ANZCTR search results

In patients who have both liver and kidney failure, average circuit life of continuous renal replacement therapy (CRRT) is approximately half compared to other group of patients receiving CRRT due to circuit clotting. However, liver failure patients can’t receive anticoagulants to prevent circuit clotting because of high risk for developed toxicity and bleeding. Modified membrane (oXiris®) is coated with anti-clotting material and has ability to remove cytokine in blood. This study is a pilot, single-center, prospective, randomized, crossover, open-label, clinical controlled trial which aim to assess the efficacy of modified membrane (oXiris®) compared to standard membrane and we hypothesized that modified membrane (oXiris®) has ability to prolong CRRT circuit life compared to standard membrane dialyser and decrease the blood level of cytokines.

This study will investigate the effects of cheese consumption on metabolic and gut health in healthy human subjects. Individuals participating in this study will be required to follow their usual diet (habitual diet) with minor adjustments regarding the consumption of cheese and dairy fermented products. Investigating the effects of cheese in the habitual diet under free living conditions will generate clinically relevant results and knowledge. The primary aim of this project is to characterise the response of the saliva, urine and stool microbiome and metabolome to habitual diets that differ in their type of production (quality)

This is a randomised controlled trial comparing negative pressure wound therapy (Prevena) with standard dressings for emergency laparotomy. The objective of the trial is to determine whether a negative pressure dressing reduces rates of surgical site infection and wound-related morbidity. This is a single-site study which aims to recruit 200 participants.

Diagnostic lung ultrasound will be used to diagnose acute lobar atelectasis in a mechanically ventilated population in intensive care. Lung ultrasound scans will also allow the research physiotherapist to assign aeration scores pre and post delivery of chest physiotherapy treatment. We hypothesise that lung ultrasound will be able to detect changes in lung aeration associated with a single chest physiotherapy treatment. This single centre prospective cohort trial of 43 mechanically ventilated patients will be conducted in intensive care at Royal North Shore Hospital.

Instability of the knee cap is a common problem and has a high recurrence rate, even with appropriate physiotherapy. When it has recurred, surgery becomes the necessary treatment. The surgical technique most commonly used involves the use of one of the patient's hamstrings to make a new ligament, the medial patello-femoral ligament. This technique uses one of the patient's own hamstrings and there is increased pain and an increased risk of complications associated with taking the hamstring graft. An artificial ligament, referred to as the ligament augmentation reconstruction system (LARS), is an alternative ligament that has been used for this operation, instead of the hamstring graft. This has the potential benefit of less pain, and a lower risk of complications. However there is no research to compare the outcomes of the two techniques used to reconstruct the ligament. The goal of the study was to compare the patient outcomes in patients undergoing the operation with the use of a hamstring graft versus the use of the LARS graft. Patients who are appropriate candidates and who agree to take part in the study, are randomly allocated to group 1 who have a hamstring graft, or group 2 who have a LARS ligament. Both groups will follow the same rehabilitation protocol to be supervised by a physiotherapist. Patients are allowed to weight bear as tolerable with a brace on, and the range of motion permitted in the brace is gradually increased over a period of 8 weeks. After this the patient can wean from the use of the brace. Patients can expect to make a complete recovery within 4 months of the surgery. The outcomes of interest are a questionnaire referred to as the Kajula score and Tegner activity score. These are completed before surgery and again at 1, 2, and 5 years post surgery. The results will be compared using statistical analysis.

The purpose of this study is to quantitatively compare early outcomes following duct to duct anastomosis during whole liver transplantation with or without a biliary stent. Randomised comparative data showing non-inferiority in the stent-free group could result in fewer post-operative biliary/endoscopic interventions, and change our current, non-standardised practice. Biliary stent placement during duct to duct anastomosis in whole liver transplantation confers no benefit with respect to biliary anastomotic complications when compared to a stent-free anastomosis but does result in a greater number of post-operative interventions to remove retained stents.

The primary objective of the study is to determine the amount of bupivacaine in the blood for adult subjects undergoing a total knee arthroplasty.

The aim of this study is to determine whether the thickness of lubricating eye drops for the front surface of the eye influences orthokeratology (OK) contact lens treatment outcomes. The primary outcomes to be measured are anterior eye health and comfort; the secondary outcomes of vision (eye prescription and how well an OK wearer sees) will also be explored with non-contact instruments. The participant, who is an existing OK lenses wearer, will be required to use their own lenses along with two lubricating eye drops that will be given to them by the researchers. These drops will be used once before inserting their lenses at night and once again before removing them. The participants will be required to visit the research clinic and researchers (UNSW Optometry Clinic, Kensington, NSW, Australia 2052) once a week for a total of 4 visits throughout the study. After the 2nd visit, the participants will undergo a wash-out period where they will be instructed to not use the provided lubricating eye drops. In this period, the participants have the opportunity to schedule their 3rd and 4th visit to their earliest convenience. Therefore, the participants can finish the study as quick as 1 month after applying.

The purpose of the study is to determine whether there is increased post-operative throat pain associated with Moffett's solution nasal preparation when compared with Co-phenylcaine. We hypothesize that there will be an increased in post-operative throat pain in the Moffett's solution group.

This is an implementation study, aiming to design and implement a clinical outcomes orthopaedic registry for patients presenting to a single centre practice with upper limb pathologies. The purpose of this registry is to report patient outcomes after treatment through a prospective, consecutive observational cohort study design. This clinical registry will collate and store patient outcomes collected routinely as part of the standard clinical pathway for upper limb pathology treatments. Outcomes will include objective joint function, patient reported outcomes (pain, satisfaction, quality of life), radiological findings and rates of revision surgery or complications. Recruitment will include all patients presenting with upper limb pathology to the principal or associate investigators at a single clinical practice (Geelong Orthopaedics). Patients will undergo standard of care consultation for diagnosis and treatment, including the collection of demographic data, patient medical history, radiological findings, pathology, and functional analysis. Patient evaluation will be completed routinely as part of the standard clinical pathway performed by the principal and associate investigators via the consulting rooms at Geelong Orthopaedics or hospital clinics. Patients will in addition be requested to complete a set of questionnaires (EQ-5D, Oxford shoulder scores (Pain and Instability scores), Quick DASH (upper limb function score), American Shoulder and Elbow Society (ASES) Score, Western Ontario Rotator Cuff (WORC) Score) and return to activity questions to enable evaluation of patient reported outcomes and complete physical assessments as part of the post- treatment follow up. The clinical outcomes of individual patients will be monitored for up to 5 years.