ANZCTR search results

This study will conduct a randomised controlled trial to evaluate the feasibility, acceptability, and preliminary efficacy of the program to reduce suicidality, depressive symptoms, and improve quality of life, among trans people on a waitlist for initiating GAHT. Participants in the intervention condition will attend 7 x 1.5hr weekly sessions of the peer support program over seven weeks, co-facilitated by two trans people. Participants in the control group will remain on the standard care waitlist and will not receive the intervention. Participants in both groups will be required to complete 3 x 20min online health surveys. If proven feasible, acceptable, with preliminary evidence of efficacy, this program may represent an implementation-ready and readily scalable solution to address the mental health support needs of trans people on GAHT waitlists across Australia.

This study aims to determine the tolerability, safety and efficacy of fibre supplementation to reduce side effect symptom severity and promote maintenance therapy adherence in people with breast cancer Who is it for? You may be eligible to join this study if you are aged 18 years or older, currently receiving systemic maintenance therapy (including chemotherapy, endocrine therapy and/or targeted therapy) for breast cancer, at 6 to 18 months following initial diagnosis, experience side effects to your maintenance therapy and are able to provide informed consent to all trial related procedures. Study details All participants who meet the eligibility criteria in this study will be randomised to either the intervention or control group. In the intervention group, all participants will be provided with a fibre supplement daily for 3 months, whilst on maintenance therapy for breast cancer. The control will continue with their current maintenance therapy and standard care. They will be offered the fibre supplement 1 month after the intervention has been completed. During and post intervention, participants will be assessed for side effects, dose modification, adverse events, gut microbiota, and brain structure. It is hoped that this research project will provide the first evidence supporting the beneficial role of fibre in reducing breast cancer treatment side effects, informing larger scale trials to produce the knowledge required for clinical implementation of fibre as a supportive cancer care strategy.

The study is designed to reflect a real-world scenario where an exercise physiologist may deliver small group breathwork sessions online whilst providing participants materials to perform self-directed practice at home. Additionally, the study will begin the process of developing protocols for safe and effective telehealth breathwork sessions. This includes screening, orientating participants to the telehealth environment, providing technical support, setting online group class etiquette and structure, optimising the home practice environment, promoting social engagement support, and providing opportunities for feedback. The research will be used to inform future studies

This project aims to embed a new technologically based approach for the screening of delirium into the Emergency Department with the goal of improving accuracy and timeliness of diagnosis of delirium in all patients presenting to ED over 65 years of age. The new tool, named DREAM, will be used in parallel to the current clinical screening standard, 4AT, and a diagnostic "gold standard" diagnosis in 100 patients above the age of 65 presenting to ED. Order of testing will be randomly assigned and prospective consent will be obtained from all participants or their primary decision makers. The primary study outcome is diagnostic accuracy of DREAM, which will subsequently lead to implementation into clinical practice. This implementation will provide future opportunities to combine DREAM with existing, electronic delirium aetiology tools to enhance clinical decision support for delirium diagnosis. Early and accurate diagnosis and treatment will significantly improve patient outcomes, such as shorter hospital length of stay, fewer re-hospitalisation, and reduced morbidity and mortality.

The Holding Hands Program is a parenting program designed to assist parents and carers of young children who are having difficulty parenting. It draws on recent research and treatment evidence about the importance of parent-child relationships and parent emotion regulation for child development. The trial will be delivered at the UTS Family Child Behaviour Clinic within the Graduate School of Health at UTS. The Holding Hands Program will be delivered by provisionally registered UTS Master of Clinical Psychology students in their final year of training. The study will use a within groups design to compare the outcome of treatment as usual with the outcomes from The Holding Hands Program. It is hypothesised that treatment gains will be demonstrated post intervention and at follow-up, and will include statistically and clinically significant change in child and parent functioning. Everyone working on the trial will hold a current NSW Working With Children Check..

Migraine is a significant problem that predominantly affects young women. Hormonal changes associated with menstruation can be a trigger for migraine flares. We are investigating the use of a combined estrogen/progesterone contraceptive pill to see whether it is safe, well-tolerated and effective in treating the symptoms of menstrually-related migraine.

This study explored whether a single-session online Mindfulness-Based Art Therapy Doodling Intervention could support the wellbeing of school teachers in regional Victoria. The two-hour workshop guided participants through mindfulness and creative doodling activities designed to enhance self-awareness, self-compassion, and classroom confidence. The purpose was to evaluate whether this simple, accessible approach could help prevent burnout and strengthen internal coping resources. We hypothesized that teachers would show improvements in mindfulness, self-compassion, and teaching self-efficacy after participating in the session.

This is a Phase 1, open-label, 4-period, period-balanced trial in healthy participants. The trial will investigate the relative bioavailability of 2 formulations (IR tablet and minitablet) of JNT-517 along with the effect of food on the pharmacokinetics of JNT-517. All participants will receive a single dose in a fasted or fed (high fat meal) state.

This study aims to investigate how different amounts of eccentric lunge walking affect physical fitness, muscle strength, balance, mental health, and overall quality of life in adults aged 60 to 80 who are less physically active. We believe that participants who do a higher dose of this exercise will show greater improvements in these health areas compared to those who do a lower dose.

The problem – inpatient harm. Preventable adverse events in Australia’s hospitals are a major safety issue. The magnitude of preventable adverse events coupled with failure to escalate care of deteriorating patients provides strong evidence that existing nursing assessment and management frameworks are not fit-for-purpose. Research is needed to inform the development of an intervention to enhance nursing practice to (a) prevent adverse events, (b) optimise patient experience and (c) improve clinical communication. The aim of this project is to design, implement and evaluate the effect of HIRAID® Inpatient on patient, staff and health service outcomes.HIRAID® Inpatient will be an adaptation of our validated and highly successful emergency nursing framework – HIRAID® (History including Infection risk, Red flags, Assessment, Interventions, Diagnostics, reassessment, and communication).