ANZCTR search results

The Australian Mepolizumab Registry (AMR) collects data on individuals with severe refractory asthma who receive mepolizumab for the management of their asthma. This includes those with treatment-resistant severe eosinophilic asthma who receive Pharmaceutical Benefit Scheme (PBS)-subsidised mepolizumab, and those with treatment-resistant severe asthma who receive mepolizumab outside of the PBS scheme. The AMR provide a mechanism for researchers and clinicians to better understand the use, effectiveness, and safety associated with the treatment of severe asthma with mepolizumab.

The purpose of this randomised intervention study will be to see if the amount of sunscreen applied to young children will improve with novel interventions, involving either daily personalised text messages or the daily use of stickers that change colour when sunscreen needs to be reapplied. This study will also look at the beliefs and attitudes relating to the use of sunscreen and other sun protective behaviours in young children. In addition, the study will also look at barriers to the use of sunscreen and other sun protective behaviours in young children and will measure the amount of photoaging at the commencement of the study. The study will involve online baseline questionnaire with the 1st visit to IHBI (Institute of Health and Biomedical Innovation) at QUT Kelvin Grove, Brisbane, Queensland, Australia. Followed up one week later by an online follow up questionnaire with a 2nd visit to IHBI. Followed up by a final online follow up questionnaire 3 months after the baseline.. Randomised into Control Group (participant takes tube of sunscreen home to use as usual), Intervention Group 1: Personalised Text Group (participant takes tube of sunscreen home to use AND receives personalised text message intervention each morning) or Intervention Group 2: Suncayr Stickers Group (participant takes tube of sunscreen home to use AND take Suncayr stickers to use).

Video-assisted Thorascopic Surgery (VATS) is a common painful surgical procedure for which there is no broadly acceptable choice of regional analgesia which is effective, safe and technically less demanding than neuraxial procedures. The erector spinae block is a novel interfascial plane block that has shown promise in case studies and anecdotally within our department. The purpose of this initial cohort trial is to assess the efficacy and safety of the erector spinae block as a means of peri-operative analgesia in patients undergoing VATS procedures.

This study aim is to assess the feasibility of implementing an e-health-supported intervention comprised of a tailored physical activity plan and a progressive resistance exercise program for people living in rural Australia with chronic non-specific low back pain (LBP) and/or knee osteoarthritis (OA) in comparison to usual care. Participants allocated to the e-health intervention group (n=78), will receive a tailored physical activity and progressive resistance exercise program delivered by remote health coach consultations. Usual care participants (n=78) will receive usual care. We hypothesise that the implementation of this e-health intervention will be feasible and demonstrate preliminary efficacy.

The underlying principle of trials evaluating the effectiveness of pharmacological treatments is to compare a drug against a placebo. The difference in effectiveness is then attributed to the active ingredient of the drug. Typically, placebos are designed to resemble the drug as much as possible, but conventional placebos that only contain lactose fibres do not elicit side effects and therefore do not fully resemble all features of the drug. The primary aim of this study is to evaluate if side effects increase the effectiveness of an otherwise inactive placebo treatment. We therefore developed an active placebo that will elicit side effects, but otherwise has no effect on sleep. We hypothesise that active placebos eliciting side effects demonstrate a larger placebo effect for sleep compared with conventional placebos that only contain lactose fibres.

The purpose of this study is to determine whether an online psychological intervention is feasible for women with advanced breast cancer. Who is it for? You may be eligible for this study if you are a female adult who has been diagnosed with advanced breast cancer. Study details Participants in this study will be randomly allocated to one of two groups: Group 1: Participants in this group will be provided with an online intervention consisting of 6 modules which focus on improving the psychological well-being and quality of life of women diagnosed with advanced breast cancer. Topics addressed by the modules include (1) Diagnosis and working with my medical team; (2) Managing physical symptoms (particularly fatigue and pain); (3) Managing emotional distress; (4) Managing identity and role-changes; (5) Social support: receiving support and supporting family; and (6) Living well with a progressing illness: Managing fear of progression and coping with uncertainty. Modules are released at a rate of one per week for six weeks, and participants will be able to access modules as much as needed during the intervention. Group 2: Participants in this group will receive a print-based resource provided by the Breast Cancer Network Australia. Participants in both groups will be followed up by researchers after completing the six week program, and asked to complete an online questionnaire assessing psychological well-being and quality of life. It is hoped that this research will help inform future, larger scale studies on the feasibility of an online intervention for women with advanced breast cancer.

Keeping a baby’s head and face uncovered during sleep is an important part of safe sleeping for babies to prevent Sudden Unexpected Death in Infancy (SUDI). It is also important to not to let babies become overheated while they sleep. Increasingly infant sleep bags are being used to keep babies sleeping safely. Sleeping babies in a safe baby sleeping bag, one designed especially for baby, with fitted neck and armholes and no hood, has a number of features that help baby sleep safely. Research has shown that sleeping bag use reduces the risk of bedclothes covering the baby’s face, and delays the baby rolling onto the tummy during sleep until baby is past the age of peak risk of SUDI. Supine sleep is also promoted when the zipper is opened to the front. In this study we will validate a new SmartSnugg infant sleeping bag which records and displays the temperature inside the sleeping bag so that parents can easily monitor this. Infants will be studied during sleep in two different thicknesses of SmartSnugg to assess if the SmartSnugg accurately records baby temperature. The company SmartSnugg are funding the Hudson Research Institute to conduct this study.

The purpose of this study is to assess whether a new combination of therapies, with stem cell transplant, will prolong remission and hold off recurrence of myeloma in patients who have been diagnosed with multiple myeloma and have not responded to standard treatment (currently Bortezomib). Who is it for? You may be eligible for this study if you are an adult who has been diagnosed with multiple myeloma and have had a minimal or no response to bortezomib based induction therapy. Study details If participants consent to take part in this study, they will receive the following: - Four cycles of daratumumab, lenalidomide and dexamethasone. These medications will be used to alter the immune system response to myeloma cells. - A transplant of their own, non-cancerous cells. - This will be followed 12 cycles of the same medications given initially (daratumumab, lenalidomide and dexamethasone) to ‘consolidate’ treatment. - After the completion of the 12 cycles, all participant will commence ‘maintenance’ phase of this study while involves daily doses of lenalidomide. Patients will also undergo routine blood assessments as per standard of care It is hoped that this treatment will provide an alternative treatment to those who have been diagnosed with multiple myeloma and have not responded to standard treatment.

:This study was initiated to clarify the confusing response to heparin and the difficulty in obtaining adequate heparinisation during catheter ablation for atrial fibrillation (CA-AF). The initial pilot study enabled a more rational approach to heparin management, and after recruiting 500 patients into the study, analysis is progressing with a view to demonstrating a method that enables: o accurate prediction of the heparin dose required to achieve an ACT with the desired range o maintenance of the ACT within the desired range during the procedure o a simple method for reversing the active heparin with protamine.

Daytime tooth clenching can cause broken teeth, headaches and face pain. This study is examining a way of managing awake bruxism by using a thin tooth cover to create awareness of the behaviour. Does this reduce tooth clenching and therefore reduce broken teeth, headache and face pain? Hypothesis: Wearing a thin tooth cover will create awareness of tooth clenching leading to a reduction in the behaviour and therefore a reduction in the effects of the behaviour.