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Gestational diabetes is a problem in pregnancy that can be diagnosed in up to 10% of pregnant women. The majority of patients are managed with dietary advice and lifestyle measures alone. Dietary advice consists of education and meal planning addressing issues of caloric intake, content (fat & carbohydrate) and timing of meals. Lifestyle measures revolve around suitable exercise and energy expenditure. Gestational diabetics monitor their blood glucose levels (BGL). This project collects data on energy expenditure through daily physical activity from pregnant women wearing a portable Energy Monitor, developed in our research group. There is no radiation associated with this monitor. Together with a record of food intake this study seeks to evaluate whether it is possible to calculate a differential between energy intake and energy expenditure that correlates with measures of glycaemic control (average daily BGLs), infant weight and maternal weight gain.

The purpose of this clinical study is to assess the safety and ease of use of the Osprey Medical Contrast Induced Nephropathy System in contrast retrieval during/after diagnostic or interventional percutaneous coronary procedure

This parallel double-blinded and randomised placebo controlled study examined effects of He Shou Wu Capsule (HSWC), a pharmaceutical preparation derived principally from the Chinese herbs Radix Polygoni Multiflori, Radix Salviae Miltiorrhizae, on a range of cardiovascular disease risk factors in subjects with mild to moderate hypercholesterolemia.

A parallel double blind randomised placebo-controlled study was conducted to assess the effects of a Chinese herbal medicine, the Dantonic Pill, on circulating adhesion molecules in participants with mild-moderate hypercholesterolemia.

This study will examine the links between bone structure and metabolism, type 2 diabetes (T2DM) and exercise. First, we aim to test the hypothesis that bone is implicated in the pathogenesis of T2DM through mechanisms involving osteocalcin (OC) in its uncarboxylated (unc-OC) form. Second, we aim to examine the acute and chronic effects of a novel form of exercise training for people with T2DM, power training, and compare it to aerobic training on osteocalcin-mediated effects on glucose metabolism in females with and without T2DM. Hypotheses Phase One: Bone structural abnormalities are present in patients with T2DM, compared to non-diabetic individuals matched for aged, body mass index (BMI), although bone mineral density (BMD) is high. Phase 2: Acute effects of exercise: In both non-diabetic females and those with T2DM, power exercise will result in greater increases in unc-OC and high molecular weight (HMW)-adiponectin (AN) levels, compared to the acute effects of aerobic exercise. Phase 3 Chronic effects of exercise: In both non-diabetic females and those with T2DM, power training will result in greater improvements in bone structural strength and a shift of bone remodelling balance towards greater formation than for aerobic exercise training.

This study is designed to investigate modafinil’s efficacy to improve parameters of daytime sleepiness and neurocognitive ability in untreated patients with mild to moderate OSA.

The aim of the project is to determine whether the benefit of flat-ground walking training is similar to cycling training in improving exercise capacity and health related quality of life (HRQoL) in patients with chronic obstructive pulmonary disease (COPD). Hypothesis: On completion of an eight-week training program, subjects with COPD will demonstrate similar improvement in exercise capacity and HRQoL in the flat-ground walking training group and the cycling grop.

In patients with type 2 diabetes, it is proven that good glucose control during stressful events like after surgery and after a heart attack helps improve the outcome. Therefore in patients with type 2 diabetes requiring insulin and undergoing stressful events, real-time continuous glucose monitoring which provides detailed information on the glucose trends may improve glucose control compared with intermittant glucose monitoring with finger pricks shich are "snap shots" of the ever fluctuating glucose level.

Several formulations have been used for IDPN and have ranged from those with minimal provision of nutrients to those that deliver significant amounts of calories and amino acids. Administration of lipid was originally considered to be contraindicated in IDPN but studies suggest otherwise and lipids are now used routinely. Austin Health is the first dialysis centre in the world to use standard lipid only IDPN solution. Since then a 20% lipid 500 ml or 30% lipid 250 ml solutions are routinely used in our haemodialysis patients requiring IDPN support. What effect if any is this practice having? Would the use of a more standardised practice of protein, lipid and dextrose combined solution be more beneficial?

To investigate if nebulised heparin improves oxygenation of patients with acute lung injury