ANZCTR search results

The study aims to investigate the effects of different plant extracts on prolonging satiety in healthy overweight adults. This study utilizes a randomized, double-blinded, crossover design to investigate if specific plant extracts can reduce appetite and increase feelings of fullness. Participants will attend an initial screening and five treatment sessions at the BASE Facility. The primary goal is to understand if these extracts affect how much people eat at lunchtime, while secondary outcomes assess changes in appetite through questionnaires.

This study is to evaluate the potential of tumour organoid response to predict the clinical benefit that individual patients will derive from available anti-cancer therapies for advanced CRC, in the first- and later-line therapy settings. Who is it for: You may be eligible for this study if you are an adult male or female with a diagnosis of CRC that is either locally advanced and unresectable, or metastatic, have not received treatment (ie chemotherapy) for this stage of disease and otherwise are fit enough to undertake treatment. Study details: The study will involve obtaining biopsies initially and at time of progression and using standard and novel blood tests. The consistency of results between expanded panel (TSO500) based testing of tumour tissue and laboratory-based profiling of the matched PDTO will be examined. It is hoped that these results will help improve decision making by clinicians and ultimately individualise patient's treatment to improve outcomes. Patients will receive standard of care treatment at the discretion of their Oncologist. (this is standard practise, done for those not participating in clinical trials also). It is hoped that findings from this study will establish reliable preclinical models that will enable high throughput drug testing to guide optimal treatment selection in daily clinical practice in the future, and potentially inform treatment selection of standard of care agents in first and later line treatment.

Population: Women giving birth to Aboriginal children participating in the Aboriginal Family Birthing Program (AFBP) at the Women’s and Children’s Hospital (WCH), Adelaide and through Child and Family Health Centres (CaFHS), SA. Study design: Mixed methods: qualitative (consultations with young Aboriginal women, community members and service providers), and continuous quality improvement (Plan-Do-Study-Act (PDSA) cycles) involving nutritional support and health literacy. Interventions: Culturally appropriate, intensive multifaceted intervention strategy to promote healthy eating embedded in SA AFBP/CaFHS, centering around 9 ‘mother and baby bundles’ given to participating families by Aboriginal Maternal and Infant care workers and CaFHS staff at key points in pregnancy and the first 12 months postpartum, refined through PDSA cycles. Comparisons: Routine data from past AFBP clients and their babies. Outcomes: Increase in proportion of women with healthy gestational weight gain and healthy postpartum weight, improved dietary changes (e.g. increased vegetable consumption), increased engagement and satisfaction with the program, improved nutritional status, higher rates of breastfeeding and improved infant health and growth. Significance: This intervention strategy will identify effective and sustainable ways to engage young women (and partners/children) in making healthy food choices, in managing weight, and in reducing obesity and associated short, long-term and intergenerational issues.

We developed an eHealth solution – Music Attuned Technology for Care via eHealth (MATCH) – to support carers of PwD to use music intentionally to support care. The mobile application was developed as an extension of an in-person music intervention training program (HOMESIDE - ACTRN12618001799246) which involved a qualified music therapist offering one on one training to carers in the intentional use of music. In this feasibility study (Study 4), we will: a) evaluate the adherence, usability, and acceptability of MATCH for PwD and their CGs community setting. b) explore the clinical and health economic impact associated with engagement with the MATCH solution, especially on agitation, quality of life, and care burden. c) explore adherence, usability, and acceptability of MATCH for PwD and their CGs during the transition between community setting and RAC.

This study aims to examine the impact of a naturally occurring polyphenol extracted from tea on blood uric acid levels in healthy adults. Researchers will administer the polyphenol to participants and monitor changes in their uric acid concentrations for 6 weeks treatment. The goal is to determine if this tea-derived compound can effectively lower uric acid levels. The study will provide valuable insights into the potential health benefits of tea polyphenols.

Unhealthy dietary patterns including high intakes of sodium, refined carbohydrates, processed and red meat, and low intakes of fruits, vegetables, wholegrains, nuts and legumes, and fibre are leading risk factors for noncommunicable diseases such as type 2 diabetes. Eating a healthy diet is fundamental to the management of type 2 diabetes, but this can be particularly challenging for those who struggle with food security. Current clinical practice based on providing dietary counselling alone is inadequate if individuals are unable to access and prepare the foods and meals recommended. ‘Food is Medicine’ programs aim to integrate nutrition interventions into the health care system to help improve the clinical population’s diet and complement pharmacologic treatment of diseases. ‘Produce prescription’ (Produce Rx) is one such approach, in which healthy foods are subsidised or provided free-of-charge to patients as part of a health care intervention. We will therefore conduct a randomised controlled trial of produce prescription in adults with type 2 diabetes (T2D) and ongoing hyperglycaemia who experience food insecurity, recruited from diabetes centres in large hospitals and General Practices (GP) in New South Wales, Australia, and through a community advertisement. As part of the intervention package, participants will receive produce prescription (a healthy food box delivered to their homes) and be provided with dietary consultations to encourage uptake of foods and support enhancement of the overall healthiness of their diets. Our goal is to investigate a real-world pragmatic produce prescription intervention that will be feasible to embed in the Australian healthcare system. We are testing a primary null hypothesis of no difference in the HbA1c between participants in the intervention (receiving produce prescription) and control group (usual care) over 26 weeks.

The aim of this study is to compare the benefits and limitations of different positioning options for early breast cancer patients who are suitable for partial breast treatment on the Magnetic Resonance integrated Linac. Who is it for? You may be eligible for this study if you are a female age 40 or older, with early stage breast cancer and suitable for accelerated partial breast radiotherapy. Study details Participants will receive both a supine (on your back) and prone (on your tummy) scan in the MRI and a CT scan in the ideal treatment position (supine OR prone) as per our usual standard of care. Participants will then be asked to complete a short (10-15 mins) anonymous survey on an electronic platform to ask about their experience of the MRI scan and whether they have a preference for the supine or prone position. There are no changes to standard treatments for participants. It is hoped that the findings from this study will streamline the simulation process for APBI patients and help us to determine who would benefit from which position without needing to complete both scans. It is also hoped that this information can be used across our other treatment machines to benefit patients who may not be able to have an MRI scan to work out the best position for them.

The treatment of inflammatory bowel disease (IBD) primarily involves targeting inflammation with pharmacological agents, but comorbidities, including functional gut symptoms (DGBI), are common and poorly defined within this population. DGBI diagnosis in IBD is challenging due to confounding factors and reliance on symptom-based criteria. Current assessment methods, such as clinical remission evaluation and biochemical markers, may not accurately identify DGBI in the absence of inflammation. Advances in assessment include intestinal ultrasound for detecting ongoing disease activity and identifying patients with increased intestinal permeability, potentially aiding in distinguishing functional gut symptoms from inflammation-associated symptoms. Limited evidence exists for efficacious treatments for DGBI in IBD, with a notable exception being a trial supporting the use of a low FODMAP diet for symptom relief in patients with quiescent disease. Gut-directed hypnotherapy (GDH) emerges as a potential therapy to reduce symptom burden, offering efficacy comparable to in-person sessions and superior to psychoeducation. However, research on GDH efficacy specifically in patients with truly quiescent IBD is still ongoing.

MATCH is an eHealth solution, “Music Attuned Technology Care via eHealth,” developed to support carers of people living with dementia to use music intentionally to support care. It is a scalable solution for the growing number of people living with dementia. We developed the ‘MATCH Music Training Program’ as part of this package, which we will trial 2 MATCH interventions in residential aged facilities in this feasibility study to inform future powered trials.

The purpose of this study is to ascertain whether more extensive ablation for Atrial Fibrillation is more effective than limited ablation. We hypothesise that more extensive ablation will be more effective.