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The proposed project will evaluate the feasibility, acceptability and preliminary effectiveness of a telephone delivered intervention that targets problematic alcohol consumption in young people living with severe mental ill-health (SMI). Analysis will focus on issues associated with recruitment, ongoing engagement of participants, and satisfaction with the intervention. We will also examine changes in alcohol consumption and mental health symptomatology at follow-up. The randomised pilot trial compares the effects of two interventions: Quik Fix (2 session brief intervention) vs a 10 session Transdiagnostic CBT (TrCBT) intervention. Additional goals include • increasing the identification of young Australians experiencing comorbid SMI and hazardous alcohol use; • providing greater access to evidence-based treatments;

Right hepatectomy involves removal of a significant amount of liver parenchymal tissue and a lot of planning is required to ensure avoiding the inherent risks of major haemorrhage and severe hypotension. Over the last two decades, there have been the development of Enhanced Recovery After Surgery (ERAS) programmes particular for liver resections, aimed at reducing overall morbidity and length of hospital stay. . The traditional approach at Austin health focuses on “restrictive” fluid therapy, guided by “low central venous pressure anaesthesia” during liver resections. A second approach has been developed, which uses a surgery-specific cardiac output-guided algorithm for patients undergoing complex liver resection. This algorithm has been modified from another algorithm that has been used for pancreatic surgery. The aim of the study is to evaluate the two fluid intervention strategies and their differences in the use of intraoperative fluid, vasoactive medications, post-operative complications and hospital length of stay. This is a retrospective observational study that looked at patients undergoing major right hepatectomy with usual care or “traditional” restrictive fluid therapy & low CVP anaesthesia, compared to those who were managed with the surgery-specific cardiac output algorithm. It is hypothesised that the surgery-specific cardiac output-guided algorithm improves length of hospital stay and reduces morbidity and post-operative complications in major right hepatectomy.

The aim of this study is to define the dose of early rehabilitation intervention that provides the most benefit for people with ischaemic stroke of mild and moderate severity. 4 separate rehabilitation intervention regimens (different number, length and intensity of training sessions) will be implemented by physiotherapists and nurses in stroke units immediately post stroke. Participants will be followed up at 3 and 6 months post stroke. 2,700 patients with mild to moderate stroke will be recruited in Australia, New Zealand, Singapore, Malaysia, India and the UK. We hypothesise that the optimal dose intervention regimen will result in an improved outcome at 3 months post stroke, with less complications at 14 days and better quality of life at 6 months post stroke.

The purpose of this study is to investigate the safety of low-dose lenalidomide treatment after allogeneic stem cell transplantation for patients with acute myeloid leukaemia or myelodysplastic syndromes at high risk of relapse. Who is it for? You may be eligible to join this study if you are aged 18 years or above, and have been diagnosed with either high risk acute myeloid leukaemia (AML), OR high risk myelodysplastic syndrome (MDS). Study details All participants in this study will undergo treatment with the drug, lenalidomide, which will commence between day 40-45 after allogeneic stem cell transplant. Lenalidomide is an oral tablet, which will be taken for up to 48 weeks. The dose of lenalidomide in the study will commence at 2.5mg once per week, with subsequent groups increasing to 2.5mg twice per week, 5mg twice per week, 5mg every second day, 10mg every second day. Each participant will be assigned to receive one dose level for the entire study. The safety of lenalidomide treatment will be assessed by the incidence of side effects 120 days after starting the first dose of lenalidomide. This study will determine the safest dose of lenalidomide after allogeneic transplantation for patients at high risk of relapse.

The most commonly employed paeidtric procedural analgosedatives (PAS) over the past few decades have been both nitrous oxide (N2O) and ketamine. This is a prospective randomised comparison trial comparing inhaled N2O plus INF to IV ketamine for paediatric patients requiring PAS for fracture reduction. We hypothesis that N2O plus INF is equivalent to ketamine regarding overall procedural analgosedative efficacy for the patient in addition to being more cost-effective given the quicker offset of action and consequent shorter length of stay plus the requirement for fewer and less specialised medical personnel.

The purpose of this study is to help us to learn know more about Flinders University students food and eating habits, access to food, and nutrition knowledge and literacy. These findings will help to inform, tailor and target activities of the Nutrition Promotion for Flinders Student Health and Wellbeing Project to the nutrition needs of students studying at Flinders University.

The purpose of the study is to investigate whether a virtual reality exposure therapy program, delivered using 360 degree videos, can reduce public speaking anxiety compared to a neutral 360 video control. We expect that the 360 video program will lead to decreased public speaking anxiety at 2 weeks post-intervention compared to the control.

Unaccustomed muscular exercise can result in delayed onset muscle soreness (DOMS). DOMS is commonly associated with changes in the type or amount of exercise being performed and is a normal response to an appropriate exercise training program. The soreness results from the muscle remodelling itself to deal with the new exercise demand. Symptoms of DOMS can range from muscle tenderness to severe debilitating soreness. This soreness leads to the perception of functional impairment, along with reductions in muscular strength and power. The intensity of these symptoms and the related discomfort increases within the first 24 hours following exercise, and peaks between 24 to 72 hours post exercise. Assessment of DOMS currently consists of invasive measures or subjective scales. An accurate, non-invasive and objective measure by which DOMS could be observed and quantified would provide great insight into recovery interventions, load monitoring, injury prevention and ensuring optimum athletic performance. Muscle contraction and muscle remodelling results in the generation of heat. Measuring muscle temperature is an invasive and impractical procedure. However the heat that is generated within the muscle is subsequently transferred to the skin surface to be dissipated into the air, enabling skin temperature assessment to be utilised as a potential surrogate marker of muscle temperature. Therefore, the aims of this investigation are to utilise two novel thermal imaging cameras (HeatWave and HeatStand) to 1) attempt to quantify muscle activity through skin surface temperature fluctuations; and 2) compare and contrast with the current tools for DOMS assessment.

Obstructive sleep apnea (OSA) is a common sleep disorder, and is linked with excessive and inappropriate sleepiness, impaired cognition, increased risk of motor vehicle crashes and workplace accidents. However, not all patients with OSA display daytime impairments and it is still not completely known how OSA affects the brain. A key to understanding this is by investigating the brain activity of patients with OSA, and how this may change following CPAP therapy, the gold standard clinical treatment for OSA. This can be easily done through non-invasive EEG recordings from electrodes placed on the scalp that are a routine part of sleep studies when screening for OSA. This study uses advanced high-density electroencephalography (hdEEG) to investigate whether areas of ‘tired’ neurons that fall asleep in the awake brain underlie daytime impairments in OSA. The purpose of this study is to examine the effect of regular CPAP use versus short-term CPAP withdrawal on daytime function and brain wave activity recorded in patients diagnosed with moderate to severe OSA. We will investigate brain activity during sleep and during awake daytime performance testing.

Currently there is no standard anesthetic agent recommended for robotic pelvic and abdominal surgery. Anaesthetic agents have variable effects on the cerebral vasculature and it has been hypothesized that some may be more suitable for robotic pelvic and abdominal surgery than others. For instance, Sevoflurane, a volatile anesthetic agent, increases cerebral vasodilation and hence decreases vascular resistance. This may impair cerebral autoregulation. Propofol, an intravenous agent, has not been shown to affect cerebral vasodilation. A feature of robotic surgery is the requirement for carbon dioxide pneumoperitoneum in conjunction with steep head-down positioning. We hypothesise that the cerebrovasodilatory effects of carbon dioxide combined with the potential for oedema from head-down positioning could render the brain particularly susceptible to the vasodilatory effects of volatile anaesthetics, including sevoflurane. Cerebral oedema is a recognised, although rare, complication of robotic prostate surgery. These are long procedures with the patient in a steep head-down position. Previous studies have shown alterations in cerebral blood flow towards the end of surgery. Therefore, the primary outcome of this study will be the last cerebral autoregulation recording at the end of surgery, with a comparison between patients with their anaesthesia maintained with propofol or sevoflurane