ANZCTR search results

This is a pilot study to evaluate the safety of a personalized tumour neo-antigen peptide vaccine strategy in non-small cell lung cancer (NSCLC). Who is it for? You may be eligible for this study if you are an adult who has been diagnosed with early stage non-small cell lung cancer and is planned for surgery. Study details All participants in this study will be required to attend the Sir Charles Gardner Hospital to receive a vaccine fortnightly for the first 4 doses (8 weeks), and then 4 weekly for another 4 doses (16 weeks). You will monitored with blood tests before each dose. This research project hopes to discover a new and effective treatment for patients with non-small cell lung cancer.

The purpose of this study is to determine if the use of an antibiotic (Ceftriaxone) post-radical prostatectomy will help prevent urinary tract infections in patients with a indwelling catheter inserted at time of trial of void. You may be eligible for this study if you have prostate cancer and are undergoing a robot assisted laparoscopic radical prostatectomy at the Wesley Hospital. Study details Participants will be randomly allocated to one of two groups, the intervention group (standard care) or the placebo group. The procedure in the intervention group will involve: a) Injecting 1g of antibiotic (Ceftriaxone) via an injection in the arm at time of catheter removal (one week post-surgery). b) Collection of urine samples and blood The placebo group will receive: a) Injecting 10ml of saline via an injection in the arm at time of catheter removal (one week post-surgery). b) Collection of urine samples and blood It is hoped that this study will determine if antibiotics reduce the incidence of symptomatic urinary tract infections after catheter removal as currently they are being given to every person, which may lead to increased antibiotic resistance if they are not actually required.

Funduscopy is not widely performed, to the detriment of patients whose vision-threatening and life-threatening disorders may not be detected. The decline of fundoscopy has been ascribed to technical challenges of the examination, and difficulties interpreting the findings. Non-mydriatic fundus photography (NMFP) has been demonstrated to improve detection of fundus abnormalities in patients presenting to the emergency department (ED). We aim to determine the prevalence of fundus abnormalities amongst selected patients presenting to Australian EDs, and the clinical impact of NMFP for these patients.

This study aims to test the feasibility of a six week intervention on a class of stage 3 students. The intervention will involve two one-hour sessions per week. Each session will include a combination of martial arts inspired activities, mathematics games, and well-being discussions. The content aims to improve childen's cognition, on-task behaviour, academic performance, social and emotional well-being, and physical fitness. Based on previous studies of (somewhat) similar natures, The research team hypothesises that the intervention will be successful in making positive impacts on these outcomes.

Multiple sclerosis (MS) is rare but increasing in incidence. Our Australian work shows that five years of a first demyelinating event, 41% of people will have clinical fatigue with depression frequently comorbid. Single nutrient therapy with antioxidants directed to mitochondrial support have shown some benefit for fatigue and depression, oxidant damage prevention and improved clinical course in multiple sclerosis. This double-blind randomised controlled trial will run a 20-week therapy of combined mitochondrial support agents against placebo. The therapy will include coenzyme Q10, alpha-lipoic acid, N acetyl cysteine, biotin and other agents. Trial participants will be people with relapsing remitting multiple sclerosis with fatigue. The trial will assess the extent that these therapies reduce fatigue, depression, and metabolomic abnormalities in MS.

This is a phase 3 randomised, double blind, placebo controlled efficacy study in 255 participants exhibiting the common cold. Subjects will dose 20 times over 5-6 days, max 4 doses a day. Subjects will also complete the WURSS 21 questionnaire from day 1 to Day 6, and complete item 1 from the questionnaire from day 7 to 14.

Aims: to determine the clinical and cost-effectiveness of a prophylactic silicone foam border dressing in preventing sacral (tailbone) hospital-acquired pressure injuries (HAPI) in at-risk medical-surgical patients; describe the characteristics and clinical care received by patients who develop a sacral HAPI up to 14 days, or until hospital discharge or death after sacral HAPI occurrence; and understand patients' and staff perspectives on the use of prophylactic dressing. Hypotheses: Primary hypothesis: The cumulative incidence of patients who develop sacral HAPI up to 14 days of admission will be less in patients who are randomly allocated to the intervention group (i.e. routine care plus the trial dressing) compared to patients allocated to the control group (i.e. routine care only). Secondary hypotheses: The intervention group will have better outcomes compared to the control, including 1) time to onset of sacral HAPI; 2) incidence of severity (stage) of sacral HAPI; 3) cost-effectiveness; and 4) process evaluation.

South Asian Mother's Becoming Active (SAMBA) is a culturally-sensitive and collaboratively-designed intervention to support South Asian women to become more physically active. The intervention was developed through community-based participatory research, that included focus group discussions and individual interviews with women from the South Asian community. The aim of the intervention is to implement and evaluate a pilot, single-blinded randomized controlled trial with an experimental group of 40 South Asian women, and a delayed matched-control group, at two community settings in metropolitan Perth. Women from the Indian, Pakistani, Bangladeshi, Sri Lankan, Nepali and Bhutanese communities will be recruited to take part. We will assess changes in levels of objectively-measured physical activity, sedentary behaviour, and BMI; in addition to self-reported physical activity-related motivation, and psychological well being.

Our research team is part of a group that has been awarded a grant to establish the Prevention Hub Mental Health Research Program. The Prevention Hub will focus on implementing and evaluating preventative strategies for anxiety and depression in workplace, school, and healthcare settings to achieve the greatest possible impact and reach. This application is intended to cover pilot of a smartphone-based intervention (Anchored) aimed at promoting mental health and wellbeing within Australian workers. Participants will complete assessments at baseline and 5 weeks post-baseline. The primary aim of the pilot is to test the impact of the Anchored app on reducing depressive symptoms among employed Australians. The pilot also aims to: - test the impact of the Anchored app on anxiety, wellbeing, resilience, and work productivity. - explore participant engagement with the activities in the app. - explore level of satisfaction with the app and confidence in managing stressors.

V-A ECMO is a specialised cardiorespiratory support for patients with severe heart dysfunction. ECMO supports the circulation via a pump, and gas exchange (oxygen and carbon dioxide) occurs via an external membrane. ECMO patients are vulnerable to both rapid weight loss as well as complications related to overfeeding. Therefore the provision of the correct amount of nutrition is an essential element of care. However, we are currently uncertain of how to accurately determine the energy they require, as gas exchange across the external membrane means current measures are inaccurate. The aim of this study is to explore the feasibility of measuring carbon dioxide production and oxygen consumption across the ECMO membrane as well as the lung in 30 mechanically ventilated critically ill patients receiving V-A ECMO at two points during Intensive Care Unit admission. Exact energy expenditure has not previously been established in V-A ECMO. The completion of this study will work towards improving the accuracy of nutrition delivery in this patient group.