ANZCTR search results

Through a co-design study we have designed an online Prescription Opioid Safety Toolkit to increase consumers knowledge about opioid pain medicines and safety relating to their use. This study will test if the effect of the Toolkit on opioid safety knowledge and behaviours, and the acceptability of the Toolkit prior to a planned national dissemination campaign.

The purpose of this trial is to assess the feasibility of a novel eye heating device for the treatment of meibomian gland dysfunction in adults with the condition compared to a commercially available heating eye mask. Various ocular observations and questionnaires will be used to assess the feasilbility.

This prospective randomised controlled trial, employing a split-mouth design, aims to investigate the impact of low-level laser therapy (LLLT) on root resorption in first premolars subjected to bite-raising forces. Conducted at the Department of Orthodontics at Sydney Dental Hospital, the study will recruit participants requiring extraction of all four first premolars for orthodontic treatment. One side of the mouth will receive a sham laser while the contralateral side will be treated with LLLT. Pain experiences will be evaluated using a Visual Analogue Scale, and pulp vitality will be tested throughout the 28-day study period. Post-extraction, micro-computed tomography will be utilised to measure the surface volume of resorption. This approach aims to provide quantitative insights into the effects of LLLT on root resorption and cemental repair, offering potential implications for orthodontic treatments.

This prospective randomised controlled trial, employing a split-mouth design, aims to investigate the impact of low-level laser therapy (LLLT) on the repair of root resorption in first premolars subjected to bite-raising forces. Conducted at the Department of Orthodontics at Sydney Dental Hospital, the study will recruit participants requiring extraction of all four first premolars for orthodontic treatment. One side of the mouth will receive a sham laser while the contralateral side will be treated with LLLT. Pain experiences will be evaluated using a Visual Analogue Scale, and pulp vitality will be tested throughout the laser therapy. Post-extraction, micro-computed tomography will be utilised to measure the surface volume of resorption. This approach aims to provide quantitative insights into the effects of LLLT on root resorption and cemental repair, offering potential implications for orthodontic treatments.

The aim of this study is to compare the efficacy of 200ml and 400ml bottles used in nasal saline irrigation by conducting a randomised controlled trial in post-Functional Endoscopic Sinus Surgery (FESS) patients.

Our objective is to find out if our planned series of five weekly online interactive workshops, called ENVISAGE - Service Providers (ENVISAGE-SP), is helpful to service providers’ practice, and supports service providers to empower families who have a child with neurodevelopment disability (NDD) to take a strengths-based approach to their child’s and family’s issues. We will recruit 80 service providers working with children with developmental challenges and their families in Australia or Canada. Conduct an open mixed-methods before-after pilot evaluation (data collected at 5 time-points – baseline, completion, and 3, 6, 12 months post-completion) to: (i) Evaluate (quantitatively) the impact of the ENVISAGE-SP program on SPs. (ii) Explore (qualitatively) SPs’ perceptions and experiences of the program (i.e., satisfaction, challenges), as well as the extent to which SPs feel the program has influenced their thinking (i.e., knowledge/attitudes) and activities (i.e., professional behaviours). (iii) Evaluate (quantitatively and qualitatively) implementation outcomes (i.e., acceptability, feasibility, adoption).

Intraoperative cell salvage (ICS) is increasingly accepted as a safe alternative to allogeneic (donated) blood transfusion (ABT) with the potential to reduce ABT related adverse outcomes and improve immune competence. Remaining obstacles include: 1) the risk of systemic bacteraemia in the presence of bacterial contamination from the surgical field and 2) the potential risk of systemic cancer cell dissemination during surgery for malignant tumours. When considering these specific obstacles (i.e., cancer and bacterial contamination risks), pelvic exenteration surgery is of particular clinical interest. These procedures aim to cure patients with locally advanced adenocarcinoma. Major blood loss, requiring massive blood transfusion, often occur. However, considering the nature of the surgical field, potentially contaminated with cancer cells and bacteria (from bowel content), ICS is not used. The C-I-ICS study, aims to assess whether ICS (processing and filtering) could reduce the risks of cancer cell and bacterial dissemination, into the patient’s circulation, when used during curative pelvic exenteration surgery.

The main aim of this research is to test the feasibility of a six-week combined exercise and nutrition intervention delivered to endometrial cancer patients before surgery. Who is it for? You may be eligible for this study if you are aged 18 years or older, you have been diagnosed with early stage endometrial cancer and you have an identified surgical risk factor including being overweight, having high blood pressure and/or high cholesterol, and/or type 2 diabetes. Study details All participants who choose to enrol in this study will be prescribed an exercise regime to follow for 6 weeks prior to their scheduled surgery to remove their cancer. The exercise regime will involve one weekly session with an exercise physiologist and two sessions at home, as well as a target level of exercise to complete each day, which may include walking/running, cycling or swimming. Participants will also be given options to follow a diet plan for six weeks prior to their surgery or to use Optifast products as meal replacements if it is safe for them to do so. It is hoped this research will provide important information to help endometrial cancer patients better tolerate the physical challenges of surgery and enhance their post-surgery recovery. If this study shows positive effects on post-surgery recovery, a larger trial enrolling a greater number of participants may be undertaken in the future.

This project is designed to investigate the impact of a social humanoid robot to deliver a low-intensity program about improving physical activity. It is intended that this trial will focus on how a robot can help people to increase their physical activity. This will include finding how the relationship the participant has with the robot will act to create variable outcomes in physical activity.

This study is a randomised controlled trial investigating the effectiveness of refeeding strategies post-competition in natural physique athletes. Athletes will be measured at baseline before beginning their competition preparation phase that typically lasts between 20-25 weeks. Following competition, they will be randomly allocated into one of the following nutrition strategies; ARM-1 Ad Libitum or ARM-2 Dietitian Intervention, to follow for 12 weeks post-competition. Primary outcomes assessed will included changes in metabolic rate and body composition. Investigators hypothesize that individualised dietetics intervention will result in faster recovery of physiological markers post-competition.