ANZCTR search results

The human microbiome, the population of microbes occupying various body sites, is already known to have a major impact on human health with the changes in the gut microbiota during pregnancy known to be particularly fascinating. However, there is limited research on the microbiome and its relationship to maternal and newborn health and disease. Therefore, the aim of this study is to recruit a large perinatal and newborn cohort, of approximately 2000 participants, in order to comprehensively investigate the microbiome during this critical period of a mother and child’s life. Women will be recruited prior to conceiving a child, to fully examine the microbiota, and observe the changes from pre-conception, conception, and pregnancy through to birth and into the first year of thechild's life. There is a projected time commitment for participants of 22-33months, depending on time of conception.

The purpose of this study is to assess the utilisation of an Implantable Loop Recorder to aid in the management of symptom control of Paroxysmal Atrial Fibrillation.We hypothesise that an Implantable Loop Recorder can be effectively used in a nurse led cardiologist supported AF clinic to guide and co-ordinate the management of patients with a high burden of symptoms related to their Atrial Fibrillation.

Peripheral IV cannulation is one of the most frequently performed invasive procedures in the hospital setting, and an essential means of providing hydration, nutrition and medication to admitted patients, including neonates . The insertion, monitoring and maintenance of these devices, to prevent complications, are an important component of neonatal nursing care. The most common complications of PIVC use include extravasation, infiltration, occlusion, infection, and phlebitis - accounting for the failure and removal of 95% of PIVCs. Although these complications are usually minor, some neonates may experience serious, or even life-threatening sequelae, with the potential for long-term functional difficulties, significant scarring, and psychological effects. The current failure rate of PIVC in the neonatal population is estimated at around 60%, however the optimal securement method of a PIVC has not been well established. We have designed a randomised controlled trial to assess whether using a specifically designed splint and protection device may be useful to prevent PIVC failure as compared to standard splinting and securement in the neonatal population. Our hypothesis is that the specifically designed splint and protection device will significantly decrease PIVC failure as compared to standard splinting and securement in the neonatal population.

This study is a pilot study looking at the efficacy and feasibility of pre-operative very low energy diet in patients with BMI greater than 30, prior to laparoscopic colorectal study. Participants will be prescribed the Optifast Intensive Program on a daily basis after enrolment in the study and will take the Optifast meal replacement until the day of surgery.

The aim of Supernova 2 is to investigate the effects of 3 weeks adaptation to the LCHF diet and 2 weeks of deadaptation (reintroduction of high CHO diet), on substrate use and subsequent race performance as well as several health related outcomes such as inflammation, iron health, bone health and gut function in world class female and male race walkers.

This study will be conducted to determine if smart phone-based (Kardiamobile) single lead electrographic (sECG) recording systems have a superior yield for the diagnosis of hearth rhythm disorders compared to repeating traditional ambulatory monitoring (Holter) in patients with undiagnosed palpitations. Participants who meet the inclusion criteria will be randomised 1:1 to either the intervention group (Kardiamobile sECG) or control group (standard care with multiple ambulatory Holter monitors). This clinical trial will run over 2 years with a planned recruitment of 80 patients (40 in each group). A follow up period of 6 months will aid to determine which approach is superior for the diagnosis of symptom related-heart rhythm abnormalities. Control arm Patients randomised to the control arm will be managed as per standard care. Standard care will comprise of sequential ambulatory multi-day Holter monitors (5 days), up to 3 in number, over a period of 6 months, separated by at least 4 weeks. Intervention arm Patients randomised to the intervention arm will be offered the Alivecor KARDIAMOBILE (Smart phone-based sECG). The smartphone/smartwatch platform allows a single lead ECG recording of up to 5 minutes. Study outcomes The primary outcome of this study will be the proportion of patients in whom a definite diagnosis of palpitations is made with an underlying rhythm that correlated with symptoms (symptom-rhythm correlation) or a serious rhythm abnormality is recorded over the 6 month follow up period.

This is a safety study of quadrivalent inactivated influenza virus vaccine, Afluria Quad and Afluria Quad Junior, conducted over three Southern Hemisphere vaccination seasons to provide ongoing characterisation of the reactogenicity profile of Afluria Quad in the clinical and public health environment.

Exendin PET scans are special nuclear medicine imaging scans. These scans can detect cancers whose cells have a chemical, called the GLP1 receptor, on their surfaces. However, we are unaware of any reports of the use of Exendin PET scanning in prostate cancer. The purpose of this study is to determine if prostate cancer can be detected by Exendin PET scans. Who is it for? You may only be eligible for this study if you have metastatic castrate-resistant prostate cancer and have already been identified as potentially suitable for the study by our research team. Study details The study will assess whether PET scans using the chemical called Exendin can detect metastatic prostate cancer. Participants will have had a PET scan using the chemical PSMA (which is the usual type of PET scan used to detect prostate cancer) within the preceding 2 weeks. They will then have a single Exendin PET/CT scan at a major hospital. The procedure will involve: a) Injecting the study chemical (called [68Ga]-DOTA-Exendin) into an arm vein. b) Finger prick glucose testing to confirm participant blood sugar levels. c) An Exendin PET scan 60 minutes after the chemical injection. We hope this will demonstrate that prostate cancers can be detected by Exendin PET scans. If we can demonstrate that, we will have confirmed that prostate cancers bear GLP1 receptor.

This study will examine the effects of biomechanical tape on pain and function in people with tennis elbow. Each participant will attend three sessions, where one of the following will be applied in a random order, 1) biomechanical tape, 2) control tape, and 3) no tape. Participants will have their pain intensity, grip strength, muscle activity, and wrist posture measured three times during each of the three sessions, 1) before the tape (or no tape), 2) immediately after the tape (or no tape), and 3) immediately after an exercise circuit wearing the tape (or no tape). The research hypotheses are that biomechanical tape will result in a reduction in pain, a reduction in wrist extensor muscle activity, an increase in pain-free grip strength in the affected arm, and an improvement in wrist posture, when compared to the control tape technique, or no tape.

Effect of eating at night time results in blood glucose levels up to 6 times higher than the same meal consumed in the morning. Dietary polyphenols favourably influence blood glucose, but studies are usually undertaken in the morning. We hypothesise that polyphenols from green tea incorporated into a meal may be effective at lowering blood glucose both in the morning and at night.