ANZCTR search results

Study Rationale: The current choice of treatment for intertrochanteric fracture is the Dynamic Hip Screw. Technical and mechanical failure of this device currently occurs in 6-18% of all cases. Better understanding, more validated data and the need for better treatment regarding intertrochanteric fracture is necessary. "Prospective studies comparing the trochanteric nail, with and without distal interlocking to the sliding/dynamic hip screw are warranted". Study Aim: The purpose of this prospective randomised study is to compare the intramedullary gamma nail to the dynamic hip screw in regards to functional outcome. Specific Aims: The aim of this study is to compare the results of the surgical intervention with parameters such as operative time, blood loss, operative complications and cost for each device. In the post operative period the functional results of patients will be compared with initial mobilisation and discharge through to long term function and return to activities of daily living. The degree of fracture collapse will be recorded and compared to function. Long term fracture union will also be assessed.

The project aims to demonstrate that transversus abdominis plane block is an effective adjunct to multi-modal analgesia in the setting of major gynaecological surgery via midline laparotomy. The project aims to demonstrate that the technique improves overall pain relief, reduces morphine consumption (and opioid side effects) and improves patient satisfaction.

This is a study of an experimental anti-cancer drug called CYT997, which targets the blood supply of the tumour. In this study, CYT997 is given as a 24 hour intravenous (IV) infusion on day 2 of a 21 day treatment cycle over 3 cycles. In this study, CYT997 is given in combination with another commonly used standard chemotherapy drug called Carboplatin. You may be eligible to join this study if you have Relapsed Glioblastoma Multiforme and a life expectancy of more than two months. Most advanced cancers will eventually stop responding to cancer treatments. In this situation, for people who may be eligible for this drug trial, there may not be any alternative standard treatments. Participants will receive supportive care and symptomatic treatments during the trial, in addition to receiving CYT997 and Carboplatin. The major focus of this trial is to test the safety, tolerability and effectiveness of CYT997 when given in combination with Carboplatin in patients with Relapsed Glioblastoma Multiforme. This involves finding out the highest dose of CYT997 that can be given without causing severe side effects. The trial also aims to assess the effects (good and bad) that CYT997 may have on you and your cancer.

Patients admitted to RGH for a lower-limb amputation will be invited to participate in a study investigating the effect of a diet that is enriched with arginine on the time taken for the amputation wound to heal, and the time taken to have a prosthetic limb fitted. Participants will be allocated at random to receive either a standard hospital diet with 2 Arginine-enriched supplements or a standard hospital diet with 2 standard nutritional supplements, that are equal in energy, protein, vitamins and minerals. In addition to the time taken for the wound to heal, participants will also have their nutritional health measured via body weight, dietary intake and arm muscle stores. Quality of life will also be measured.

People with severe curvature of the spine (kyphoscoliosis) have a reduced exercise capacity and are often limited by their respiratory system. The aim of this study was to determine the effect of low level and high level breathing support (provided via a mask) during treadmill walking in people with severe curvature of the spine (kyphoscoliosis) compared to sham breathing support and walking unassisted. We hypothesised that only high level breathing support would increase exercise endurance time in people with severe kyphoscoliosis.

The risk of cancer, including colorectal cancer is increased in recipients of kidney transplants. This study is designed to evaluate the standard population screening tools for colorectal cancer, ie faecal occult blood testing and colonoscopy, in this high risk population. All recruited patients will undergo both of these screening tests, and from this we will investigate the rates of colorectal cancer and pre-cancerous growths in this population, and the usefulness of the two screening tests for this group of patients.

This research program will test the hypotheses that removing caffeine from soft drinks will significantly decrease liking of and energy intake from these products and that this reduction in energy intake is sufficient to reduce average body weight in the Australian population. This project has two key aims: 1. To determine if the removal of caffeine from soft drinks results in a decreased consumption of these beverages. 2. To use these results to model the effect of caffeine removal from soft drinks on total energy intake and body weight of the Australian Population.