advice provided. Three months later the participants will be interviewed about their knee health and if they found the AEP session useful.

The purpose of this study is to determined whether the addition of a PET scan to conventional CT scans improves the diagnostic accuracy and/or changes the management for patients newly found to have a kidney tumour. Who is it for? You may be eligible if you are an adult who has recently been diagnosed with a kidney tumour. Study details PET scans work by injecting a "tracer" that accumulates in specific tissue types and show as "hot spots" on a scan. We will be comparing two types of tracer that have been shown to have affinity for renal tumours: Prostate-Specific Membrane Antigen (PSMA) and Fludeoxyglucose (FDG). As such all participants in this study will be asked to have both a PSMA PET and an FDG PET within 21 days of enrolment. The scans may be performed on the same day, or require different visits. There is a small risk of bruising or infection at the injection site. Each scan involves a small radiation dose which is within safe limits. Participants will also complete a health-related quality of life questionnaire at enrolment and after completing the scans. It is hoped that this study will determine whether PET scans will improve diagnostic accuracy both by identifying areas of tumour not seen on CT, and by ruling out areas that are suspicious on CT.

Anal high grade squamous intraepithelial lesions (HSIL) are caused by high-risk human papillomavirus (HRHPV) and may develop into anal cancer. Anal cancer is rare in the general community, however people who live with HIV (PLHIV) are at higher risk. Anal HSIL is detected by high resolution anoscopy (HRA). The PANTHER study aims to evaluate the effectiveness, acceptability, and tolerability of electrocautery treatment in PLHIV with persistent intra-anal HSIL.

People with mental illness often have to accept medication and other treatments in the community through the use of community treatment orders (CTOs). Yet forced treatment remains one of the most contentious issues in mental health service delivery; its efficacy is unresolved, its usage is irregular and unequal, and it raises serious ethical and human rights concerns. Responses to these debates must be informed by valid and reliable data. This study will be the first to investigate the justifications for CTOs across Australia to allow greater understanding of the variance in rates of CTOs and enable appropriate action by stakeholders. The primary aim of this study is to analyse data on the sociodemographic and clinical features of people on CTOs across Australia comparing similar services across Australia to understand the wide variation in their use nationwide.

People with mental illness often have to accept medication and other treatments in the community through the use of community treatment orders (CTOs). Yet forced treatment remains one of the most contentious issues in mental health service delivery; its efficacy is unresolved, its usage is irregular and unequal, and it raises serious ethical and human rights concerns. Responses to these debates must be informed by valid and reliable data. This study will be the first to investigate the justifications for CTOs across Australia to allow greater understanding of the variance in rates of CTOs and enable appropriate action by stakeholders. The primary aim of this study is to understand differences in sociodemographic, clinical and health service use patterns (hospital and community) between individuals discharged onto CTOs compared to voluntary treatment.

This study aims to assess whether use of a new near infrared imaging device (PTeye device) during thyroid and some parathyroid operations enables surgeons to confidently identify parathyroid glands. Who is it for? You may be eligible for this study if you are aged 18 years or older, you have been diagnosed with thyroid disease, including primary hyperparathyroidism and thyroid cancer who will be undergoing thyroid or parathyroid surgery for exploration and/or tissue removal purposes. Study details Participants who choose to enrol in this study will be randomly allocated by chance (similar to flipping a coin) to one of two groups. Both groups will undergo their scheduled thyroid/parathyroid surgery per standard procedures, however one of the groups will also have their tissue imaged using the PTeye device. It is anticipated that use of the PTeye device will add 5 minutes to the overall procedure time. It is hoped this research will determine whether use of the PTeye device enables surgeons to more confidently identify parathyroid tissue during surgery. By assisting the surgeon in correctly identifying parathyroid glands, this device may improve the quality of the operation performed on the patient.

The aim of this study is to determine the feasibility, safety, and acceptability of short-term humidified flow therapy (myAirvo 3TM) in people living with respiratory conditions in the SESLHD community. The hypothesis is that myAirvo 3 is feasible, safe and acceptable to be used in the community and will assist sputum burden and/or breathlessness.