ANZCTR search results

The primary objective of this study is to investigate the acute effects of dietary flavonoids (quercetin) and nitrate on blood pressure, endothelial function and nitric oxide (NO) status in men and women.

Main study (study 1): This study evaluates the effectiveness of an online decision aid for women considering breast reconstruction following mastectomy. Who is it for? You can join this study if you are a woman over 18 years who: - Has recently been diagnosed with breast cancer - Is a candidate for mastectomy and breast reconstruction - Has basic computer skills and access to an online computer Trial details: Participants will be randomly divided into two groups. Participants in both groups will receive standard care which involves the provision of basic information about breast surgery and options for surgery. Participants in one group will also have access to an online decision aid tool, Breconda, to assist in their decision making. The aim of this study is to determine the effectiveness of the online decision aid tool in helping women make a decision they are happy with according to a scale that measures decisional conflict and regret scales. Genetic study (study 2): This study evaluates the effectiveness of an online decision aid for women at increased risk for hereditary breast cancer. Who is it for? You can join this study if you are a woman over 18 years who: - Is undergoing genetic testing for hereditary breast cancer - Is a possible candidate for risk-reducing mastectomy and breast reconstruction - Has basic computer skills and access to an online computer Trial details: Participants will be randomly divided into two groups. Participants in both groups will receive standard care which involves the provision of basic information about breast surgery and options for surgery. Participants in one group will also have access to an online decision aid tool, Breconda, to assist in their decision making. The aim of this study is to determine the effectiveness of the online decision aid tool in helping women make a decision they are happy with according to a scale that measures decisional conflict and regret scales.

Randomised trial to assess the impact of intercessory prayer on spritual wellbeing od patients presenting wioth cancer to the Royal Adelaide Hospital Cancer Centre

Children with the more severe forms of cerebral palsy often have difficulties with pain or discomfort associated with spasticity. Spasticity can also impact upon the burden of care parents experience. Botulinum toxin A has been used for over a decade in the treatment of spasticity for children with cerebral palsy however most research to date has focussed on functional gains for children with the less severe forms of cerebral palsy. this study hypothesises that botulinum toxin A injections when combined with a therapy program improves outcomes of burden of care and comfort for children with severe cerebral palsy when compared to a therapy program alone.

This study aims to evaluate the overall usefulness of 3-point compression ultrasonosgraphy performed by emergency physicians in the emergency department for the diagnosis of proximal lower-extremity deep venous thrombosis. In order to be useful, the examination should be accurate, fast, technically adequate and easy to learn. Therefore, this study will examine the accuracy, rapidity and technical adequacy of the examination, as well as the learning curve emergency physicians experiencing with the examination. We hypothesise that the examination will be useful.

This is a descriptive study of a group of 15 women to comment on the possibility of an association between changes in menopausal symptoms following the use of a complementary therapy. Participants will have good general health and demonstrate a recorded minimum of 21 hot flushes per week and above 80% compliance during placebo run in. They will self administer 2 placebo tablets twice daily over the 28 day run in period and two tablets of Zen Harmony twice daily over 12 weeks of active treatment. Participants will be supplied with a daily diary containing a record of vasomotor symptoms (flushing) and instructed how to complete the required data. They will also complete the Greene Climacteric Scale, the Women's Health questionnaire and the Menopause rating scale at each clinic visit. .

The aim of this proposed study is to find out whether the use of interactive electronic nutrition and parenting resources will provide parents with the skills and knowledge required to change their child feeding practices. This will result in children aged 2 – 5 years (whose parents are part of the study) increasing vegetable consumption and decreasing consumption of sweetened drinks and foods that are high in fat, salt or sugar when compared to the control group who are provided with traditional written nutrition education resources that are targeted at the same key nutrition messages.

The trochanteric bursa is an anatomic element, which is usually divided during the commonly used posterolateral hip approaches in Total Hip Arthroplasty. So far, very little attention has been paid in the role of its preservation in major hip surgical interventions. Some surgeons prefer to simply resect the bursa as they believe that may be responsible for lateral thigh pain. Other surgeons advocate that preservation of the tissue may add a “protection” layer to the hip joint. The purpose of the study is to compare the clinical results of either resecting or repairing the trochanteric bursa after Total Hip Arthroplasty. Therefore, the tissue will be resected in half of patients and repaired in the other half. The patients will be evaluated in terms of lateral thigh pain and hip mobility. A comparison will be made in each group between the preoperative period and serial time points at the postoperative period. The two groups will be also compared each other.

An elbow brace is commonly used by patients to help manage the pain of tennis elbow, however good quality evidence to support the use of braces in the management of tennis elbow is scarce and the evidence is conflicting. The aim of this study is to compare the immediate effects of two tennis elbow braces; the ‘Go-Strap’ brace and a standard counterforce brace, in people with tennis elbow. It is hypothesised that the 'Go-Strap' brace will reduce pain and increase function significantly more than either the counterforce brace or a control (no treatment).

High frequency mechanical strain, as delivered when standing on a whole body vibration (WBV) platform, has been shown to have beneficial effects on weight bearing bone and muscle mass. Improved bone health in older adults from the use of gently vibrating platforms may be possible, but more scientific investigations are required. The role of these devices is poorly understood. This study proposes to investigate the effect of six months of WBV training on BMD, bone geometry and muscle mass and function in older adults; and to examine the dose-response relationship between optimum vibration protocols and bone mineral, bone geometry and muscle mass. The study will be a randomized controlled trial. The primary outcome measures will be BMD and muscle mass measured with dual energy X-ray absorptiometry (DEXA) and bone geometry and muscle area of lower limbs measured using peripheral quantitative computer tomography (pQCT).