ANZCTR search results

Poor vision is a risk factor for falls among older people but it is not known whether improving vision prevents falls. In this study, subjects in the intervention group have a comprehensive eye examination and receive appropriate treatment. It is hoped that this will result in fewer falls over the next 12 months than in an untreated control group.

To assess the efficacy and safety of delayed onset Certican (Everolimus) compared to Myfortic (enteric coated Mycophenolate Sodium: MPS), both arms in combination with Cyclosporin A (CsA)(monitored by C2 levels) and corticosteroids for the prevention of chronic rejection (Bronchiolitis Obliterans Syndrome: BOS) in the first 3 years post transplant when given as de novo maintenance therapy for the management of lung allograft recipients after bronchial anastomotic healing has been confirmed at bronchoscopy.

This is a randomised, open label, multicentre clinical trial of two different doses of imatinib to test whether there is any difference in disease outcome between the doses in patients with unresectable or metastatic malignant gastrointestinal stromal tumours (GIST). Recruitment opened in 2001, closed in 2002 with 946 patients worldwide and 116 at Australian, NZ and Singapore sites. Long term Follow UP closed October 2016.

This randomised controlled trial compares the new diagnostic strategy for Invasive Aspergillosis (IA) to the current standard diagnostic strategy. The new diagnostic strategy uses Aspergillus ELISA and an Aspergillus nested PCR assay to diagnose/exclude IA and direct further management including timing of HRCT scan of thorax. Eligible patients are aged 18-80 and have received an allogeneic haematopoietic stem cell transplant or are undergoing intensive combination chemotherapy for acute myeloid leukaemia or acute lymphoblastic leukaemia. The study aims to determine which strategy results in lower: rates of empiric antifungal therapy administration; drug–related toxicities; IA-related mortality rates and overall mortality rates.

Aims: To conduct a first-ever long-term (10-15 years) follow-up of individuals at risk of Alzheimer’s disease (AD) who participated in a 6-month physical activity intervention versus usual-care to asses the effects on cognition, mental and physical health, and quality of life. Hypothesis: We hypothesise that the group who undertook the physical activity intervention will have better mental and physical outcomes and a lower rates of Alzheimer’s disease and lower use of health services. Methods: Individuals recruited into the original trial were re-contacted and invited to take part in this follow-up. In Stage 1 of the Follow-up study invitations were posted with 69 re-interviewed and data collected. In Stage 2 we propose to access information from the WA Department of Health data linkage service for those not withdrawing from the original study and those opting out of the follow-up interview to obtain information from several linked health agency databases.

Comparison of bronchial mucus transport velocity in patients having either sevoflurane or desflurane based anaesthesia.

The study followed the health outcomes of 124 Independent Living Unit residents aged 75 years or over and living alone to see if health assessments and early basic interventions had an impact on their health and well being. If required, interventions included health information, specialist referrals, and home help. Residents were linked to a community nurse, who provided low intensity case management by phone every three months. Half of the participants participated in the early intervention experimental model, while the remainder received their usual community care. At the end of the 12 month study period, those involved in the experiment had a higher level of satisfaction with community care, but more time was needed to see if there were other detectable health outcomes. We found previously unidentified needs among 66% of the experimental group, and throughout the course of the study most of those needs were resolved. However, no other benefits from the program were detected after one year in terms of health perception, functional ability, psychosocial status, health resource utilisation and mortality. This was consistent with many other similar studies.