ANZCTR search results

This study aims to evaluate the feasibility of a mediterranean meal box for people living with Parkinson's disease and their family. It is hypothesised that the meal box will be safe and practical for individuals with Parkinson's disease and their family to use. Furthermore, it is expected that it will promote healthy cooking and eating behaviours and better quality of life.

Polysomnography (PSG) remains as the gold standard for diagnosing sleep-disordered breathing in children as it provides comprehensive monitoring of cardiac, respiratory, musculoskeletal, and neurological functions. However, the procedure’s requirement for overnight hospital stays and skilled personnel poses significant challenges including long wait times, high costs and difficulties in reflecting daily sleep patterns due to the unnatural sleeping environment. Alternatives like smartphone videos and overnight oximetry, though more accessible, lack diagnostic accuracy. This study aims to address these limitations, by introducing a minimally invasive on-mattress device capable of recording body position, acoustic, respiratory and cardiac signals, with oximetry data (via a pulse oximeter) to identify breathing issues during sleep. We hypothesise that this device will simplify and improve the diagnosis of sleep-disordered breathing in children.

Polysomnography (PSG) currently remains the gold standard for diagnosing sleep-disordered breathing in children as it provides comprehensive monitoring of cardiac, respiratory, musculoskeletal, and neurological functions during sleep. However, paediatric PSG requires a 1-night in hospital stay with extensive instrumentation with multiple wires and sensors setup and monitored by skilled personnel. This process poses significant challenges that include long wait times, child and parental distress from the procedures and unnatural sleeping environment, high costs and problems of extrapolating 1-night PSG results to usual sleep at home. Alternatives like smartphone videos and overnight oximetry, though more accessible, lack diagnostic sensitivity, specificity and accuracy. This study aims to address these limitations by introducing a minimally intrusive on-mattress device capable of recording body position, acoustic, respiratory and cardiac signals, along with oximetry data (via a pulse oximeter) to identify breathing issues during sleep in the normal home sleeping environment. Following successful proof-of-concept trials in adults, this study seeks to pilot test the use of this device in children to assess potential clinical utility, feasibility and reliability compared to PSG and overnight oximetry in paediatric sleep medicine care.

The purpose of this study is to determine whether the Growing Screw is a preferable or non-preferable screw compared to the traditional screw in the treatment of Slipped Capital Femoral Epiphysis. Patients will be randomly allocated to each group and will receive the screw through a single surgical procedure. They will then be closely followed-up and information about the two screws will be gathered and statistically compared to determine which is better for long term hip function and pain.

In this study, we are evaluating the effectiveness of a sexual violence prevention program called CaRE (Consent and Relationship Education), designed for university students living in student accommodation. The program aims to improve students’ knowledge, attitudes, and behaviours related to consent and sexual violence. There are three groups in the study: one group will receive four CaRE sessions, another group will do a shorter version with three sessions, and the third group will not receive the program during the study but will have the chance to do the program later. By comparing outcomes across these groups, we aim to understand the impact of the CaRE program and whether the full or shorter version produces stronger outcomes. We anticipate that students who participate in the program will show increased knowledge of sexual violence, improved confidence and skills in negotiating consent and respectful relationships, and reduced endorsement of harmful attitudes and behaviours.

This study aims to investigate the effects of a 4-week Expiratory Muscle Strength Training (EMST) program on speech and swallowing in people with Parkinson’s disease (PD) who have undergone Deep Brain Stimulation to the subthalamic nucleus (STN-DBS). While EMST has shown benefits in PD populations, its impact following STN-DBS has not yet been explored. Twenty-four eligible participants will complete pre- and post-intervention testing, with home-based EMST sessions conducted five times per week. Outcome measures will include speech, voice, and swallowing assessments, alongside quality of life and cognitive screening. Results will be analysed using linear mixed models to evaluate the effectiveness of EMST in improving communication-related outcomes in this population.

Community-based dance programs may offer multiple benefits for Autistic children, including improvements in motor, social, and cognitive functioning. However, rigorous empirical research, particularly randomised controlled trials, evaluating these benefits remains limited. This randomised controlled trial (RCT) aims to assess whether participation in the community-based dance program, AllPlay Dance, improves children’s movement abilities, social functioning, thinking skills, emotional and behavioural functioning, as well parental stress compared to a treatment-as-usual waitlist control condition, from pre- to post-intervention. Additionally, we will assess the acceptability and feasibility of the AllPlay Dance program post-intervention for families and buddies, as well as whether families continue participating in community-based dance programs and how they describe their experiences at follow-up.

Durable left ventricular assist device (LVAD) is a form of mechanical support used in patients with end-stage heart failure as a bridge to heart transplantation. The technical challenges in heart transplantation in patients with an LVAD are often associated with adhesions around the heart and great vessels. Coseal is a commercially available product which forms a hydrogel that inhibits adhesion formation. This study aims to investigate the effect of Coseal spray application at the time of LVAD implant on the adhesions that are encountered at the time of OHTx.

Middle meningeal artery is an important part of the trigeminovascular system and may be important in migraine pathophysiology. By blocking blood flow to this artery migraine headaches may be reduced in frequency or severity.

The safety and levels of PTC844 tablets administered under fasted and 2 fed conditions (standard meal and high-fat meal) will be assessed in an open label (no blinding), 2 arm, single fixed sequence, and 2 period cross-over design with each arm in healthy participants.